Fear and anxiety circuit mechanisms in anterior hypothalamic nucleus

项目摘要/摘要 急性严重压力在塑造心理健康方面起着关键作用，使个人容易患上一系列 令人衰弱的疾病，包括创伤后应激障碍和焦虑症。这些条件是 难以治疗和可获得的药物疗效有限。因此，非常需要 发现新的治疗方法。了解大脑如何处理压力的价态(即大小) 经验对于确定新的生物学干预点至关重要。这是因为它的价态 应激性事件强烈影响其对疾病相关行为的持久影响。在这里，我们建议 为了探索下丘脑前核(Ahn)的贡献--一个以前 几乎没有受到关注--对压力经历的感知价值和持久影响。

Project Summary/Abstract Acute severe stress plays a pivotal role in shaping mental health, predisposing individuals to an array of debilitating conditions, including post-traumatic stress disorder and anxiety disorders. These conditions are difficult to treat and available pharmaceuticals are of limited efficacy. There is therefore a great need to discover novel treatments. Understanding how the brain processes the valence (i.e., magnitude) of stressful experiences is critical for identifying new biological points of intervention. This is because the valence of stressful events strongly influences their lasting consequences on disease-related behavior. Here, we propose to explore the contribution of the anterior hypothalamic nucleus (AHN) – a brain region that has previously received little attention – to the perceived valence and lasting impacts of stressful experiences.