Patterning the Vertebrate Dentition Through Replacement and Repair
Patterning the Vertebrate Dentition Through Replacement and Repair
批准号:
10356805
负责人:
Jeffery Todd Streelman
金额:
$53.73万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
未结题
起止时间:
2010-03-15 至 2025-02-28
关键词:
Adrenergic AgentsAffectAgeBackBiological AssayBiologyBiomedical EngineeringCadherinsCellsCichlidsDataDefectDentalDental ImplantsDentistryDentitionDevelopmental BiologyEmbryoEpithelialExhibitsFishesGenetic DiseasesGoalsGrowthHomeostasisHumanIncisorKnowledgeLabelMammalsMediatingMesenchymalMesenchymeModelingMolecularMusNatural regenerationNerveNucleosidesOralOropharyngealPathway interactionsPatternPersonsPharmacologyPhysiologic pulsePopulationProblem SolvingProcessRecipeReporterReportingResearchSignal PathwaySignal TransductionStem Cell FactorSystemTaste BudsTaste PerceptionTestingTissuesTooth GermTooth TissueTooth regenerationTooth structureTranslatingVertebratesWNT Signaling PathwayWorld Health OrganizationZebrafishcomparativedeciduous toothhuman old age (65+)improvedinnovationinsightmutantnotch proteinpermanent toothreceptorrecruitregenerativeregenerative biologyrepairedsingle-cell RNA sequencingstem cellstissue regenerationtranscriptome
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
The broad goal of the proposed research is to understand molecular mechanisms of tooth regeneration
and tissue renewal in vertebrates. Our research benefits from explicit integration of experimental systems
(cichlid fishes, zebrafish, mouse) and a unique approach translating new biology from fishes to mammals
and back. In this competitive renewal application, we build on the previous project period to outline three
Specific Aims that fuse unbiased and experimental approaches in multiple vertebrate tooth models to
identify cell populations and molecular signals that direct natural whole-tooth replacement (cichlids and
zebrafish) and mouse incisor tissue renewal. The gaps we aim to fill are significant. One in five humans
presents with a genetic disorder affecting the dentition and nearly 100% develop problems (e.g, cavities)
with age. 30% of people worldwide over the age of 65 lack teeth entirely. Our proposed research will provide
answers to the basic question of how regenerating teeth are partitioned into coordinated zones of renewal
and differentiation, and how mammalian teeth recover from damage. Insights should promote innovative
strategies for bio-inspired regenerative dentistry.
期刊论文(13)
专著(0)
科研奖励(0)
会议论文
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DOI:
10.1016/j.ydbio.2013.02.007
发表时间:
2013-05-15
期刊:
DEVELOPMENTAL BIOLOGY
影响因子:
2.7
作者:
[Fraser, Gareth J., Bloomquist, Ryan F., Streelman, J. Todd]
通讯作者:
Streelman, J. Todd
The genetic basis of a complex functional system.
复杂功能系统的遗传基础。
DOI:
10.1111/j.1558-5646.2012.01688.x
发表时间:
2012
期刊:
Evolution; international journal of organic evolution
影响因子:
--
作者:
[Parnell,NicholasF, Hulsey,CDarrin, Streelman,JTodd]
通讯作者:
Streelman,JTodd
DOI:
10.1016/j.xpro.2023.102117
发表时间:
2023-03-17
期刊:
STAR protocols
影响因子:
--
作者:
[Iranzo J, Gruenhagen G, Calle-Espinosa J, Koonin EV]
通讯作者:
Koonin EV
DOI:
10.1038/s41598-021-92385-8
发表时间:
2021-06-21
期刊:
Scientific reports
影响因子:
4.6
作者:
[Patil C, Sylvester JB, Abdilleh K, Norsworthy MW, Pottin K, Malinsky M, Bloomquist RF, Johnson ZV, McGrath PT, Streelman JT]
通讯作者:
Streelman JT
DOI:
10.1016/bs.ctdb.2015.07.005
发表时间:
2015
期刊:
Current topics in developmental biology
影响因子:
--
作者:
[Streelman JT, Bloomquist RF, Fowler TE]
通讯作者:
Fowler TE
共 8 条
Cellular basis of complex social behavior
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批准号:10701800
-
项目类别:
-
资助金额:$36.18万
-
财政年份:2022
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the vertebrate dentition through replacement and repair
-
批准号:9208130
-
项目类别:
-
资助金额:$31.64万
-
财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the vertebrate dentition through replacement and repair
-
批准号:8504410
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项目类别:
-
资助金额:$33.21万
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财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the Vertebrate Dentition Through Replacement and Repair
-
批准号:8042628
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项目类别:
-
资助金额:$21.52万
-
财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the Vertebrate Dentition Through Replacement and Repair
-
批准号:8231481
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项目类别:
-
资助金额:$21.3万
-
财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the Vertebrate Dentition Through Replacement and Repair
-
批准号:9886232
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项目类别:
-
资助金额:$54.27万
-
财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the vertebrate dentition through replacement and repair
-
批准号:8639518
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项目类别:
-
资助金额:$31.83万
-
财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
Patterning the vertebrate dentition through replacement and repair
-
批准号:9000686
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项目类别:
-
资助金额:$31.71万
-
财政年份:2010
-
负责人:Jeffery Todd Streelman
-
依托单位:
The Cichlid Dentition Integrates Tooth Number and Tooth Shape
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批准号:7146603
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项目类别:
-
资助金额:$22.26万
-
财政年份:2006
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负责人:Jeffery Todd Streelman
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依托单位:
The Cichlid Dentition Integrates Tooth Number and Tooth Shape
-
批准号:7267992
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项目类别:
-
资助金额:$17.96万
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财政年份:2006
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负责人:Jeffery Todd Streelman
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依托单位:
Molecular Dissection of Tooth Shape
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批准号:6549343
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项目类别:
-
资助金额:$7.26万
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财政年份:2002
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负责人:Jeffery Todd Streelman
-
依托单位:
Molecular Dissection of Tooth Shape
-
批准号:6648455
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项目类别:
-
资助金额:$6.37万
-
财政年份:2002
-
负责人:Jeffery Todd Streelman
-
依托单位:
Molecular Dissection of Tooth Shape
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批准号:6986692
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项目类别:
-
资助金额:$0.93万
-
财政年份:2002
-
负责人:Jeffery Todd Streelman
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依托单位:
海外基金