Integrated Technologies

综合技术

• 批准号: 10205110
• 负责人: Martin Fuchs
• 金额: $ 103.43万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205110
• 关键词: Adopted; Authorization documentation; Award; Biological; Biological Sciences; Collaborations; Communication; Communities; Computer Systems; Computer software; Crystallography; Data Analyses; Databases; Department of Energy; Development; Discipline; Engineering; Ensure; Equipment Failure; Evaluation; Evolution; Expenditure; Fostering; Funding; Goals; Grant; Human Resources; Image; Infrastructure; Investments; Knowledge; Laboratories; Libraries; Light; Maintenance; Methods; Mind; Minor; Optics; Performance; Photons; Play; Resolution; Resource Sharing; Resources; Rest; Roentgen Rays; Role; Safety; Science; Source; Standardization; Structure; Synchrotrons; System; Techniques; Technology; United States National Institutes of Health; Work; X ray diffraction analysis; beamline; bioimaging; computational platform; computerized data processing; computing resources; cost effective; data handling; data management; density; design; experimental study; flexibility; frontier; improved; instrument; instrumentation; multimodality; operation; programs; repaired; software development; structural biology; tool; user-friendly

Abstract - Integrated Technologies Core The overall goal of the Integrated Technologies Core (ITC) is to provide coordinated access and cost-effective support for our facility – the Center for Biomolecular Structure (CBMS). The first role of the ITC within the CBMS is to enable technical and engineering support for two of the three scientific technical cores; these two cores are the ones that depend on hard-x-ray diffraction, two Macromolecular Crystallography (MX) beamlines: Frontier Microfocus Macromolecular Crystallography (FMX), and Highly Automated Macromolecular Crystallography (AMX), and scattering: Life Science X-ray Scattering (LiX), in structural biological studies. Constructed predominantly with an award from the National Institutes of Health (NIH), these three beamlines support structural biology and other disciplines, and the funding in this grant will support their continued operation. The third technical core, the Imaging core, serves five beamlines built and operated mostly by the Department of Energy (DOE) Basic Energy Sciences (BES), for which the life-science studies that we will support on these beamlines represent a minor component of their entire programs. Therefore, the maintenance and upgrade role that the ITC plays for the MX and Scattering Cores will be played by existing BES-sponsored technical staff for the Bioimaging Core. The second function of the ITC is to coordinate standards for hardware, software, controls, and networking and computing systems. It also assures resource sharing among all scientific technical cores in CBMS and supports efficient communication with the National Synchrotron Light Source II (NSLS-II) beamlines and the technical and engineering groups. We believe that by organizing our technical staff to function across the three beamlines we will make better use of our resources. We estimate that our collaboration saves personnel resources equivalent to two to three FTE. By pooling spare parts, and assuming equipment failures to be random, for three beamlines the reduction in investment in spares amounts to approximately 40%. This will allow us to provide backup coverage and extra support among the three, to be consistent in instrument design, and to make efficient use of accepted facilities-maintenance standards. Numerous resources within the ITC exist also in the rest of the NSLS-II; for us to share and exchange knowledge and apparatus will cross-fertilize opportunities for all of us and foster greater efficiency.

抽象-集成技术核心 综合技术核心(国贸中心)的总体目标是提供协调一致的接入和具有成本效益的 为我们的设施-生物分子结构中心(CBMS)提供支持。 国贸中心在建立信任措施中的第一个作用是为三个中的两个提供技术和工程支持 科学技术核心；这两个核心是依赖硬x射线衍射的核心，两个 大分子结晶学(MX)光束线：前沿微焦点大分子结晶学 (FMX)和高度自动化的大分子结晶学(AMX)，以及散射：生命科学X射线 散射(LIX)，在结构生物学研究中。主要由来自 美国国立卫生研究院(NIH)，这三条光束线支持结构生物学和其他学科， 而这笔赠款中的资金将支持他们继续运营。第三个技术核心--成像 核心，主要由能源部(DOE)基本能源部建造和运营的五条光束线提供服务 科学(BES)，我们将在这些光束线上支持的生命科学研究是辅修课程 是他们整个程序的组成部分。因此，国贸中心在维护和升级方面所发挥的作用 MX和散射核心将由BES赞助的现有生物成像核心技术人员扮演。 ITC的第二个职能是协调硬件、软件、控制和网络的标准 和计算机系统。它还确保建立信任措施中所有科学技术核心之间的资源共享 支持与国家同步加速器光源II(NSLS-II)光束线和 技术和工程小组。 我们相信，通过组织我们的技术人员在三条光束线上工作，我们将会做得更好 利用我们的资源。我们估计，我们的协作节省了相当于两到三个人的人力资源 全时当量。通过汇集备件，并假设设备故障是随机的，对于三条光束线， 备件投资减少约40%。这将使我们能够提供后备 三者之间的覆盖和额外支持，以保持仪器设计的一致性，并使效率 认可设施的使用.维护标准国贸中心内的许多资源也存在于其他方面 NSLS-II；对于我们来说，分享和交流知识和仪器将为 并促进更高的效率。