Brain Healthy Soul Food Diet Intervention Among Older African Americans

老年非洲裔美国人大脑健康灵魂食物饮食干预

• 批准号: 10192195
• 负责人: Ashley Richelle Shaw
• 金额: $ 12.85万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192195
• 关键词: Address; Adherence; Adult; Affect; African American; Alzheimer' s Disease; Alzheimer' s disease risk; Area; Attitude; Behavior; Behavioral; Biological Markers; Blood Pressure; Body Composition; Body fat; Brain; Burn injury; Caucasians; Cause of Death; Cholesterol; Chronic; Clinical Trials Design; Cognition; Cognitive; Communities; Consumption; Crystallization; DASH diet; Data; Development; Diabetes Mellitus; Diet; Dietary Intervention; Dietary Practices; Disease; Environment; Evaluation; Focus Groups; Food; Food Preferences; Geographic Locations; Goals; Health Status; High Prevalence; Impaired cognition; Intervention; Knowledge; Life Style; Mediterranean Diet; Mentored Research Scientist Development Award; Mentors; Mentorship; Nerve Degeneration; Not Hispanic or Latino; Nutritional; Obesity; Outcome; Participant; Pilot Projects; Play; Prevention strategy; Public Health; Recommendation; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk; Risk Factors; Role; Surveys; Testing; Time; Training; Work; acceptability and feasibility; age related; base; brain health; cardiovascular risk factor; career development; cognitive function; cognitive testing; community based research; cultural values; design; dietary; dietary adherence; effective intervention; efficacy testing; ethnic minority population; experience; good diet; improved; lifestyle intervention; modifiable risk; nutrition education; personalized approach; prevent; racial and ethnic; therapy design; therapy development

PROJECT SUMMARY AD is the 4th leading cause of death among African Americans and African Americans are two to three times more likely to develop AD compared to non-Hispanic Caucasians. Given the high prevalence of diabetes and obesity and the emerging evidence that up to 50% of AD cases are a result of modifiable risk factors, prevention strategies may play a critical role in reducing AD risk for AAs. Previous research has indicated that adherence to healthy diets such as the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurogenerative Delay (MIND) help slow cognitive decline among adults 65 years and older. However, adherence and acceptability of such diets remain low among African Americans, due to lack of cultural considerations. Thus, there is a critical need for the development of a culturally adapt brain healthy diet that is congruent with African American cultural values and food preferences. Creating a culturally relevant brain healthy diet for African Americans, will enhance both acceptability and adherence which are essential to lifestyle behavioral changes. The proposed project aligns well with the NIA Strategic Directions for Research Goal C-3: Develop interventions for treating, preventing, or mitigating the impact of age-related diseases and condition; by meaningfully incorporating a culturally tailored approach to an adapted diet intervention to reduce the risk of cardiovascular risk factors related to AD and to maintain independence among older African Americans. Specifically, Dr. Shaw plans to address the following specific aims (1) develop an adapted brain healthy soul food diet intervention; (2) pilot test an adapted brain- healthy soul food diet intervention; (3) explore the effect of the adapted brain-healthy soul food diet intervention of cognitive function as preliminary data to design a RCT. To achieve these specific aims, Dr. Shaw will work with a highly skilled mentorship team (Drs. Jeffrey Burns, Debra Sullivan, and Janette Berkley-Patton) and consultants (Dr. Crystal Glover and Mr. Broderick Crawford) to build four areas of expertise relevant to the research agenda: (1) ARDR clinical trial design and implementation (2) cultural tailoring of established diets (3) qualitative design and analysis (4) community-based research design. The K01 award will enhance Dr. Shaw's capabilities to successfully transition into an independent researcher who has expertise in the development and evaluation of culturally tailored lifestyle interventions to reduce AD risk among African Americans. Results of the proposed research will enhance our understanding of how AA culture influences current dietary practice, adherence, acceptability, and feasibility of a brain-healthy diet for older AA. Results will also positively impact the development of R01 scale RCT to test the efficacy of an adapted brain-healthy diet intervention among older AA across a larger geographical area.

项目总结 AD是非洲裔美国人的第四大死因，是非洲裔美国人的两到三倍 与非西班牙裔白人相比，更有可能患上阿尔茨海默病。鉴于糖尿病的高患病率和 肥胖和新出现的证据表明，高达50%的AD病例是可改变的风险因素的结果， 预防策略可能在降低AA的AD风险方面发挥关键作用。此前的研究表明， 坚持健康饮食，如地中海饮食，控制高血压的饮食方法(DASH)， 地中海式神经生成延迟(思维)干预有助于减缓 65岁及以上的成年人。然而，非洲人对这种饮食的坚持和接受程度仍然很低。 美国人，由于缺乏文化考量。因此，迫切需要制定一项 在文化上适应与非裔美国人文化价值观和食物相一致的大脑健康饮食 偏好。为非裔美国人创造一种与文化相关的大脑健康饮食，将使两者都得到提升 可接受性和坚持性对生活方式行为的改变至关重要。拟议的项目与 熟悉NIA研究目标C-3的战略方向：开发治疗、预防或治疗的干预措施 减轻与年龄相关的疾病和状况的影响；通过有意义地纳入文化上量身定制的 降低AD相关心血管危险因素风险的适应性饮食干预方法探讨 在年长的非裔美国人中保持独立。具体地说，肖博士计划解决以下问题 具体目标(1)开发适应大脑的健康灵魂食物饮食干预；(2)初步测试适应的大脑- 健康心灵饮食干预；(3)探讨适应性脑-心灵健康饮食干预的效果 认知功能作为设计随机对照试验的初步数据。为了实现这些具体目标，肖博士将努力 拥有高技能的指导团队(Jeffrey Burns博士、Debra Sullivan博士和Janette Berkley-Patton博士)以及 顾问(克里斯特尔·格洛弗博士和布罗德里克·克劳福德先生)建立与以下四个领域相关的专业知识 研究议程：(1)ARDR临床试验设计和实施(2)既定饮食的文化定制(3) 定性设计与分析(4)社区研究设计。K01奖将加强Shaw博士的 成功过渡到具有开发专业知识的独立研究人员的能力 以及评估文化定制的生活方式干预措施，以降低非裔美国人患AD的风险。结果 这项拟议的研究将增强我们对AA文化如何影响当前饮食实践的理解， 老年再障患者大脑健康饮食的依从性、可接受性和可行性。结果也将产生积极的影响 R01量表RCT的开发，以测试适应性脑健康饮食干预的效果 较年长的AA横跨更大的地理区域。