Training in Translating Neuroscience to Therapies

将神经科学转化为治疗的培训

• 批准号: 10204266
• 负责人: M. Maral Mouradian
• 金额: $ 19.8万
• 依托单位: RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10204266
• 关键词: Neurosciences; Training; Translating

Project Summary This is a new program for “Training in Translating Neuroscience to Therapies” at Rutgers University. Its overall objective is to provide scientists in training performing laboratory-based experiments the skills and competencies needed to advance their discoveries to treatments for neurological disorders. The aims of the program are to: 1) provide a continuum of comprehensive training that advances translational neuroscience research towards therapeutic developments; 2) expand the pipeline of translational neuroscience researchers within a diverse cohort of trainees; and 3) leverage Rutgers’ strengths in neuroscience drug discovery and development to provide broad experiences to trainees in this program. The rationale for establishing this program is the increasing burden of neurological diseases globally, many of which have no good treatments much less cures, and the accelerated advances in scientific discoveries in the genetics and molecular pathogenesis of nervous system disorders. Thus, this is an opportune time to harness knowledge gained in our understanding of disease processes, fill in the gaps in this knowledge base, and translate basic discoveries to deliverables for patients suffering from these disorders. The design of the training program combines traditional coursework, seminars, conferences, a biostatistics curriculum, and an annual retreat, along with experiential learning through a series of apprenticeships with experts in fields that link scientific innovation with industry to advance laboratory discoveries to clinical trials. Trainees will learn from neurologists and trialists, and actively engage in clinical trials. The training period for each participant is two years. A total of two positions are requested in year one, and four positions in subsequent years. The trainees will include senior graduate students, MD/PhD students and postdoctoral fellows at a ratio of 1:1:2. Trainees will work in the laboratories of highly qualified neuroscientists and translational investigators employing multidisciplinary approaches to learn the principles of rigorous and reproducible research. They will also have mentors with expertise in medicinal chemistry, drug discovery and development, clinical research and trials, start-ups, and career opportunities. Faculty and trainees will benefit from a formal mentoring program in place at Rutgers Biomedical and Health Sciences. Program oversight includes internal and external advisory boards, and an Executive Committee consisting of senior leadership at Rutgers University with extensive experience in translational and clinical research, pharmaceutical development, commercialization of innovations, and graduate and postgraduate education. The quality and effectiveness of the training program will be assessed by an independent assessor. The intended outcome of this program is to train the next generation of leaders in translational neuroscience who have the knowhow and passion to take basic discoveries to clinical trials and treatments that benefit millions with neurological diseases.

项目摘要 这是罗格斯大学的一个新项目，“将神经科学转化为治疗方法的培训”。其整体 目标是提供科学家在培训中进行实验室实验的技能和能力 需要将他们的发现推进到神经系统疾病的治疗上。该方案的目标是：1） 提供一个连续的综合培训，推动转化神经科学研究， 治疗的发展; 2）扩大管道的翻译神经科学研究人员在一个多样化的 学员队列; 3）利用罗格斯大学在神经科学药物发现和开发方面的优势， 为该计划的学员提供广泛的经验。建立这一方案的理由是， 全球神经系统疾病的负担日益增加，其中许多疾病没有良好的治疗方法，更不用说治愈了， 以及神经系统疾病的遗传学和分子发病机制方面的科学发现的加速进展， 系统紊乱因此，这是一个利用我们在理解疾病中获得的知识的适当时机 过程，填补知识库的空白，并将基本发现转化为患者的可交付成果 患有这些疾病。培训计划的设计结合了传统的课程，研讨会， 会议，生物统计学课程，以及年度务虚会，沿着通过一系列的体验式学习 在将科学创新与工业联系起来的领域， 临床试验的发现。学员将向神经科医生和试验者学习，并积极参与临床 审判每名学员的培训期为两年。第一年共要求两个职位， 在随后的几年里，四个职位。学员将包括高年级研究生、医学博士/博士生 博士后比例为1：1：2。学员将在高素质的神经科学家的实验室工作 和翻译研究人员采用多学科的方法来学习严格的原则， 可复制的研究他们还将有具有药物化学，药物发现和 开发、临床研究和试验、初创企业和职业机会。教师和学员将受益 来自罗格斯大学生物医学与健康科学学院的一个正式的指导项目。项目监管 包括内部和外部咨询委员会，以及由高级领导组成的执行委员会， 罗格斯大学在转化和临床研究，药物开发， 创新的商业化，以及研究生和研究生教育。质量和效益 培训计划将由独立评审员评审。该计划的预期成果是 培养下一代的领导者在转化神经科学谁有知识和激情采取 临床试验和治疗的基本发现，使数百万神经系统疾病患者受益。