BIOSTATISTICS AND DATA MANAGEMENT CORE

生物统计和数据管理核心

• 批准号: 7462848
• 负责人: Michael E. Miller
• 金额: $ 13.23万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7462848
• 关键词: Address; Adherence; Adipose tissue; Advisory Committees; Affect; Aging; American; Award; Behavioral; Behavioral Sciences; Biological; Biometry; Biostatistical Methods; Body Composition; Clinical; Clinical Research; Clinical Trials Database; Collaborations; Communication; Data; Data Analyses; Data Collection; Databases; Development; Disease; Effectiveness of Interventions; Elderly; Ensure; Faculty; Fatty acid glycerol esters; Funding; Future; Generations; Genetic; Human Resources; Individual; Intervention Studies; Knowledge; Leadership; Measurement; Measures; Molecular; Monitor; Muscle; Muscle function; Obesity; Online Systems; Other Resources; Outcome; Outcome Measure; Participant; Pathway interactions; Performance; Persons; Phase; Physical Function; Pilot Projects; Play; Preparation; Procedures; Process; Psychometrics; Publications; Qualifying; Quality Control; Randomized; Range; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Role; Sample Size; Scheme; Science; Specimen; Statistical Data Interpretation; Statistical Methods; System; Techniques; Testing; Training; Translations; Work; age related; career; computer network; computer program; computerized data processing; data management; design; disability; experience; health training; instrument; interest; member; muscle strength; novel; psychosocial; repository; research and development; sarcopenia; sound; tool

We propose continuation of the Biostatistics and Data Management Core (RC3) for the WFU Older Americans Independence Center (OAIC). The aims of this Core are to provide collaborative support and other resources related to: 1. Study design, sample size determination, data management and statistical analysis for projects (pilot and developmental) investigating the multiple factors that contribute to age-related increases in adiposity, sarcopenia, declines in muscle function, physical function decline and progression to disability. 2. Data management and statistical analyses of muscle strength, physical performance, body composition, fat distribution, and genetic, biological, and disability measures that are added to 9 ongoing externallyfunded projects, 3 pilots, and 2 Research Development projects (initial year). The ongoing close collaborations with the Biolmaging, Clinical Research, Molecular Sciences Resource, and Pilot and Exploratory Studies Cores are an important aspect of this aim. 3. Training of RCDC-supported fellows on the design, planning, conduct and analysis of results of agingrelated research projects. 4. Data management and statistical analyses of existing databases (e.g., REACT II, PIE, TRAIN, Health ABC, MESA, etc.) to allow for re-analyses to address scientific questions on the roles of obesity and muscle loss as determinants of the decline in physical function and progression to physical disability in older persons. 5. Data management and report generation to assist the Clinical Research Core with monitoring recruitment, adherence and retention, and the Molecular Sciences Resource Core with monitoring and promoting of a biological specimen repository. 6. Development of novel biostatistical methods and techniques directly related to analytical issues associated with aging research. 7. Web-based tools useful for the Leadership and Administrative Core to streamline communication and document management within WFU's OAIC. The Biostatistics and Data Management Core will actively collaborate on methodological, statistical, quality control and computational issues, including study design, data collection, computer networking, database management, data analysis, and presentation of results for publication

我们建议继续为WFU老年美国人提供生物统计和数据管理核心（RC 3） 独立中心（OAIC）。该核心的目标是提供协作支持和其他资源 与以下方面有关： 1.研究设计、样本量确定、数据管理和项目统计分析（试点和 发展）调查导致肥胖年龄相关性增加的多种因素， 肌肉减少症、肌肉功能下降、身体功能下降和发展为残疾。 2.肌肉力量、体能、身体成分的数据管理和统计分析 脂肪分布，遗传，生物和残疾措施，增加到9个正在进行的外部资助 项目，3个试点和2个研究开发项目（最初一年）。正在进行的关闭 与生物成像，临床研究，分子科学资源和试点合作， 探索性研究核心是这一目标的一个重要方面。 3.对刚果民盟支助的研究员进行关于老龄问题的设计、规划、开展和结果分析的培训 研究项目。 4.现有数据库的数据管理和统计分析（例如，REACT II，PIE，TRAIN，健康 ABC、梅萨等）允许重新分析，以解决有关肥胖和 肌肉损失作为身体功能下降和身体残疾进展的决定因素， 老年人。 5.数据管理和报告生成，以协助临床研究中心进行监测 招募，坚持和保留，以及分子科学资源核心与监测和 推动建立生物标本储存库。 6.开发与分析问题直接相关的新型生物统计方法和技术 与衰老研究有关。 7.基于网络的工具，有助于领导和行政核心简化沟通， WFU的OAIC内的文件管理。 生物统计学和数据管理核心将在方法、统计、质量、 控制和计算问题，包括研究设计、数据收集、计算机网络、数据库 管理、数据分析和结果公布