Biostatistics and Research Information Systems Core (BIC)

在米勒博士和IP博士的持续领导下，WF OAIC生物统计和研究的目标是 信息系统核心（BIC）是建立在其杰出的成功，在生物统计合作和扩大 为老龄化研究量身定制的统计/信息学工具。拟议的核心由一个高度 具有观察性、试验性和干预性研究设计和管理专业知识的合格研究者/工作人员 研究，集中和分散的数据管理，表格设计和数据处理，心理测量学， 对多项研究设计的数据进行统计分析，并开发新的统计方法。这些 个人致力于WF OAIC的计划目标：1）发现新的共同途径 导致与年龄相关的身体功能下降和残疾; 2）制定，评估和完善策略 残疾治疗和预防; 3）将经过验证的战略转化为传统研究之外的战略 环境; 4）培养下一代专注于残疾治疗的研究领导者， 预防通过与所有其他OAIC核心的密切合作，我们提出了四个具体目标： 1.作为研究者参与WF OAIC项目，包括：4项试点研究，2项开发研究 项目和10个与WF OAIC目标和主题有关的外部资助项目。作为共同调查员， BIC成员积极参与研究设计和实施。其作用包括招聘 监查、随机化和安全性监查;样本量确定;数据管理; 统计分析和解释;以及介绍/公布结果。 2.在培训OAIC支持的学者在设计，规划，进行， 分析与老龄化有关的研究项目。 BIC还将通过Specific Aims 3扩展其在创新发现和评估方面的良好记录 和4，即： 3.继续生物统计学应用/方法开发，以解决与衰老相关的分析问题 research. 4.开发独特的研究信息收集系统，用于老年人研究 参与者，并将其转化为社区和诊所为基础的设置。

Under the continuing leadership of Drs. Miller and IP, The goal of the WF OAIC Biostatistics and Research Information Systems Core (BIC) is to build on its outstanding success in biostatistical collaboration and expand statistics/informatics tools tailored to research in aging. The proposed Core is comprised of a team of highly qualified investigators/staff with expertise in the design and management of observational, pilot and interventional studies, centralized and decentralized data management, forms design and data processing, psychometrics, statistical analysis of data from multiple study designs, and development of novel statistical methods. These individuals are committed to the WF OAIC's programmatic aims to: 1) discover new common pathways contributing to age-related declines in physical function and disability; 2) develop, evaluate, and refine strategies for disability treatment and prevention; 3) translate proven strategies beyond the traditional research environments; and 4) train the next generation of research leaders focused on disability treatment and prevention. In close collaboration with all other OAIC cores, we propose four Specific Aims: 1. To participate as investigators for WF OAIC projects including: 4 Pilot Studies, 2 Developmental Projects, and 10 Externally-Funded Projects related to WF OAIC aims and themes. As co-investigators, BIC members are actively involved in study design and conduct. Their roles include recruitment monitoring, randomization, and safety monitoring; sample size determination; data management; statistical analysis and interpretation; and presentation/publication of results. 2. To play an integral role in training OAIC-supported scholars in the design, planning, conduct, and analysis of aging-related research projects. The BIC will also extend its strong record of innovative discovery and evaluation through Specific Aims 3 and 4, which are to: 3. Continue biostatistical applications/methods development for analytical issues associated with aging research. 4. Develop unique research information collection systems for implementation in studies of older participants, and translate these into community- and clinic-based settings.