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Mechanisms of Visual Encoding and Plasticity in Anterior Cingulate Cortex

前扣带皮层视觉编码和可塑性机制

基本信息

批准号：
10188546
负责人：
Michael S Sidorov
金额：
$ 23.64万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188546
关键词：
Angelman Syndrome Anterior Area Basic Science Behavior Behavioral Biological Models Boston Brain Calcium Chronic Clinical Contralateral Data Defect Detection Development Plans Disease Educational process of instructing Emotional Eye Faculty Foundations Genes Genetic Models Goals Grant Image Impairment Individual Ipsilateral Knowledge Lateral Geniculate Body Learning Longitudinal Studies Measures Mentors Modification Monitor Mus Neocortex Neurodevelopmental Disorder Neurons Neurosciences Research Oranges Pattern Phase Phenotype Positioning Attribute Prefrontal Cortex Process Property Research Research Personnel Secure Sensory Slice Stimulus Syndrome Testing Thalamic structure Training Translational Research UBE3A gene Universities Vision Visual Visual Cortex Vocational Guidance Work Writing area striata autism spectrum disorder behavioral impairment behavioral phenotyping career career development cingulate cortex cognitive control experience experimental study gain of function mutation improved in vivo loss of function mutation mouse model novel optogenetics programs response risk variant sequence learning skills tenure track tool two-photon visual information visual process visual processing visual stimulus

项目摘要

PROJECT SUMMARY/ABSTRACT Mouse primary visual cortex (V1) is capable of encoding visual stimuli and undergoing bidirectional plasticity coincident with patterned visual experience. The prefrontal anterior cingulate cortex (ACC) receives input from visual cortex, but mechanisms of visual encoding and experience-dependent plasticity in ACC are not well- understood. The goal of the proposed research is to define how ACC encodes and adapts to patterned visual experience. During the K99 phase, I will pair in vivo and ex vivo recordings with optogenetic and chemogenetic circuit manipulations to study how ACC microcircuits encode visual input. K99 training in two-photon calcium imaging will enable longitudinal studies of how individual neurons adapt to visual experience during the R00 phase. As abnormal sensory processing is a common feature of autism spectrum disorder, further R00 research will use approaches developed during K99 training to assess ACC microcircuit function in single-gene mouse models of autism. My long-term career goals are to advance basic knowledge of visual processing and to improve the lives of individuals with neurodevelopmental disorders through a collaborative program of basic and translational research. To achieve my goal of securing a tenure track faculty position as an independent researcher in neuroscience research, I have developed a comprehensive career development plan with the support of co-mentors Dr. Ben Philpot and Dr. Spencer Smith (UNC) and collaborators Dr. Paul Manis (UNC) and Dr. Jeff Gavornik (Boston University). This plan includes a) technical training in two-photon imaging, b) collaborative projects, c) training in presentation skills, d) training in mentoring skills, e) training in grant writing, f) career guidance, g) clinical exposure, h) formal coursework, i) teaching opportunties, and j) progress monitoring and evalulation.

项目总结/文摘