Characterization of amygdalar circuits mediating suppression of innate social behaviors

杏仁核回路介导先天社会行为抑制的特征

• 批准号: 10015343
• 负责人: Gloria Choi
• 金额: $ 58.85万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10015343
• 关键词: Aggressive behavior; Amygdaloid structure; Anatomy; Automobile Driving; Behavior; Brain; Detection; Female; Glutamates; Individual; Instinct; Lead; Medial; Mediating; Neural Pathways; Neuromodulator; Neurons; Olfactory Pathways; Partner in relationship; Peptides; Pheromone; Play; Population; Process; Reproductive Behavior; Rodent; Role; Signal Transduction; Social Behavior; Social Behavior Disorders; Social Interaction; Stimulus; Symptoms; Syndrome; Testing; Thyrotropin-Releasing Hormone; hormonal signals; insight; interdisciplinary approach; male; neural circuit; neuromechanism; prevent; receptor expression; sensory stimulus; social; social anxiety

ABSTRACT Of the innate behaviors, mating and aggression are termed as social for these behaviors are elicited by and directed at another social individual. Innate social behaviors, such as mating and aggression, in rodents are driven by the accessory olfactory circuits. Both of these behaviors need to be tightly regulated to prevent inappropriate social interactions under adverse condition (e.g. in the presence of sick females or predators). While previous studies have mostly focused on elucidating neural pathways driving innate social behaviors, neural circuits and mechanism, by which these behaviors are suppressed under inappropriate conditions are poorly understood. As preliminary results, we are able to show that activation of cortical amygdala posterior medial (CoApm), the major recipient of accessory olfactory information, suppresses male reproductive behaviors. Consistent with this inhibitory function, CoApm activity was enhanced by sick conspecifics that are known to inhibit these social behaviors. Together, our preliminary results suggest that the CoApm might be involved in inhibiting innate social behaviors under unfavorable conditions. We will test this hypothesis by asking 1) if CoApm is required to inhibit male reproductive behavior toward sick females, 2) if CoApm mediates this function via its efferents to medial amygdala (MeA), and 3) whether the CoApm to MeA projection is modulated thyrotropin-releasing hormone (TRH).

抽象的 在先天行为中，交配和攻击被称为这些行为的社会行为 由另一个社会个体引起并针对另一个社会个体。天生的社会行为，例如交配 啮齿类动物的攻击性和攻击性是由附属嗅觉回路驱动的。这两个 需要严格规范行为，以防止不利的情况下不适当的社交互动 状况（例如，有生病的雌性或掠食者在场）。虽然之前的研究大多 专注于阐明驱动先天社会行为、神经回路和 在不适当的条件下抑制这些行为的机制很差 明白了。作为初步结果，我们能够表明皮质杏仁核的激活 后内侧（CoApm）是辅助嗅觉信息的主要接收者，抑制 男性的生殖行为。与这种抑制功能一致，CoApm 活性为 已知会抑制这些社会行为的患病同种人会增强这种能力。在一起，我们的 初步结果表明 CoApm 可能参与抑制先天社交 不利条件下的行为。我们将通过询问 1) CoApm 是否是来检验这个假设 需要抑制雄性对患病雌性的生殖行为，2）如果 CoApm 介导这一点 通过其传出神经至内侧杏仁核 (MeA) 发挥功能，以及 3) CoApm 是否至 MeA 预测是调节促甲状腺素释放激素（TRH）。