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Novel On-line PET Based Intra-Beam Range Verification and Delivery Optimization for Improved Particle Radiation Therapy

基于新型在线 PET 的束内范围验证和传输优化，以改进粒子放射治疗

基本信息

批准号：
10355422
负责人：
Weiguo Lu
金额：
$ 27.39万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-09 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10355422
关键词：
Algorithmic Software Algorithms Alpha Particles Belief Biological Brain Budgets Clinical Clinical Research Development Dose Ensure Future Goals Image Lead Malignant neoplasm of brain Measurement Measures Methods Monte Carlo Method Normal tissue morphology Online Systems Organ Outcome Outcomes Research Patient Care Patients Performance Photons Physiological Positioning Attribute Positron-Emission Tomography Problem Solving Process Radiation Radiation Dose Unit Radiation therapy Research Research Project Grants Resolution Retreatment Risk System Technology Testing Therapeutic Therapeutic Effect Time Treatment Efficacy Uncertainty base cancer therapy clinical application flexibility image guided imaging modality imaging system improved in vivo imaging innovation innovative technologies new technology novel novel strategies particle particle beam particle therapy physical property process optimization proton beam proton therapy prototype radiotracer success targeted treatment therapy outcome treatment planning treatment site tumor

项目摘要

PROJECT SUMMARY There are inherent physical uncertainties with particle therapy (i.e. beam range uncertainty) which have become major factors leading to large margins, thereby unnecessarily exposing additional dose to normal tissues, and forcing clinicians taking overly conservative treatment plans to restrict the dose to tumor or avoiding advantageous beam angles to ensure sparing of critical organs at risk. It is critically important to overcome this impediment in order to dramatically enhance particle therapy outcomes and achieve its full clinical benefits. The goal of this research project is to develop an innovative PET image-based on-line verification of proton therapy for brain cancer treatment instead of the current off-line method in order to directly measure the potential deviation of actual proton beam range from that predicted by the treatment plan before the start of treatment. In this project, we challenge the conventional belief and propose a unique approach of using part of the therapy beams for imaging, thus overcoming the long-standing technical obstacle for achieving the on-line PET imaging method. We will pursue three specific aims to achieve the goal of this project: 1) Develop and evaluate a brain PET capable for desired on-line imaging; 2) Develop and evaluate algorithms and software that will select probing beams for range measurement and enable range-shift compensated beam delivery; 3) Establish and improve the on-line PET based range measurement and adaptive particle therapy. The success of this project will fill a critical technical gap and make the on-line PET based range measurement and adaptive particle therapy clinically practical for the first time. It could shift clinical study with a new image-based particle therapy paradigm, which will significantly improve the particle beam targeting, enable new and better treatment plan, and improve the therapy efficacy and patient care. The outcome of this project will also pave the way to develop similar technology for whole-body on-line PET imaging and adaptive particle therapy applications.

项目摘要粒子治疗存在固有的物理不确定性（即射束范围不确定性），成为导致较大裕度的主要因素，从而不必要地将额外剂量暴露于正常组织，并迫使临床医生采取过于保守的治疗计划，以限制剂量的肿瘤或避免有利的射束角度以确保免于危及关键器官。至关重要的是，克服这一障碍，以显着提高粒子治疗的结果，并实现其充分临床获益。本研究项目的目标是开发一种创新的PET图像为基础的在线验证质子疗法治疗脑癌，而不是目前的离线方法，直接测量实际质子束范围与治疗计划预测范围的潜在偏差在治疗开始之前。在这个项目中，我们挑战传统的信念，并提出了一个独特的使用部分治疗光束进行成像的方法，从而克服了长期存在的技术障碍用于实现在线PET成像方法。我们将追求三个具体目标，以实现这一目标项目：1）开发和评估能够进行所需在线成像的脑PET; 2）开发和评估算法和软件将选择探测光束进行距离测量，并实现距离偏移 3）建立和改进基于PET的在线距离测量，自适应粒子疗法该项目的成功将填补一个关键的技术空白，使在线PET 基于距离测量和自适应粒子治疗的临床实践的第一次。它可能会转移一个新的基于图像的粒子治疗范例的临床研究，这将显着提高粒子波束靶向，使新的和更好的治疗计划，并提高治疗效果和病人护理。的该项目的成果也将为开发用于全身在线PET的类似技术铺平道路成像和自适应粒子治疗应用。