Infant multisensory integration and speech development: A multimodal imaging study

婴儿多感觉整合和言语发展：多模态成像研究

• 批准号: 10191411
• 负责人: Guannan Shen
• 金额: $ 12.32万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10191411
• 关键词: 2 year old; 3 year old; Acoustics; Adult; Age; Age-Months; Area; Auditory; Auditory area; Award; Behavior assessment; Behavioral; Brain; Brain imaging; Brain region; Broca' s area; Child; Clinical; Code; Comb animal structure; Complex; Data; Databases; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Early Diagnosis; Early Intervention; Equipment and supply inventories; Face; Failure; Future; Gestational Age; Goals; Imaging Techniques; Incidence; Individual; Infant; Inferior; Intervention; K-Series Research Career Programs; Knowledge; Language; Language Delays; Language Development; Language Development Disorders; Language Disorders; Learning; Life; Linguistics; Link; Lip structure; Magnetoencephalography; Measures; Modality; Movement; Multimodal Imaging; Parents; Pathway interactions; Perception; Play; Population; Premature Infant; Prevalence; Process; Research; Resources; Risk; Role; Sampling; Scientist; Sensory; Speech; Speech Delay; Speech Development; Speech Disorders; Speech Sound; Stimulus; Structure; System; Technology; Testing; Time; Training; Training Support; Visual; Visual Cortex; Voice; audiovisual speech; base; behavioral outcome; brain behavior; imaging study; improved; indexing; language outcome; multimodality; multisensory; neural circuit; neural correlate; neuromechanism; neurophysiology; recruit; relating to nervous system; response; speech processing; visual information; visual speech; visual stimulus; vocalization; white matter

Project summary Multisensory integration plays a central role in speech acquisition as most infants harness auditory and visual information to crack the language code. Disruption to multisensory processing in the first year of life is associated with later speech delay and language disorders. Although research in adults has identified several brain measures and brain regions involved in multisensory processing, how this process emerges in infants and how it is related to behavioral outcome, especially language outcome, is very much unknown. The primary objective of this Career Development Award is to support training in multimodal brain imaging in order to examine functional and structural mechanisms of multisensory development and their associations with speech acquisition and language outcomes in typically developing (TD) and preterm infants. Improved understanding of normal multisensory integration and deviations from normal will inform early diagnosis and intervention strategies for infant speech delay/disorders. The proposed award builds upon the candidate’s prior training in speech processing and multisensory perception, extending this knowledge into the domains of infant brain imaging (function and structure) and infant vocalization analysis. Aim 1 characterizes the neural bases of multisensory integration in TD and preterm infants and investigates brain-behavior associations in infants 9 to 12 months old (Time 1). Specifically, Aim 1a investigates cortical neural processes (obtained via infant magnetoencephalography (MEG)) following congruent versus incongruent audiovisual speech stimuli, with a focus on alpha activity in auditory cortex and gamma activity in Broca’s area. Aim 1b examines whether the MEG measures of multisensory processing as well as DTI measures of structural connectivity are associated with pre-verbal vocalization (i.e., canonical babbling). Aim 2b tests whether the brain measures and vocalization assessment in the first year of life predict speech/language outcome at 24 months. Finally, Exploratory Aim 3 directly compares these measures in preterm infants versus TD infants. Although the K01 study investigate complex multisensory speech mechanisms, the research is feasible given the candidate’s background and the available institutional resources (scientists and technology). Study findings are expected to inform theoretical modals of early speech development as well as provide the candidate pilot data for future R01 clinical brain imaging studies on atypical multisensory development in at-risk infant populations. The award will also provide the candidate the opportunity to obtain training in behavioral assessment of speech/language development and cutting-edge multimodal imaging techniques. The research performed and training provided by this award is critical to the candidate’s long-term goal of conducting independent research on the neurophysiological mechanisms of speech/language development and disorders.

项目概要 多感觉整合在语言习得中发挥着核心作用，因为大多数婴儿都利用听觉和视觉 破解语言密码的信息。生命第一年多感官处理的中断是 与后来的言语迟缓和语言障碍有关。尽管针对成人的研究已经确定了一些 大脑测量和参与多感觉处理的大脑区域，这个过程如何在婴儿中出现 它与行为结果（尤其是语言结果）之间的关系目前还非常未知。这 该职业发展奖的主要目标是支持多模式脑成像培训 为了检查多感觉发育的功能和结构机制及其 与典型发育 (TD) 和早产儿的言语习得和语言结果的关联 婴儿。提高对正常多感觉整合和偏离正常的理解将提供信息 婴儿言语迟缓/障碍的早期诊断和干预策略。 拟议的奖项建立在候选人之前在语音处理和多感官方面的培训基础上 感知，将这些知识扩展到婴儿大脑成像（功能和结构）领域 婴儿发声分析。目标 1 描述了 TD 中多感觉整合的神经基础 早产儿并调查 9 至 12 个月大婴儿的大脑行为关联（时间 1）。 具体来说，目标 1a 研究皮质神经过程（通过婴儿脑磁图获得） （MEG））遵循一致与不一致的视听语音刺激，重点关注α活动 布罗卡区的听觉皮层和伽玛活动。目标 1b 检查 MEG 是否测量 多感官处理以及结构连接的 DTI 测量与前语言相关 发声（即规范的胡言乱语）。 Aim 2b测试大脑是否测量和发声评估 生命第一年预测 24 个月时的言语/语言结果。最后直接探索目标3 比较了早产儿和 TD 婴儿的这些测量值。尽管 K01 研究调查了复杂的 多感官言语机制，考虑到候选人的背景和可用的信息，该研究是可行的 机构资源（科学家和技术）。研究结果有望为理论模式提供信息 早期语音开发并为未来R01临床脑成像提供候选试点数据 关于高危婴儿群体非典型多感觉发育的研究。 该奖项还将为候选人提供获得行为评估培训的机会 语音/语言发展和尖端的多模态成像技术。进行的研究和 该奖项提供的培训对于候选人进行独立研究的长期目标至关重要 关于言语/语言发展和障碍的神经生理学机制。