A Comprehensive 5K Plus Glycan Microarray
综合 5K Plus 聚糖微阵列
基本信息
- 批准号:10353411
- 负责人:
- 金额:$ 51.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffinityAvidityBindingBiologicalBiological MarkersBiotechnologyBusinessesCell surfaceCellsCharacteristicsCollectionComplexComputer softwareCustomData AnalysesData ScientistData SetDatabasesDevelopmentDiseaseEngineeringEnsureEnzymesEventFinancial costFosteringFundingGlycobiologyGlycopeptidesGrantImageImmune systemImmunotherapyIndustrializationIntuitionLectinLibrariesLiquid substanceMannoseMarketingMediatingMethodsMindMucinsPharmacologic SubstancePhasePhysiologicalPolysaccharidesPositioning AttributeProcessProductionProteinsProviderPublic HealthQuality ControlResearchResearch InstituteResearch PersonnelResourcesRouteScientistSignal TransductionSmall Business Innovation Research GrantSourceSpecific qualifier valueSpecificitySpottingsStructureSulfateSurfaceSystems IntegrationTherapeuticTimeUniversitiesVaccinesVendoranalysis pipelineautomated analysisbasecommercial applicationcomparativecostexperienceinsightmacromoleculemanufacturing scale-upmolecular recognitionnew technologyprogramsreceptorresearch and developmentscale upsugar nucleotidesurface coatingtool
项目摘要
Project Summary / Abstract
The Glycan Array has proven a valuable tool in the study of glycans. Comparatively the Glycan Array gives the
greatest view of glycan binding specificity for the lowest cost in terms of analytical turn-around time and financial
cost. The Glycan Array is far from well optimized in our mind. There are three key limitations to an array-based
approach with high throughput glycan-protein interaction profiling: 1) glycan arrays suffer from a systematic lack
of sensitivity, 2) current array providers lack comprehensive glycan libraries with scalable synthetic routes, and
3) physiological glycan binding is intricate and complex and requires a lengthy analysis process. In Phase I we
sought out to find solutions for each of these limitations. First, we developed a first of its kind Glycan Array that
can analyze glycan binding avidity not just affinity. Second, we partnered with an elite group of chemists to
produce a glycan library containing ~900 glycan structures, which is larger than that of the CFG and one of the
largest ever. Third, we partnered with a group of data scientists and bioinformaticians to create a robust software
package that automates the entire array data analysis process. Over the last three years we have formed
valuable relationships with researchers and clinicians in research institutes, pharmaceutical companies and
public health sectors. Z Biotech is perfectly positioned to facilitate the supply for increasing demand for
biomedically relevant glycan arrays.
In each of these endeavors Z Biotech sincerely thanks to the support of this SBIR grant. Now in Phase II we are
seeking funds to continue to find solutions for these key limitations in Glycan Array. First, we will continue to
invest heavily in R&D to ensure that our arrays offer superior insights compared to our competitors. We will also
use funds from Phase II to scale up production to accommodate increasing demand. Second, we will team with
Dr. Lei Li’s group at Georgia State University. Dr. Li is an outstanding glyco-scientist with experience in
production of complex glycans, sugar nucleotides and glycan-related enzymes. With his effort we will maintain
our current glycan library and add ~2,000 new glycan structures in Phase II. Third, we will complete Z Biotech’s
custom software package. In Phase II we will bring this first of its kind glycan array data analysis package or
solution to market.
