Pilot Projects Core

项目摘要：试点项目核心 拟议中的NIDA成瘾神经电路中心的主要目标是扩展和增强 美国国立卫生研究院资助的明尼苏达大学(UMN)成瘾研究项目的研究能力。这个 建议的病毒创新核心(VIC)、行为过程中的成像细胞核心(ICBC)、结构电路核心 (SCC)和成瘾连接核心(ACC)将提供广泛的技术专长和基础设施，以 个人调查员。为补充这些努力，试点项目核心将提供必要的 通过选择和资助创新项目来促进新的研究和互动的手段 协同结合研究核心的能力，推动神经电路研究的极限。 由中心主任托马斯博士领导的PPC将聘请一个由中心教职员工和外部顾问组成的小组 (即试点小组)谁将审查提案并将最终入围者提交给指导委员会进行最终决定 决心。在与NIDA的计划工作人员协商后，每个项目将获得两到四个项目的资助 财政年度。提案将根据标准的NIH审查标准进行审查(意义， 创新、严谨和可行性)，并应处理以下一项或多项优先事项：1)Esis；2)新的 参与成瘾研究的人；3)展示翻译潜力；4)聘请一组没有 以前相互协作；5)以新颖的方式使用研究核心；和/或6)开发实质性的 一个或多个研究核心的新功能。不需要包括初步数据。应用 对于“过渡性资金”或延长正在进行的项目，将不受欢迎。最后，试点小组也将开展工作 关于研究传播，使中心成员有机会定期看到具体的 研究核心功能的应用，我们预计这将刺激这些功能的创造性新用途 和新的合作。 核心有两个具体目标：目标1将与前两个获奖者建立试点研究计划 团队。其中包括新调查者帕特里克·罗斯韦尔博士和埃丝特·克鲁克-马格努森博士的一个项目 题为《解析伏隔核神经元间多样性以了解芬太尼的作用》和 由马修·查菲博士、本杰明·海登博士和简·齐默尔南博士共同完成的题为《前顶叶环路》的项目 猕猴的操控。“他们的团队由一名ESI(齐默尔曼)和两名老牌调查人员组成， 组建一个新的协作团队。拟议的奖励金额为5万美元，最长可达两年。在目标2中， 试点小组将与指导委员会协商，建立和维护基础设施、政策和 创新试点项目的奖项选择、持续评估和研究传播的程序。

PROJECT SUMMARY: Pilot Projects Core The primary goal of the proposed NIDA Center for Neural Circuits in Addiction is to extend and enhance the research capabilities of NIH-funded addiction research projects at the University of Minnesota (UMN). The proposed Viral Innovation Core (VIC), Imaging Cells during Behavior Core (ICBC), Structural Circuits Core (SCC) and Addiction Connectome Core (ACC) will provide extensive technical expertise and infrastructure to individual investigators. To complement these efforts, the Pilot Project Core (PPC) will provide necessary means to foster new research and interactions by selecting and funding innovative projects that can synergistically combine the capabilities of the Research Cores to push the envelope in neural circuit research. The PPC, led by Center Director, Dr. Thomas, will engage a panel of Center faculty and External Advisors (i.e. the Pilot Panel) who will review proposals and present finalists to the Steering Committee for final determination. Following consultation with Program staff at NIDA, two to four projects will be funded each fiscal year. Proposals will be reviewed in accordance with standard NIH review criteria (significance, innovation, rigor and feasibility) and should address one or more of the following priorities: 1) ESIs; 2) New entrants to addiction research; 3) Demonstrate translational potential; 4) Engage a team of PIs who have not previously collaborated with one another; 5) Use Research Cores in a novel way; and/or 6) Develop substantial new capabilities for one or more Research Cores. Inclusion of preliminary data is not required. Applications for "bridge funds" or to extend ongoing projects will not be entertained. Finally, the Pilot Panel will also work on research dissemination so that Center members have the opportunity on a regular basis to see specific applications of Research Core functions, which we expect will stimulate creative new uses for these functions and new collaborations. The Core has two Specific Aims: Aim 1 will establish the Pilot Research Program with the first two recipient teams. These include a project from New Investigators, Drs. Patrick Rothwell and Esther Krook-Magnuson entitled: “Parsing Interneuron Diversity in the Nucleus Accumbens to Understand the Actions of Fentanyl” and a project from Drs. Matthew Chafee, Benjamin Hayden, and Jan Zimmernann titled “Front-Parietal Circuit Manipulation in Macaques.” Their team is composed of an ESI (Zimmermann) and two established investigators, forming a new collaborative team. Proposed awards are $50k over a period of up to two years. In Aim 2, the Pilot Panel, in consultation with the Steering Committee, will establish and maintain infrastructure, policies and procedures for award selection, ongoing evaluation and research dissemination of innovative pilot projects.