Integrated Technologies

综合技术

• 批准号: 10460484
• 负责人: Martin Fuchs
• 金额: $ 103.31万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460484
• 关键词: Adopted; Authorization documentation; Award; Biological; Biological Sciences; Collaborations; Communication; Communities; Computer Systems; Computer software; Crystallography; Data Analyses; Databases; Department of Energy; Development; Discipline; Engineering; Ensure; Equipment Failure; Evaluation; Evolution; Expenditure; Fostering; Funding; Goals; Grant; Human Resources; Image; Infrastructure; Investments; Knowledge; Laboratories; Libraries; Light; Maintenance; Methods; Mind; Minor; Optics; Performance; Photons; Play; Resolution; Resource Sharing; Resources; Rest; Roentgen Rays; Role; Safety; Science; Source; Standardization; Structure; Synchrotrons; System; Techniques; Technology; United States National Institutes of Health; Work; X ray diffraction analysis; beamline; bioimaging; computational platform; computerized data processing; computing resources; cost effective; data handling; data management; density; design; experimental study; flexibility; frontier; improved; instrument; instrumentation; multimodality; operation; programs; repaired; software development; structural biology; tool; user-friendly

Abstract - Integrated Technologies Core The overall goal of the Integrated Technologies Core (ITC) is to provide coordinated access and cost-effective support for our facility – the Center for Biomolecular Structure (CBMS). The first role of the ITC within the CBMS is to enable technical and engineering support for two of the three scientific technical cores; these two cores are the ones that depend on hard-x-ray diffraction, two Macromolecular Crystallography (MX) beamlines: Frontier Microfocus Macromolecular Crystallography (FMX), and Highly Automated Macromolecular Crystallography (AMX), and scattering: Life Science X-ray Scattering (LiX), in structural biological studies. Constructed predominantly with an award from the National Institutes of Health (NIH), these three beamlines support structural biology and other disciplines, and the funding in this grant will support their continued operation. The third technical core, the Imaging core, serves five beamlines built and operated mostly by the Department of Energy (DOE) Basic Energy Sciences (BES), for which the life-science studies that we will support on these beamlines represent a minor component of their entire programs. Therefore, the maintenance and upgrade role that the ITC plays for the MX and Scattering Cores will be played by existing BES-sponsored technical staff for the Bioimaging Core. The second function of the ITC is to coordinate standards for hardware, software, controls, and networking and computing systems. It also assures resource sharing among all scientific technical cores in CBMS and supports efficient communication with the National Synchrotron Light Source II (NSLS-II) beamlines and the technical and engineering groups. We believe that by organizing our technical staff to function across the three beamlines we will make better use of our resources. We estimate that our collaboration saves personnel resources equivalent to two to three FTE. By pooling spare parts, and assuming equipment failures to be random, for three beamlines the reduction in investment in spares amounts to approximately 40%. This will allow us to provide backup coverage and extra support among the three, to be consistent in instrument design, and to make efficient use of accepted facilities-maintenance standards. Numerous resources within the ITC exist also in the rest of the NSLS-II; for us to share and exchange knowledge and apparatus will cross-fertilize opportunities for all of us and foster greater efficiency.

摘要-集成技术核心 综合技术核心（ITC）的总体目标是提供协调一致的访问和成本效益。 支持我们的设施-生物分子结构中心（CBMS）。 ITC在CBMS中的第一个作用是为三个中的两个提供技术和工程支持 科学技术核心;这两个核心是依靠硬X射线衍射，两个 大分子晶体学（MX）光束线：前沿微焦点大分子晶体学 (FMX)和高自动化大分子晶体学（AMX），以及散射：生命科学X射线 散射（LiX），结构生物学研究。主要是建造一个奖项， 美国国立卫生研究院（NIH），这三个光束线支持结构生物学和其他学科， 这笔拨款将支持它们继续运作。第三个技术核心，成像 核心，服务于五条光束线，主要由能源部（DOE）基本能源部建造和运营 我们将在这些光束线上支持的生命科学研究代表了一个次要的项目， 是他们整个计划的一部分。因此，国贸中心在维护和升级方面发挥的作用 MX和散射核心将由现有的BES赞助的生物成像核心技术人员进行。 ITC的第二个功能是协调硬件、软件、控制和网络的标准 和计算系统。它还保证了CBMS中所有科学技术核心之间的资源共享， 支持与国家同步加速器光源II（NSLS-II）光束线的高效通信， 技术和工程组。 我们相信，通过组织我们的技术人员在三条光束线上发挥作用， 使用我们的资源。我们估计，我们的合作节省的人力资源相当于两到三个 FTE。通过共用备件，并假设设备故障是随机的，对于三条光束线， 备件投资减少约40%。这样我们就可以提供支援 覆盖范围和额外的支持，在仪器设计中保持一致，并使效率 使用公认的设施维护标准。国际贸易中心内部的许多资源也存在于其他国家 我们分享和交流知识和仪器将交叉施肥的机会， 我们所有人，并促进更高的效率。