Characterization of amygdalar circuits mediating suppression of innate social behaviors

摘要 在先天行为中，交配和攻击行为被称为社会行为 是由另一个社会个体引发并指向另一个社会个体的。天生的社会行为，如交配 和攻击性是由辅助嗅觉回路驱动的。这两 行为需要严格监管，以防止不良社会条件下不适当的社会交往。 条件（例如，在生病的女性或捕食者的存在）。虽然以前的研究大多 专注于阐明驱动先天社会行为的神经通路，神经回路和 在不适当的条件下抑制这些行为的机制很差， 明白作为初步结果，我们能够表明，大脑皮层杏仁核的激活 后内侧（CoApm），辅助嗅觉信息的主要接受者，抑制 男性生殖行为与这种抑制功能一致，CoApm活性是 被已知会抑制这些社会行为的病态同种所增强。我们一起， 初步结果表明，CoApm可能参与抑制先天社会性 在不利条件下的行为。我们将通过询问1）CoApm是否 需要抑制雄性对患病雌性的生殖行为，2）如果CoApm介导了这一点， CoApm是否通过传入内侧杏仁核（MeA）发挥作用 投射是受调节的促甲状腺激素释放激素（TRH）。

ABSTRACT Of the innate behaviors, mating and aggression are termed as social for these behaviors are elicited by and directed at another social individual. Innate social behaviors, such as mating and aggression, in rodents are driven by the accessory olfactory circuits. Both of these behaviors need to be tightly regulated to prevent inappropriate social interactions under adverse condition (e.g. in the presence of sick females or predators). While previous studies have mostly focused on elucidating neural pathways driving innate social behaviors, neural circuits and mechanism, by which these behaviors are suppressed under inappropriate conditions are poorly understood. As preliminary results, we are able to show that activation of cortical amygdala posterior medial (CoApm), the major recipient of accessory olfactory information, suppresses male reproductive behaviors. Consistent with this inhibitory function, CoApm activity was enhanced by sick conspecifics that are known to inhibit these social behaviors. Together, our preliminary results suggest that the CoApm might be involved in inhibiting innate social behaviors under unfavorable conditions. We will test this hypothesis by asking 1) if CoApm is required to inhibit male reproductive behavior toward sick females, 2) if CoApm mediates this function via its efferents to medial amygdala (MeA), and 3) whether the CoApm to MeA projection is modulated thyrotropin-releasing hormone (TRH).