Fully Automated Motion-corrected MR Spectroscopy in Human Brain and Spinal Cord

项目总结/摘要 质子磁共振波谱（1H MRS）和波谱成像（MRSI）允许无创研究 大脑化学然而，主体运动仍然是MRS中的主要障碍，特别是在运动倾向中。 人群，如儿童、老年人和运动障碍患者。运动导致不准确 局部化并降低MRS频谱质量。这些影响大多无法追溯纠正， 必须前瞻性地（即实时地）校正。在大脑中，现有的前瞻性运动校正MRS 序列目前仅限于少数研究中心并且没有被广泛使用。在脊髓中， 尚未报道预期的运动和匀场校正。本申请的主要目的是 为大脑和脊髓开发全自动、高性能、运动校正的MRS序列， 也易于与其他机构共享（无需额外的外部硬件），并且易于使用。我们 具体目标如下。在目标1A中，我们将开发更快、更少的改进型大脑导航仪， 对B 0不均匀性的灵敏度，并将允许在3 T和7 T下调整MRS体素中的二阶导数。在 目的1B，我们将在3 T和7 T下开发脊髓的前瞻性运动矫正。在目标2中，我们将充分 自动化序列工作流程，以允许“按钮式”采集可再现的高质量MRS数据，甚至 非MRS专家在目标3中，我们将评估目标1和目标2中开发的技术在真实的环境中的性能。 健康志愿者（儿童、年轻人和老年人）和患有 I型粘多糖样变性、肾上腺脑白质营养不良和弗里德赖希共济失调。我们将首先开发这些新的 西门子扫描仪上的技术，目标是在下一笔资金中将其翻译给其他制造商 期我们期望“按钮式”数据采集与前瞻性运动校正一起将消除 仍然存在获取具有一致高质量的MRS数据的障碍。既提高了光谱质量， 作为一个整体，减少频谱质量的变化是可靠的MRS测量的关键。与 随着可靠性和易用性的提高，脑和脊髓MRS的全部潜力将广泛用于 即将进行的临床研究和基因治疗试验。

PROJECT SUMMARY/ABSTRACT Proton magnetic resonance spectroscopy (1H MRS) and spectroscopic imaging (MRSI) allow noninvasive study of brain chemistry. However, subject motion remains a major obstacle in MRS, especially in motion-prone populations such as children, the elderly, and patients with movement disorders. Motion results in inaccurate localization and degrades MRS spectral quality. Most of these effects cannot be corrected retroactively, and must be corrected prospectively (i.e. in real-time). In the brain, existing prospective motion-corrected MRS sequences are currently limited to a handful of research centers and are not widely used. In the spinal cord, prospective motion and shim correction has not been reported. The main objective of this application is to develop fully automated, high performance, motion-corrected MRS sequences for the brain and spinal cord, that are also easy to share (no additional external hardware needed) with other institutions and easy to use. Our specific aims are as follows. In Aim 1A, we will develop improved brain navigators that are faster and less sensitivity to B0 inhomogeneities, and will allow adjustment of 2nd order shims in the MRS voxel at 3T and 7T. In Aim 1B, we will develop prospective motion correction in the spinal cord at 3T and 7T. In Aim 2, we will fully automate the sequence workflow to allow “push-button” acquisition of reproducible, high quality MRS data, even by non-MRS experts. In Aim 3, we will assess the performance of techniques developed in Aims 1 and 2 in real- life conditions in healthy volunteers (children, young and elderly adults) and in children with mucopolysaccharidosis type I, adrenoleukodystrophy and Friedreich ataxia. We will initially develop these new techniques on Siemens scanners, with the goal of translating them to other manufacturers in the next funding period. We expect that “push-button” data acquisition together with prospective motion correction will remove remaining obstacles for acquisition of MRS data with consistently high quality. Both improving spectral quality as a whole and decreasing the variability in spectral quality are key for reliable MRS measurements. With improved reliability and ease of use, the full potential of brain and spinal cord MRS will be widely available for upcoming clinical studies and gene therapy trials.