EEG Signatures of ICU Delirium and Post-ICU ADRD

ICU 谵妄和 ICU 术后 ADRD 的脑电图特征

• 批准号: 10192328
• 负责人: Shawniqua Williams Roberson
• 金额: $ 18.54万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192328
• 关键词: Academic Medical Centers; Admission activity; Age; Age-Years; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Anesthesia procedures; Anesthetics; Area; Arousal; Award; Biomedical Engineering; Brain; Brain Diseases; Clinical; Clinical Engineering; Clinical Research; Clinical assessments; Cognitive; Communication; Critical Care; Critical Illness; Data; Delirium; Dementia; Development; Development Plans; Dexmedetomidine; Disease; Elderly; Electroencephalography; Electrophysiology (science); Engineering; Ensure; Evolution; Fellowship; Foundations; Frequencies; Funding; Goals; Grant; Hospitalization; Hospitals; Impaired cognition; Inpatients; Intensive Care Units; Intervention; Leadership; Literature; Measurable; Measurement; Measures; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Monitor; Motor; Neurobiology; Neurocognitive; Neurologist; Neurology; Neuropsychology; Operative Surgical Procedures; Outcome; Outcome Assessment; Outcome Measure; Outcomes Research; Patient Monitoring; Patients; Pattern; Performance; Physicians; Physiological; Physiology; Population; Propofol; Quality of life; Recovery; Research; Research Methodology; Research Personnel; Rest; Science; Scientist; Severity of illness; Supervision; Survivors; Techniques; Time; Training; United States; United States National Institutes of Health; Writing; base; brain dysfunction; career; career development; clinical Diagnosis; cognitive function; cognitive neuroscience; cognitive performance; cognitive testing; cohort; design; experience; follow-up; high risk; inattention; indexing; insight; mild cognitive impairment; neurophysiology; neurotransmission; novel; patient oriented; postoperative delirium; predictive modeling; professor; research study; sedative; signal processing; skills; survivorship; tool

PROJECT SUMMARY / ABSTRACT This proposal is for a mentored patient-oriented research career development award for Dr. Shawniqua Williams Roberson, Assistant Professor of Neurology and Bioengineering at Vanderbilt University Medical Center. Dr. Williams Roberson's long-term goal is to establish an independent research career using EEG signal processing techniques to study the neurobiology and neurophysiological indicators of ICU delirium and post-ICU cognitive impairment and dementia, a potentially devastating disorder recognized and funded under the Alzheimer's Disease and related dementias (ADRD) for which older adults are at highest risk. To accomplish this, her objectives during the period of this award are: (1) to develop expertise in the design and implementation of patient-oriented clinical research studies in ICU delirium and post-ICU dementia; (2) to gain experience in the assessment of cognitive function as an outcome measure; and (3) to develop the scientific communication, grant writing and leadership skills to support a successful career as an independent researcher. The central hypothesis of this proposal is that there are objective EEG-based signatures of ICU delirium that predict patterns of post-ICU cognitive impairment and dementia. The specific aims are (1) to characterize quantitatively the resting-state EEG signatures associated with ICU delirium in older adults and (2) to determine the relationship between EEG signatures during recovery from critical illness and post-ICU cognitive performance in this population. The proposed studies will yield critical information to advance our understanding of the neurobiology underlying delirium and its evolution to post-ICU ADRD by informing development of a novel delirium monitoring tool for the ICU and identifying EEG predictors of ADRD in survivors. The results will be used to inform a subsequent R01 validating an EEG-based index of ICU delirium and a prediction model for post-ICU ADRD. The project will be conducted in the Critical Illness, Brain Dysfunction and Survivorship (CIBS) Center and will allow the PI to capitalize on guidance from a world-class mentoring team. Dr. E. Wesley Ely, a renowned expert in clinical research in aging and critical care populations will be primary mentor and supervise the clinical research methodology. Dr. James C. Jackson, a world leader in neurocognitive outcomes research, will guide the conduct, analysis and interpretation of cognitive assessments. Dr. Mayur Patel, PI of multiple ongoing NIH-funded studies investigating long-term outcomes after critical care, will oversee professional development in scientific communication, grant writing and leadership. This project will thus provide a platform for Dr. Williams Roberson to establish preliminary data and clinical research skills to launch an independent research career at the intersection of critical illness, cognitive neuroscience, engineering and clinical neurophysiology, where she is uniquely poised to make a durable impact for ICU survivors.

项目摘要/摘要 这项提议是为肖尼卡博士设立一个以患者为导向的指导研究职业发展奖。 威廉姆斯·罗伯逊，范德比尔特大学医学院神经学和生物工程助理教授 中心。威廉姆斯·罗伯逊博士的长期目标是利用脑电建立独立的研究生涯 应用信号处理技术研究ICU妄想症的神经生物学和神经生理学指标 ICU后认知障碍和痴呆症，一种潜在的破坏性疾病，由 阿尔茨海默氏症和相关痴呆症(ADRD)是老年人风险最高的疾病。至 要做到这一点，她在此奖项期间的目标是：(1)在设计和设计方面发展专业知识 实施以病人为中心的ICU妄想症和ICU后痴呆的临床研究；(2)获得 在评估认知功能作为结果测量方面的经验；以及(3)发展科学的 沟通、写作和领导技能，以支持独立人士的成功职业生涯 研究员。这一建议的中心假设是，ICU存在客观的基于脑电的特征 精神错乱预测ICU后认知障碍和痴呆症的模式。具体目标是(1) 定量表征与ICU精神错乱相关的老年人静息状态脑电特征和 (2)确定危重病恢复期脑电特征与ICU后脑电特征的关系 在这一群体中的认知表现。拟议的研究将产生关键信息，以推进我们的 认识妄想的神经生物学基础及其向ICU后ADRD的演变 ICU新型妄想监测工具的研制及ADRD脑电预测指标的确定 幸存者。结果将被用来通知随后的R01，以验证基于脑电的ICU精神错乱指数 ICU后ADRD的预测模型。该项目将在危重疾病大脑中进行 功能障碍和生存(CIBS)中心，并将使PI利用世界级的指导 指导团队。E·韦斯利·伊利博士，老龄化和重症护理人群临床研究的著名专家 将成为临床研究方法论的主要导师和监督者。詹姆斯·C·杰克逊博士，世界领袖 在神经认知结果研究中，将指导认知的进行、分析和解释 评估。美国国立卫生研究院资助的多项调查长期结果的研究 经过重症护理后，将监督科学交流方面的专业发展，拨款和 领导力。因此，该项目将为威廉姆斯·罗伯逊博士提供一个平台，以建立初步数据和 临床研究技能在危重疾病、认知交叉路口开展独立研究事业 神经科学、工程学和临床神经生理学，她在这些领域独一无二地准备让 对重症监护室幸存者的影响。