Characterization of amygdalar circuits mediating suppression of innate social behaviors

摘要 在先天行为中，交配和攻击被称为这些行为的社会性 被另一个社会个体引诱并指向另一个社会个体。先天的社会行为，如交配 而啮齿动物的攻击性是由辅助嗅觉回路驱动的。这两个都是 需要严格监管行为，以防止在不利的情况下进行不适当的社交 条件(例如，当有患病的雌性或捕食者在场时)。虽然之前的研究大多是 重点阐述了驱动先天社会行为的神经通路、神经回路和 在不适当的条件下抑制这些行为的机制很差 明白了。作为初步结果，我们能够证明杏仁皮质的激活 辅助嗅觉信息的主要接受者--后内侧核(CoApm)抑制 男性生殖行为。与这种抑制功能相一致，CoApm的活性是 通过已知的抑制这些社会行为的病态同种物质来增强。在一起，我们的 初步结果表明，CoApm可能参与了抑制先天社交 在不利条件下的行为。我们将通过询问1)CoApm是否 需要抑制男性对患病女性的生殖行为，2)如果CoApm介导这一点 通过其向杏仁内侧核(Mea)的传出发挥作用；3)CoApm是否对mea起作用。 投射是调节性促甲状腺激素释放激素(TRH)。

ABSTRACT Of the innate behaviors, mating and aggression are termed as social for these behaviors are elicited by and directed at another social individual. Innate social behaviors, such as mating and aggression, in rodents are driven by the accessory olfactory circuits. Both of these behaviors need to be tightly regulated to prevent inappropriate social interactions under adverse condition (e.g. in the presence of sick females or predators). While previous studies have mostly focused on elucidating neural pathways driving innate social behaviors, neural circuits and mechanism, by which these behaviors are suppressed under inappropriate conditions are poorly understood. As preliminary results, we are able to show that activation of cortical amygdala posterior medial (CoApm), the major recipient of accessory olfactory information, suppresses male reproductive behaviors. Consistent with this inhibitory function, CoApm activity was enhanced by sick conspecifics that are known to inhibit these social behaviors. Together, our preliminary results suggest that the CoApm might be involved in inhibiting innate social behaviors under unfavorable conditions. We will test this hypothesis by asking 1) if CoApm is required to inhibit male reproductive behavior toward sick females, 2) if CoApm mediates this function via its efferents to medial amygdala (MeA), and 3) whether the CoApm to MeA projection is modulated thyrotropin-releasing hormone (TRH).