Fear and anxiety circuit mechanisms in anterior hypothalamic nucleus

下丘脑前核的恐惧和焦虑环路机制

• 批准号: 10789153
• 负责人: Denise Jade Cai
• 金额: $ 66.2万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10789153
• 关键词: Acute; Amygdaloid structure; Animals; Anxiety; Anxiety Disorders; Area; Attention; Aversive Stimulus; Behavior; Biological; Brain; Brain region; Control Animal; Data; Disease; Event; Exposure to; Fright; Glutamates; Hippocampus; Image; Immediate-Early Genes; Individual; Intervention; Long-Term Effects; Maps; Medial; Mediating; Memory; Mental Health; Mus; Names; Negative Valence; Neurons; Pharmacologic Substance; Play; Post-Traumatic Stress Disorders; Prefrontal Cortex; Process; Regulation; Research; Role; Shapes; Site; Stress; Stressful Event; Testing; Variant; Work; anterior hypothalamic nucleus; anxiety-like behavior; attentional modulation; behavior test; cell type; design; experience; in vivo calcium imaging; novel; optogenetics; response; stressor

Project Summary/Abstract Acute severe stress plays a pivotal role in shaping mental health, predisposing individuals to an array of debilitating conditions, including post-traumatic stress disorder and anxiety disorders. These conditions are difficult to treat and available pharmaceuticals are of limited efficacy. There is therefore a great need to discover novel treatments. Understanding how the brain processes the valence (i.e., magnitude) of stressful experiences is critical for identifying new biological points of intervention. This is because the valence of stressful events strongly influences their lasting consequences on disease-related behavior. Here, we propose to explore the contribution of the anterior hypothalamic nucleus (AHN) – a brain region that has previously received little attention – to the perceived valence and lasting impacts of stressful experiences.

项目总结/文摘