Reward Learning in Late-Life Suicidal Behavior
晚年自杀行为的奖励学习
基本信息
- 批准号:10355456
- 负责人:
- 金额:$ 68.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectiveAttentionBehaviorBehavioralBrain InjuriesBrain imagingClinicalCognitionCognitiveComputer ModelsComputing MethodologiesDataDecision MakingDepressed moodDisease susceptibilityDorsalElderlyEmotionalEnsureEntropyFailureFeeling suicidalFunctional Magnetic Resonance ImagingFundingHeterogeneityImpaired cognitionImpairmentIndividualInformation ManagementInterventionLearningLifeMaintenanceMental DepressionNational Institute of Mental HealthNeurosciencesParietalPersonalityPersonsProcessProtocols documentationPsychological reinforcementPsychopathologyRecording of previous eventsReproducibilityResearchResearch Domain CriteriaResearch PersonnelResourcesRewardsRisk ManagementSamplingSignal TransductionStatistical MethodsStudy modelsSuicideSuicide attemptTestingTheoretical modelThinkingTimeUncertaintyVulnerable PopulationsWorkbasecomputer frameworkdesignexperimental studyforgettingimaging modalityimaging studyinformation modelinformation processingmathematical modelneural circuitneuroimagingneuromechanismnovelpressurerelating to nervous systemresponsesuicidalsuicidal behaviorsuicidal risksuicide attemptersuicide ratesuicide victimtheories
项目摘要
ABSTRACT
The US is facing rising suicide rates. Yet, we have only a limited understanding of why some people, but not
others, progress from contemplating to attempting suicide. In the past funding period, we have shown that
depressed older adults whose decision-making is impaired are more likely to progress from suicidal ideation to
action. Specifically, using decision experiments, computational modeling, and fMRI, we have found replicable
deficits in learning and choice processes paralleled by altered ventromedial and dorsolateral prefrontal abstract
learning signals. In this renewal application, we propose to extend these findings by examining how people at
risk for suicide make decisions under cognitive and emotional demands that are more representative of the
suicidal crisis. In our computational framework these demands include (i) a high information load and (ii)
constraints on information processing imposed by time pressure and impending threats. We have developed
and validated new experimental and computational methods for studying information-processing bottlenecks
during decision-making. Specifically, our reinforcement learning computational model applied to behavioral and
neuroimaging data, enables us to examine how people use their limited neurocomputational resources to make
good decisions under high information load. Our preliminary studies show that decision-making in this context
(i) relies on resource-rational strategies for managing information load, (ii) is subserved by dorsal attention and
cingulo-opercular networks, (iii) is likely disrupted in attempted suicide, (iv) a deficit paralleled by abnormal
dorsal attention network responses to information load. We thus propose to test the general hypothesis that
people at risk for suicide are prone to information-processing bottlenecks arising from alterations in these
cortical networks. We will perform decision experiments and cognitive computational models (Aim 1) in a
discovery sample and a non-overlapping replication sample (n = 200 each) to ensure that findings are robust to
the clinical and cognitive heterogeneity of suicidal behavior. Both samples will include individuals maximally
representative of suicide victims, namely older depressed suicide attempters, about half of whom survived
near-lethal attempts. Functional neuroimaging experiments manipulating information load will interrogate the
neurocomputational dynamics of the dorsal attention network and cingulo-opercular network during decision-
making in one sample (n = 200, Aim 2). A careful characterization of psychopathology, personality, cognition,
psychotropic exposure and brain damage from suicide attempts will allow us to control for key confounds. The
interdisciplinary team has expertise in mechanisms of suicidal behavior (Dombrovski), decision neuroscience
(Dombrovski, McGuire, Hallquist), imaging methods (Hallquist), and suicide risk management (Szanto,
Dombrovski). This work aligns with a key objective of the NIMH’s prioritized research agenda on suicide: “to
identify cognitive dysfunction/neural circuitry profiles … associated with suicide risk” and taps into the
reinforcement learning and limited capacity constructs of the RDoC framework.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alexandre Y. Dombrovski其他文献
Poster Number: EI 20 - The Personality of Older Attempters: A Key to Heterogeneity in Suicidal Behavior
- DOI:
10.1016/j.jagp.2018.01.111 - 发表时间:
2018-03-01 - 期刊:
- 影响因子:
- 作者:
Anna Szucs;Katalin Szanto;Alexandre Y. Dombrovski - 通讯作者:
Alexandre Y. Dombrovski
151. Salience and Default Mode Network Coupling Role in Expectancy-Mood Interactions in Depression
- DOI:
10.1016/j.biopsych.2024.02.386 - 发表时间:
2024-05-15 - 期刊:
- 影响因子:
- 作者:
Kevin Handoko;Alyssa Neppach;Helmet Karim;Alexandre Y. Dombrovski;Marta Pecina - 通讯作者:
Marta Pecina
99. Antagonism Facets Uniquely Affect Cooperation: Narcissism and Callousness are Differentially Associated With Tit-For-Tat Reciprocity
- DOI:
10.1016/j.biopsych.2023.02.339 - 发表时间:
2023-05-01 - 期刊:
- 影响因子:
- 作者:
Timothy A. Allen;Jacob W. Koudys;Vanessa M. Brown;Michael N. Hallquist;Alexandre Y. Dombrovski - 通讯作者:
Alexandre Y. Dombrovski
Alexandre Y. Dombrovski的其他文献
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{{ truncateString('Alexandre Y. Dombrovski', 18)}}的其他基金
Neurocomputational studies of mood-related momentum dynamics linking reward learning, valuation and responsivity
连接奖励学习、评估和反应性的情绪相关动量动态的神经计算研究
- 批准号:
10662215 - 财政年份:2020
- 资助金额:
$ 68.17万 - 项目类别:
Neurocomputational studies of mood-related momentum dynamics linking reward learning, valuation and responsivity
连接奖励学习、评估和反应性的情绪相关动量动态的神经计算研究
- 批准号:
10058394 - 财政年份:2020
- 资助金额:
$ 68.17万 - 项目类别:
Neurocomputational studies of mood-related momentum dynamics linking reward learning, valuation and responsivity
连接奖励学习、评估和反应性的情绪相关动量动态的神经计算研究
- 批准号:
10441498 - 财政年份:2020
- 资助金额:
$ 68.17万 - 项目类别:
Neurocomputational studies of mood-related momentum dynamics linking reward learning, valuation and responsivity
连接奖励学习、评估和反应性的情绪相关动量动态的神经计算研究
- 批准号:
10250538 - 财政年份:2020
- 资助金额:
$ 68.17万 - 项目类别:
Cognitive and Affective Neuroscience of Decision-Making in Late-Life Suicide
晚年自杀决策的认知和情感神经科学
- 批准号:
8301681 - 财政年份:2009
- 资助金额:
$ 68.17万 - 项目类别:
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