Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A Longitudinal Study

年轻癌症幸存者的社会健康、活动行为和生活质量：一项纵向研究

• 批准号: 10361472
• 负责人: Kimberly Ann Miller
• 金额: $ 66.58万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10361472
• 关键词: Accelerometer; Adolescent and Young Adult; Aftercare; Age; Behavior; Breast Melanoma; Cancer Patient; Cancer Survivor; Characteristics; Childhood; Chronic; Clinical; Complex; Comprehensive Cancer Center; Cross-Sectional Studies; Development; Diagnosis; Disease; Disease-Free Survival; Emotional; Employment; Ethnic Origin; Fostering; Gender; General Population; Health; Health Promotion; Health Status; Hospitals; Impairment; Intervention; Latino; Lead; Life; Life Experience; Link; Longitudinal Studies; Los Angeles; Malignant Neoplasms; Measures; Medical; Outcome; Patients; Physical Function; Physical activity; Population; Populations at Risk; Process; Prospective Studies; Quality of life; Questionnaires; Race; Recovery; Reporting; Research; Risk Behaviors; Risk Factors; Social Functioning; Social Network; Social support; Socioeconomic Status; Structure; Symptoms; Testing; Testis; Thyroid Gland; Time; Treatment-related toxicity; Vulnerable Populations; Well in self; Wrist; actigraphy; cancer diagnosis; cancer therapy; cohort; effective intervention; ethnic diversity; experience; follow-up; high risk; improved; longitudinal design; mortality; patient oriented; peer; prospective; recruit; safety net; sedentary; sex; social; social contact; social relationships; sociodemographics; survivorship; treatment effect; young adult; young cancer survivor

Abstract Approximately 70,000 adolescents and young adults are diagnosed with cancer between the ages of 15-39 in the U.S. every year. Due to their age and life stage, the experience of a cancer diagnosis as a young adult (YA) can lead to a cascade of emotional and physical challenges. A key obstacle faced by YA cancer patients is impaired social health, a complex construct that includes perceived social belonging, social support, and social network composition. YA patients report social health challenges such as maintaining existing and forming new social relationships after diagnosis, which may contribute to poor quality of life post-cancer. Diminished social health is a major risk factor for poorer health in the general population and has been found to reduce health-promoting behaviors such as physical activity, in part because of the lack of healthy opportunities and support that social contacts can provide. Cancer patients clearly benefit from greater levels of physical activity and lower levels of sedentary time as these are associated with improved quality of life, longer periods of disease-free survival, and lower mortality. Thus, understanding the relationships between social health, physical activity, and quality of life is critically important for YA cancer patients, as the impaired social health experienced by these patients may reduce their activity levels and endanger long-term health outcomes. The overall hypothesis is that social health in YA is negatively impacted following a cancer diagnosis, and that detriments in social health influence subsequent physical activity behaviors and survivorship quality of life (emotional well-being and physical function). In the proposed study, we will comprehensively prospectively assess social health over 12 months and examine its influence on activity behaviors and quality of life. Assessment will begin proximal to diagnosis when changes in social health are likely to initiate for YA cancer patients, with subsequent follow-ups at 3, 6, and 12 months. This longitudinal design will enable the examination of the dynamic changes in social health during and after therapy and its predictive influence on physical activity and quality of life. The Specific Aims are: Aim 1: we will characterize the trajectories of social health in YA cancer patients and assess their influences on quality of life in survivorship; Aim 2: we will investigate the longitudinal associations between social health and activity behaviors in YA cancer patients and test the mediational and reciprocal relationships between social health, activity behaviors, and quality of life; Aim 3: we will explore demographic and clinical moderators of the relationships between social health, activity behaviors, and quality of life. Understanding the mechanistic processes by which social health impacts activity behaviors and quality of life will inform the development of effective intervention strategies to foster social health and improve healthy survivorship for this at-risk and vulnerable population.

摘要 在美国，大约有70，000名15-39岁的青少年和年轻人被诊断患有癌症。 美国每年。由于他们的年龄和生活阶段，作为一个年轻的成年人诊断癌症的经验， (YA)会带来一连串的情绪和身体上的挑战YA癌症患者面临的一个关键障碍 是受损的社会健康，一个复杂的结构，包括感知的社会归属感，社会支持， 社会网络构成。YA患者报告了社会健康挑战，例如维持现有的 诊断后形成新的社会关系，这可能导致癌症后生活质量低下。 社会健康状况下降是普通人群健康状况较差的一个主要风险因素， 减少促进健康的行为，如体育活动，部分原因是缺乏健康的 社会关系所能提供的机会和支持。癌症患者明显受益于更高的水平 体育活动和较低水平的久坐时间，因为这些都与提高生活质量， 更长的无病生存期和更低的死亡率。因此，了解 社会健康、身体活动和生活质量对YA癌症患者至关重要，因为 这些患者经历的社会健康可能会降低他们的活动水平，并危及长期健康 结果。总体假设是，癌症后，YA的社会健康受到负面影响 诊断，以及社会健康的改善影响随后的身体活动行为， 生存生活质量（情感健康和身体功能）。在拟议的研究中，我们将 全面前瞻性评估12个月的社会健康状况，并检查其对活动的影响 行为和生活质量。评估将在接近诊断时开始，当社会健康的变化是 可能在YA癌症患者中启动，随后在3个月、6个月和12个月进行随访。该纵向 设计将能够检查治疗期间和治疗后社会健康的动态变化， 对身体活动和生活质量的预测性影响。具体目标是：目标1：我们将 YA癌症患者的社会健康轨迹并评估其对生活质量的影响 目标2：我们将调查社会健康和活动之间的纵向联系 YA癌症患者的行为，并测试社会健康， 活动行为和生活质量;目标3：我们将探索人口统计学和临床调节因素， 社会健康、活动行为和生活质量之间的关系。理解机械 社会健康影响活动行为和生活质量的过程将告知发展 有效的干预战略，以促进社会健康和改善健康的生存，这在风险和 弱势群体。