项目总结/摘要
聚糖阵列已被证明是研究聚糖的一个有价值的工具。相比之下,聚糖阵列给出了
在分析周转时间和财务方面,以最低的成本获得聚糖结合特异性的最佳视角
成本聚糖阵列在我们的脑海中远远没有得到很好的优化。基于阵列的有三个关键限制
具有高通量聚糖-蛋白质相互作用谱分析的方法:1)聚糖阵列遭受系统性缺乏
2)目前的阵列提供商缺乏具有可扩展合成路线的全面聚糖文库,以及
3)生理性聚糖结合是错综复杂的,并且需要冗长的分析过程。在第一阶段,我们
试图找到解决这些限制的方法。首先,我们开发了第一种聚糖阵列,
可以分析聚糖结合亲合力而不仅仅是亲和力。其次,我们与一群精英化学家合作,
产生含有约900个聚糖结构的聚糖文库,其大于CFG的聚糖文库,并且其中之一
最大的。第三,我们与一群数据科学家和生物信息学家合作,创建了一个强大的软件,
自动化整个阵列数据分析过程的软件包。在过去的三年里,我们成立了
与研究机构、制药公司的研究人员和临床医生建立了宝贵的关系,
公共卫生部门。Z Biotech完全有能力促进供应,以满足日益增长的需求,
生物医学相关的聚糖阵列。
在这些努力中,Z Biotech真诚地感谢SBIR资助的支持。在第二阶段,
寻求资金,继续寻找解决聚糖阵列中这些关键限制的方法。一是继续
在研发方面投入巨资,以确保我们的阵列提供比竞争对手更上级的洞察力。我们还将
利用第二阶段的资金扩大生产,以满足日益增长的需求。第二,我们将与
博士格鲁吉亚州立大学的Lei Li小组。李博士是一位杰出的糖科学家,
生产复合聚糖、糖核苷酸和聚糖相关酶。在他的努力下,
我们目前的聚糖库,并在第二阶段增加约2,000个新的聚糖结构。第三,我们将完成Z Biotech的
定制软件包。在第二阶段,我们将带来第一个聚糖阵列数据分析包,
解决市场。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lei Li其他文献
Lei Li的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lei Li', 18)}}的其他基金
Expedite Enzymatic Assembly of Glycans via DNA (de)Hybridization-Enabled Catch-and-Release
通过 DNA(去)杂交捕获和释放加速聚糖的酶促组装
- 批准号:
10648697 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Center for the Investigation of Factor VIII Inhibitors and Glycosylation
因子 VIII 抑制剂和糖基化研究中心
- 批准号:
10406318 - 财政年份:2018
- 资助金额:
$ 51.92万 - 项目类别:
Center for the Investigation of Factor VIII Inhibitors and Glycosylation
因子 VIII 抑制剂和糖基化研究中心
- 批准号:
10227911 - 财政年份:2018
- 资助金额:
$ 51.92万 - 项目类别:
Facile Synthesis of O-Glycans and O-Glycopeptides
O-聚糖和 O-糖肽的简便合成
- 批准号:
8985647 - 财政年份:2015
- 资助金额:
$ 51.92万 - 项目类别:
Battling AIDS via Mechanistic Understanding of the tRNA Phe modification enzyme T
通过对 tRNA Phe 修饰酶 T 的机制理解来对抗艾滋病
- 批准号:
8229462 - 财政年份:2012
- 资助金额:
$ 51.92万 - 项目类别:
相似海外基金
Construction of affinity sensors using high-speed oscillation of nanomaterials
利用纳米材料高速振荡构建亲和传感器
- 批准号:
23H01982 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Affinity evaluation for development of polymer nanocomposites with high thermal conductivity and interfacial molecular design
高导热率聚合物纳米复合材料开发和界面分子设计的亲和力评估
- 批准号:
23KJ0116 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants
开发高亲和力和选择性配体作为多巴胺 D4 受体 (D4R) 亚型变体的药理学工具
- 批准号:
10682794 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Platform for the High Throughput Generation and Validation of Affinity Reagents
用于高通量生成和亲和试剂验证的平台
- 批准号:
10598276 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Collaborative Research: DESIGN: Co-creation of affinity groups to facilitate diverse & inclusive ornithological societies
合作研究:设计:共同创建亲和团体以促进多元化
- 批准号:
2233343 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Standard Grant
Collaborative Research: DESIGN: Co-creation of affinity groups to facilitate diverse & inclusive ornithological societies
合作研究:设计:共同创建亲和团体以促进多元化
- 批准号:
2233342 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Standard Grant
Molecular mechanisms underlying high-affinity and isotype switched antibody responses
高亲和力和同种型转换抗体反应的分子机制
- 批准号:
479363 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Operating Grants
Deconstructed T cell antigen recognition: Separation of affinity from bond lifetime
解构 T 细胞抗原识别:亲和力与键寿命的分离
- 批准号:
10681989 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
CAREER: Engineered Affinity-Based Biomaterials for Harnessing the Stem Cell Secretome
职业:基于亲和力的工程生物材料用于利用干细胞分泌组
- 批准号:
2237240 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Continuing Grant
ADVANCE Partnership: Leveraging Intersectionality and Engineering Affinity groups in Industrial Engineering and Operations Research (LINEAGE)
ADVANCE 合作伙伴关系:利用工业工程和运筹学 (LINEAGE) 领域的交叉性和工程亲和力团体
- 批准号:
2305592 - 财政年份:2023
- 资助金额:
$ 51.92万 - 项目类别:
Continuing Grant