Research Infrastructure Core

研究基础设施核心 摘要 前列腺癌是美国男性癌症死亡的第二大原因，仅次于肺癌。在……里面 非洲裔美国男性，前列腺癌发病率高65%，死亡率高于 是高加索男性的两倍。年发病率和死亡率出现种族差异的原因 人们对非裔美国人的了解很少，但可能涉及生物和环境因素。这个 克拉克亚特兰大大学(CAU)癌症研究和治疗发展中心(CCRTD)是 致力于以持续的方式加强全面的研究计划，以调查 细胞和遗传因素通过三个途径参与前列腺癌的发生、发展和转移 目前提案中提出的研究和试点项目。为了支持研究和试点项目， 研究基础设施核心将用最先进的仪器支持五个功能核心实验室 以及相关服务。此外，还将创建一个动物核心实验室，为项目负责人提供当地的 优质的动物护理和先进的动物研究。最后，将加强培训，以确保 项目负责人和其他用户熟悉核心设备的应用。总而言之， 研究基础设施核心将是研究和试点项目以及 更大的研究社区，提供最先进的仪器设备，并确保拟议的 研究。

Research Infrastructure Core Abstract Prostate cancer is the second leading cause of cancer deaths among American men after lung cancer. In African-American men, the incidence of prostate cancer is 65% higher and the mortality rate is more than double compared to Caucasian men. The reasons for this racial disparity in incidence and death rate in African-Americans are poorly understood, but may involve both biological and environmental factors. The Center for Cancer Research and Therapeutic Development (CCRTD) at Clark Atlanta University (CAU) is committed to an on-going approach to enhance the comprehensive research program to investigate the cellular and genetic factors involved in initiation, progression and metastasis of prostate cancer through three research and pilot projects proposed in the current proposal. In order to support the research and pilot projects, the Research Infrastructure Core will support five functional Core Laboratories with state-of-the-art instruments and related services. Moreover, an Animal Core Laboratory will be created to provide project leaders with local quality animal care and advance animal research. Lastly, enhanced training will be provided to ensure that project leaders and other users are acquainted with the application of core equipment. In conclusion, the Research Infrastructure Core will be an invaluable resource to the research and pilot projects, as well as the larger research community, to provide state-of-the-art instrumentation, and ensure the success of the proposed research.