EEG Signatures of ICU Delirium and Post-ICU ADRD

ICU 谵妄和 ICU 术后 ADRD 的脑电图特征

• 批准号: 10402387
• 负责人: Shawniqua Williams Roberson
• 金额: $ 18.45万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10402387
• 关键词: Academic Medical Centers; Admission activity; Age; Age-Years; Aging; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Anesthesia procedures; Anesthetics; Area; Arousal; Award; Biomedical Engineering; Brain; Brain Diseases; Clinical; Clinical Engineering; Clinical Research; Clinical assessments; Cognitive; Communication; Critical Care; Critical Illness; Data; Delirium; Dementia; Development; Development Plans; Dexmedetomidine; Disease; Elderly; Electroencephalography; Electrophysiology (science); Engineering; Ensure; Evolution; Fellowship; Foundations; Frequencies; Funding; Goals; Grant; Hospitalization; Hospitals; Impaired cognition; Inpatients; Intensive Care Units; Intervention; Leadership; Literature; Measurable; Measurement; Measures; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Monitor; Motor; Neurobiology; Neurocognitive; Neurologist; Neurology; Neuropsychology; Operative Surgical Procedures; Outcome; Outcome Assessment; Outcome Measure; Outcomes Research; Patient Monitoring; Patients; Pattern; Performance; Physicians; Physiological; Physiology; Population; Propofol; Quality of life; Recovery; Research; Research Methodology; Research Personnel; Rest; Science; Scientist; Severity of illness; Supervision; Survivors; Techniques; Time; Training; United States; United States National Institutes of Health; Writing; base; brain dysfunction; career; career development; clinical diagnosis; cognitive function; cognitive neuroscience; cognitive performance; cognitive testing; cohort; design; experience; follow-up; high risk; inattention; indexing; insight; mild cognitive impairment; neurophysiology; neurotransmission; novel; patient oriented; postoperative delirium; predictive modeling; professor; research study; sedative; signal processing; skills; survivorship; tool

PROJECT SUMMARY / ABSTRACT This proposal is for a mentored patient-oriented research career development award for Dr. Shawniqua Williams Roberson, Assistant Professor of Neurology and Bioengineering at Vanderbilt University Medical Center. Dr. Williams Roberson's long-term goal is to establish an independent research career using EEG signal processing techniques to study the neurobiology and neurophysiological indicators of ICU delirium and post-ICU cognitive impairment and dementia, a potentially devastating disorder recognized and funded under the Alzheimer's Disease and related dementias (ADRD) for which older adults are at highest risk. To accomplish this, her objectives during the period of this award are: (1) to develop expertise in the design and implementation of patient-oriented clinical research studies in ICU delirium and post-ICU dementia; (2) to gain experience in the assessment of cognitive function as an outcome measure; and (3) to develop the scientific communication, grant writing and leadership skills to support a successful career as an independent researcher. The central hypothesis of this proposal is that there are objective EEG-based signatures of ICU delirium that predict patterns of post-ICU cognitive impairment and dementia. The specific aims are (1) to characterize quantitatively the resting-state EEG signatures associated with ICU delirium in older adults and (2) to determine the relationship between EEG signatures during recovery from critical illness and post-ICU cognitive performance in this population. The proposed studies will yield critical information to advance our understanding of the neurobiology underlying delirium and its evolution to post-ICU ADRD by informing development of a novel delirium monitoring tool for the ICU and identifying EEG predictors of ADRD in survivors. The results will be used to inform a subsequent R01 validating an EEG-based index of ICU delirium and a prediction model for post-ICU ADRD. The project will be conducted in the Critical Illness, Brain Dysfunction and Survivorship (CIBS) Center and will allow the PI to capitalize on guidance from a world-class mentoring team. Dr. E. Wesley Ely, a renowned expert in clinical research in aging and critical care populations will be primary mentor and supervise the clinical research methodology. Dr. James C. Jackson, a world leader in neurocognitive outcomes research, will guide the conduct, analysis and interpretation of cognitive assessments. Dr. Mayur Patel, PI of multiple ongoing NIH-funded studies investigating long-term outcomes after critical care, will oversee professional development in scientific communication, grant writing and leadership. This project will thus provide a platform for Dr. Williams Roberson to establish preliminary data and clinical research skills to launch an independent research career at the intersection of critical illness, cognitive neuroscience, engineering and clinical neurophysiology, where she is uniquely poised to make a durable impact for ICU survivors.

项目总结/摘要 这项建议是为指导病人为导向的研究职业发展奖博士肖尼夸 威廉姆斯·罗伯逊（Williams Roberson），范德比尔特大学医学院神经病学和生物工程助理教授 中心威廉姆斯罗伯森博士的长期目标是建立一个独立的研究生涯使用脑电图 信号处理技术研究ICU谵妄的神经生物学和神经生理学指标， ICU后认知障碍和痴呆，一种潜在的破坏性疾病， 阿尔茨海默病和相关痴呆症（ADRD），老年人处于最高风险。到 为了实现这一目标，她在这个奖项期间的目标是：（1）发展设计方面的专业知识， 在ICU谵妄和ICU后痴呆中实施以患者为导向的临床研究;（2）获得 在认知功能作为结果测量的评估方面的经验;以及（3）开发科学的 沟通，赠款写作和领导能力，以支持作为一个独立的成功的职业生涯 研究员该建议的中心假设是ICU存在客观的基于EEG的签名 谵妄可预测ICU后认知障碍和痴呆的模式。具体目标是：（1） 定量描述老年人ICU谵妄相关的静息状态EEG特征， (2)确定危重病恢复期间和ICU后的EEG特征之间的关系 在这个人群中的认知表现。拟议的研究将产生关键信息，以推进我们的 了解谵妄的神经生物学基础及其演变为ICU后ADRD， 为ICU开发一种新的谵妄监测工具，并确定ADRD的EEG预测因子， 幸存者结果将用于通知后续R 01，以验证基于EEG的ICU谵妄指数 和ICU后ADRD的预测模型。该项目将在危重病，脑 功能障碍和生存（CIBS）中心，并将允许PI利用世界级的指导， 指导团队。Dr. E.韦斯利伊利，一个著名的专家，在临床研究中的老龄化和重症监护人群 将主要指导和监督临床研究方法。James C.博士杰克逊，一位世界领袖 在神经认知结果的研究，将指导行为，分析和解释的认知 评估。Mayur Patel博士，多项正在进行的NIH资助的研究长期结局的PI 在重症监护后，将监督科学交流，赠款写作和 领导因此，该项目将为威廉姆斯罗伯森博士提供一个平台，以建立初步数据， 临床研究技能，在危重病，认知， 神经科学，工程和临床神经生理学，在那里她是独一无二的准备作出持久的 对ICU幸存者的影响。