Rapid Multi-Channel Serum Profiling for Liver Disease using Fluorescent Nanosensors

使用荧光纳米传感器对肝病进行快速多通道血清分析

基本信息

  • 批准号:
    10357573
  • 负责人:
  • 金额:
    $ 34.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-02-01 至 2024-01-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Rapid Multi-Channel Serum Profiling for Liver Disease using Fluorescent Nanosensors Rapid diagnosis of liver disease is crucial to optimizing patient outcome and minimizing economic impact. Current strategies for detecting liver damage (fibrosis/cirrhosis) use biomarker strategies that are expensive and difficult to translate into Point of Care (PoC) platforms suitable for monitoring of chemotherapy patients and diagnostics for the developing world. In preliminary studies we have demonstrated that simple polymer- based sensor arrays can generate serum ‘signatures’ that can be used to detect liver fibrosis with clinical relevance. In our proposed research we will: Aim 1: Fabricate hairpin polymer-fluorophore conjugates and use these as sensor elements to provide multi- channel outputs serum sensing. Aim 2: Immobilize our polymers onto surfaces to provide prototype sensing systems suitable for clinical and point-of-care use. These sensors will be tested and optimized using model sera. Aim 3: Apply our sensor systems to profile liver fibrosis using pathological samples provided by Rosenberg and Peveler. These studies will focus on detection and staging of liver fibrosis, using statistical methods developed by C. Rotello. Aim 4: Use proteomics with Vachet to characterize protein binding to the polymer sensors, providing mechanistic insight and potentially new biomarkers for fibrosis. The goal of this proposal is to develop prototype sensor systems for diagnosis of LIVER disease; effective achievement of this goal would provide strategies that could be translated to numerous additional disease states.
项目总结/文摘

项目成果

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会议论文数量(0)
专利数量(0)

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VINCENT M. ROTELLO其他文献

VINCENT M. ROTELLO的其他文献

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{{ truncateString('VINCENT M. ROTELLO', 18)}}的其他基金

Rapid Multi-Channel Serum Profiling for Liver Disease using Fluorescent Nanosensors
使用荧光纳米传感器对肝病进行快速多通道血清分析
  • 批准号:
    9886045
  • 财政年份:
    2020
  • 资助金额:
    $ 34.38万
  • 项目类别:
Rapid Multi-Channel Serum Profiling for Liver Disease using Fluorescent Nanosensors
使用荧光纳米传感器对肝病进行快速多通道血清分析
  • 批准号:
    10552591
  • 财政年份:
    2020
  • 资助金额:
    $ 34.38万
  • 项目类别:
Rapid Multi-Channel Serum Profiling for Liver Disease using Fluorescent Nanosensors
使用荧光纳米传感器对肝病进行快速多通道血清分析
  • 批准号:
    10089436
  • 财政年份:
    2020
  • 资助金额:
    $ 34.38万
  • 项目类别:
NIBIB Supplement to Promote Diversity in Health-Related Research: Targeting of Bioorthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages
NIBIB 补充剂促进健康相关研究的多样性:生物正交化疗纳米酶靶向肿瘤相关巨噬细胞
  • 批准号:
    10685774
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:
Supramolecular Bioorthogonal Nanozymes for Targeted Activation of Therapeutics
用于靶向激活治疗药物的超分子生物正交纳米酶
  • 批准号:
    9305701
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages
生物正交化疗纳米酶靶向肿瘤相关巨噬细胞
  • 批准号:
    10210030
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages
生物正交化疗纳米酶靶向肿瘤相关巨噬细胞
  • 批准号:
    10747457
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages
生物正交化疗纳米酶靶向肿瘤相关巨噬细胞
  • 批准号:
    10578840
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:
Immunomodulation through Nanocapsule-Mediated Cytosolic Delivery of siRNA
通过纳米胶囊介导的 siRNA 胞质传递进行免疫调节
  • 批准号:
    9315412
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages
生物正交化疗纳米酶靶向肿瘤相关巨噬细胞
  • 批准号:
    10405110
  • 财政年份:
    2017
  • 资助金额:
    $ 34.38万
  • 项目类别:

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