Influence of menopause on adipose tissue accumulation and function

更年期对脂肪组织积累和功能的影响

• 批准号: 10371466
• 负责人: Kara L. Marlatt
• 金额: $ 12.46万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2022-11-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10371466
• 关键词: Abdomen; Adipocytes; Adipose tissue; Affect; Behavioral; Cardiometabolic Disease; Clinical Research; Cross-Sectional Studies; DNA; Data; Deuterium; Deuterium Oxide; Development Plans; Disease; Educational workshop; Estradiol; Estrogens; Extracellular Matrix; Fibrosis; Funding; Gene Expression; Genes; Grant; Health; Human; Hypertrophy; Impairment; Inflammation; Intervention; Kinetics; Knowledge; Learning; Life; Lipids; Manuscripts; Mass Fragmentography; Measures; Menopause; Metabolic; Modeling; Molecular Profiling; Obesity; Ovariectomy; Pathway interactions; Pharmacology; Plague; Play; Postmenopause; Premenopause; Proteins; Quantitative Reverse Transcriptase PCR; RNA; Research; Risk; Role; Sampling; Scientist; Techniques; Tissue Banks; Tissue Expansion; Tissue Sample; Training; United States; United States National Institutes of Health; Western Blotting; Withdrawal; Woman; Women' s Health; Writing; abdominal fat; cardiometabolic risk; career; career development; design; experience; improved; in vivo; lipid biosynthesis; middle age; novel; pre-clinical; prevent; protein expression; skill acquisition; skills; subcutaneous; symposium; therapy design; transcriptome sequencing

PROJECT SUMMARY Menopause is associated with a decline in estradiol (E2) that coincides with a significant accumulation of abdominal adipose tissue (AT). Yet, little is known about whether the loss of estradiol alters depot-specific AT expansion and function in a manner that promotes abdominal adiposity. It is unknown whether the increased abdominal AT mass that accompanies menopause is due to increased adipogenesis or other mechanisms such as increased hypertrophy or altered lipid storage. Our studies of premenopausal versus estrogen-depleted, postmenopausal women will allow us to examine estrogen withdrawal as a mechanism for adipogenesis (Aim 1) and altered AT function (Aim 2) within the subcutaneous abdominal and femoral depots that has not been explored. Our overarching hypothesis is that E2 loss with menopause promotes abdominal adipogenesis and impair AT function. We would be the first to identify potential novel depot-specific AT pathways in estrogen- depleted, postmenopausal women to explain the accumulation in abdominal adiposity that occurs with menopause. Knowledge gained from our studies will allow us to design and implement more targeted approaches for intervention that prevent abdominal AT accumulation in women. The acquired skills and career development plan in this K01 proposal will allow me to emerge as an independent, NIH-funded scientist in women’s health research that integrates treatments to reduce abdominal adiposity and improve metabolic health in midlife women.

项目摘要 更年期与雌二醇（E2）的下降有关，该雌二醇与大量积累相吻合 腹部脂肪组织（AT）。然而，关于雌二醇的损失是否改变了特定的沉积物的损失，在 以促进腹部肥胖的方式扩展和功能。未知是否增加 涉及更年期的腹部质量是由于脂肪生成增加或其他机制所致 随着肥大或脂质储存的改变。我们对绝经前与雌激素的研究的研究， 绝经后妇女将使我们能够检查雌激素戒断作为脂肪形成的机制（AIM 1） 并在功能下（目标2）在腹部和股骨沉积物中发生变化（目标2） 探索。我们的总体假设是，更年期的E2损失促进了腹部脂肪形成 并在功能时损害。我们将是第一个在雌激素中识别潜在的新型沉积物特异性的人 耗尽的绝经后妇女解释了与 绝经。从我们的研究中获得的知识将使我们能够设计和实施更多针对性的 干预措施的方法，以防止妇女积聚腹部。获得的技能和职业 这项K01提案中的发展计划将使我成为一名独立的NIH资助科学家 妇女的健康研究，整合治疗以减少腹部肥胖并改善代谢健康 在中年妇女。

项目成果

NAMS 2021 Utian Translational Science SymposiumSeptember 2021, Washington, DCCharting the path to health in midlife and beyond: the biology and practice of wellness.

• DOI: 10.1097/gme.0000000000001995
• 发表时间: 2022-05-01
• 期刊: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
• 影响因子: 2.7
• 作者: Santoro, Nanette F.;Coons, Helen L.;El Khoudary, Samar R.;Epperson, C. Neill;Holt-Lunstad, Julianne;Joffe, Hadine;Lindsey, Sarah H.;Marlatt, Kara L.;Montella, Patti;Richard-Davis, Gloria;Rockette-Wagner, Bonny;Salive, Marcel E.;Stuenkel, Cynthia;Thurston, Rebecca C.;Woods, Nancy;Wyatt, Holly
• 通讯作者: Wyatt, Holly