Understanding the effects of listening effort on sentence processing and memory in sensorineural hearing loss: Evidence from simultaneous electrophysiology and pupillometry

了解听力努力对感音神经性听力损失的句子处理和记忆的影响：来自同步电生理学和瞳孔测量的证据

• 批准号: 10360755
• 负责人: Brennan Payne
• 金额: $ 15.25万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360755
• 关键词: Acoustics; Address; Adopted; Adult; Affect; Age; Aging; Area; Attention; Audiology; Award; Brain; Chronic; Clinical; Clinical assessments; Cognitive; Comprehension; Data; Dementia; Development; Elderly; Electrophysiology (science); Event; Evidence based intervention; Extramural Activities; Foundations; Funding; Future; Goals; Health; Impairment; Intervention; Knowledge; Language; Literature; Measures; Memory; Methods; Mydriasis; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Noise; Performance; Physiological; Prevalence; Process; Psycholinguistics; Public Health; Quality of life; Research; Research Priority; Resources; Retrieval; Risk; Semantics; Sensorineural Hearing Loss; Social isolation; Speech; Speech Perception; Testing; Time; Voice; Work; age related; base; career; clear speech; clinically relevant; cognitive neuroscience; cost; design; evidence base; experience; experimental study; hearing impairment; improved; innovation; insight; language processing; memory process; neuromechanism; novel; relating to nervous system; response; specific language impairment; speech in noise; speech processing; syntax

PROJECT SUMMARY / ABSTRACT Sensorineural hearing loss (SNHL) is among the most prevalent chronic conditions in aging and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased risk for the development of dementia in older adulthood. Typical audiological tests and interventions, which focus on measuring and restoring audibility, do not explain the full range of cognitive difficulties that adults with hearing loss experience in speech comprehension. For example, adults with SNHL have to work disproportionally harder to decode acoustically degraded speech. That additional effort is thought to diminish shared executive and attentional resources for higher-level language processes, impacting subsequent comprehension and memory, even when speech is completely intelligible. This phenomenon has been referred to as listening effort (LE). There is a growing understanding that these cognitive factors are a critical and often “hidden effect” of hearing loss. At the same time, the effects of LE on the neural mechanisms of language processing and memory in SNHL are currently not well understood. In order to develop evidence- based assessments and interventions to improve comprehension and memory in SNHL, it is critical that we elucidate the cognitive and neural mechanisms of LE and its consequences for speech comprehension. In this project, we adopt a multi-method approach, combining methods from clinical audiology, psycholinguistics, and cognitive neuroscience to address this gap of knowledge. Specifically, we adopt a novel and innovative method of co-registering pupillometry (a reliable physiological measure of LE) and language-related event-related brain potential (ERP) measures during real-time speech processing to characterize the effects of acoustic challenge and LE on high-level language processes (e.g., semantic retrieval, syntactic integration) and subsequent speech memory in older adults with SNHL. This innovative work addresses a time-sensitive gap in the literature regarding the identification of objective and reliable markers of specific neurocognitive processes impacted by acoustic challenge and LE in age-related SNHL.

项目概要/摘要 感音神经性听力损失 (SNHL) 是衰老过程中最常见的慢性疾病之一， 对言语理解产生深远的负面影响，导致社会孤立感增加，语言质量下降 生活，并增加老年痴呆症的风险。典型的听力学测试和 干预措施的重点是测量和恢复听力，并不能解释认知的全部范围 患有听力损失的成年人在言语理解方面遇到的困难。例如，患有 SNHL 的成年人 必须付出不成比例的努力来解码声学退化的语音。额外的努力被认为 减少高级语言过程的共享执行和注意力资源，影响 随后的理解和记忆，即使言语是完全可理解的。这种现象有 被称为倾听努力（LE）。人们越来越认识到这些认知因素是 听力损失的严重且往往是“隐藏的影响”。同时，LE对神经机制的影响 SNHL 中语言处理和记忆的机制目前尚不清楚。为了开发证据—— 基于评估和干预措施来提高 SNHL 的理解力和记忆力，至关重要的是，我们 阐明 LE 的认知和神经机制及其对言语理解的影响。在这个 项目中，我们采用了多种方法，结合了临床听力学、心理语言学和 认知神经科学旨在解决这一知识差距。具体来说，我们采用了新颖且创新的方法 共同记录瞳孔测量（LE 的可靠生理测量）和语言相关事件相关大脑 实时语音处理期间的潜在（ERP）测量来表征声学挑战的影响 和 LE 高级语言处理（例如语义检索、句法整合）和后续 患有 SNHL 的老年人的言语记忆。这项创新工作解决了时间敏感的差距 关于识别特定神经认知过程的客观可靠标记的文献 受到与年龄相关的 SNHL 中声学挑战和 LE 的影响。