Non-invasive characterization of secondary brain injuries after severe acute brain injury using integrated functional optical imaging and electroencephalography

使用集成功能光学成像和脑电图对严重急性脑损伤后继发性脑损伤进行非侵入性表征

• 批准号: 10198065
• 负责人: Ulas Sunar
• 金额: $ 7.94万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198065
• 关键词: Acute; Acute Brain Injuries; Address; Blood flow; Brain; Brain Injuries; Brain region; Caring; Cerebrovascular Circulation; Cerebrum; Clinical; Color; Computer software; Custom; Device or Instrument Development; Devices; Diffuse; Diffusion; Electroencephalogram; Electroencephalography; Enrollment; FDA approved; Feedback; Goals; Gold; Human; Hypoxia; Injury; Intensive Care Units; Intervention; Investigation; Ischemia; Ischemic Stroke; Lead; Location; Measurement; Measures; Medicine; Metabolic; Monitor; Optics; Outcome; Oxygen; Patients; Physiologic pulse; Pilot Projects; Populations at Risk; Public Health; Records; Reporting; Scalp structure; Secondary to; Seizures; Severities; Signal Transduction; Site; Spectrum Analysis; Subarachnoid Hemorrhage; Survivors; System; TBI Patients; Technology; Testing; Time; Tissues; Traumatic Brain Injury; Trephine hole; base; brain electrical activity; brain tissue; cerebral oxygenation; computerized data processing; cost; data acquisition; data fusion; effective therapy; electric field; hemodynamics; high risk; imaging approach; improved; injury-related death; instrument; instrumentation; interest; light intensity; monitoring device; multidisciplinary; multimodality; optical imaging; programs; temporal measurement; tissue oxygenation; tool; validation studies

PROJECT SUMMARY/ABSTRACT There is a need for improved monitoring tools for the brain in TBI patients. Survivors of severe brain injuries may require care in an intensive care unit (ICU), where the brain is vulnerable to secondary brain injuries, defined by a mismatch between the metabolic supply and demand that creates ischemia. Existing technologies for monitoring secondary brain injuries are inadequate: continuous scalp EEG is noninvasive and detects seizures, but only indirectly reflects cerebral blood flow compromise. In some cases, invasive probes are placed within the brain to detect cerebral blood flow and brain tissue oxygenation directly. However, this strategy can be risky and only monitors a small region of the brain. Thus, there is a need for real-time, noninvasive, multimodal measurements of the brain’s electrical activity, oxygenation, and hemodynamics in humans. Our goal is to address this need through combined measurements of EEG and functional optical spectroscopy (EEG-Optical) instrumentation and analysis to provide a complementary fusion of data on brain activity and function. EEG records the brain’s local electrical field potentials with exquisite temporal resolution. Optical imaging uses low- intensity light to quantify cerebral blood flow (CBF) and cerebral oxygen saturation (StO2). In Aim 1, we will adapt our DCS current instrument for continuous for longitudinal monitoring of TBI patients alongside to clinical instruments. In Aim2, we will perform a validation study to evaluate this new, integrated, noninvasive technology by comparing directly with the gold standard, FDA-approved invasive measurement of brain blood flow and oxygenation in patients with TBI undergoing clinically-standard invasive monitoring. This study will lead directly to further device development and investigational device application, with a goal for a device that will allow for brain blood flow and oxygenation monitoring in all patients with acute brain injuries in order to guide management.

项目总结/文摘

项目成果

Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report.

• DOI: 10.3390/brainsci11081093
• 发表时间: 2021-08-20
• 期刊: Brain sciences
• 影响因子: 3.3
• 作者: Poon CS;Rinehart B;Langri DS;Rambo TM;Miller AJ;Foreman B;Sunar U
• 通讯作者: Sunar U

Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.

• DOI: 10.3390/brainsci13101365
• 发表时间: 2023-09-25
• 期刊: Brain sciences
• 影响因子: 3.3
• 作者: Langri DS;Sunar U
• 通讯作者: Sunar U