Examining the Integrative Effects of Adolescent, Parent, Provider, and Practice Level Factors on Adolescents' HPV Vaccine Uptake across Six Asian American Subgroups

检查青少年、家长、提供者和实践水平因素对六个亚裔美国人亚群体青少年 HPV 疫苗接种的综合影响

• 批准号: 10371334
• 负责人: Lin Zhu
• 金额: $ 8.32万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10371334
• 关键词: 12 year old; 17 year old; 9 year old; Address; Adolescent; Advisory Committees; Affect; Age; Anogenital venereal warts; Asian; Asian Americans; Asian Indian; Awareness; Centers for Disease Control and Prevention (U.S.); Cervix Uteri; Cessation of life; Characteristics; Child; Chinese; Clinic; Clinical; Clinical Research; Complex; Data; Development; Disease; Eligibility Determination; Empirical Research; Equation; Ethnic Origin; Family Practice; Female Adolescents; Filipino; Goals; Gold; Health; Hospitals; Human Papilloma Virus Vaccination; Human Papilloma Virus Vaccine; Human Papillomavirus; Human papillomavirus 16; Human papillomavirus 18; Immunization; Individual; Japanese; Knowledge; Koreans; Link; Literature; Logistic Regressions; Malignant Neoplasms; Mediating; Mediator of activation protein; Modeling; National Cancer Institute; Oropharyngeal; Parents; Pediatrics; Persons; President' s Cancer Panel; Process; Provider; Public Health; Race; Recommendation; Reporting; Research; Role; Safety; Sampling; Sampling Studies; Services; Sexually Transmitted Diseases; Subgroup; Surveys; Teenagers; Translating; Vaccinated; Vaccination; Vaccines; aged; base; boys; clinical practice; data to knowledge; disparity reduction; epidemiologic data; evidence base; girls; high risk; high risk population; improved; medical specialties; penis; practice factors; prevent; social; social culture; social determinants; vaccination outcome; vaccine acceptance

PROJECT SUMMARY Human papillomavirus (HPV) is the most common form of sexually transmitted infection in the US, with approximately 79 million US individuals infected with HPV. The Advisory Committee on Immunization Practices (ACIP) recommends vaccine initiation between 11–12 years old, and it can be initiated as young as 9 years old. However, less than half of 13- to 17-year-old girls and less than one-third boys were fully vaccinated against HPV, much lower than the80% goal of Healthy People 2030. Significant barriers to HPV vaccination have been identified in 1) missed clinical opportunities due to provider and practice-related barriers, 2) low parental awareness, and 3) limited access to HPV vaccination services due to sociocultural and financial barriers. Asian Americans are disproportionally affected by HPV and HPV related conditions. Despite public health efforts, HPV vaccination rates were suboptimal in Asian American adolescents. Regional data showed low awareness of HPV vaccine and low vaccination rates in Chinese, Filipino, Japanese, Asian Indian, Korean, and Vietnamese subgroups. However, literature of the multilevel social determinants of HPV vaccine in Asian Americans is limited. Identifying high-risk groups and the multilevel mechanisms of HPV vaccine uptake are crucial in reducing disparities and increasing HPV vaccination rates in Asian American adolescents. This study will be the first study to use a nationally representative sample to examine the integrative effects of adolescent, parent, provider, and practice level factors in six Asian American subgroups. The proposed study will leverage the existing data from the 2010–2019 National Immunization Survey-Teen (NIS- Teen), the gold standard of US vaccination data. The study sample will include 6,019 boys and girls aged 13– 17 of Chinese (1,613), Filipino (1,383), Japanese (834), Indian (800), Korean (786), and Vietnamese (603) ethnicity. The specific aims are, Aim 1: to examine the integrative effects of adolescent, parent, provider, and practice level factors in their association with adolescent's HPV vaccine initiation and completion among six Asian American subgroups. Aim 2: to investigate the parent-reported reasons for delay or refusal of HPV vaccine for adolescents across six Asian American subgroups. Each specific aim addresses a unique research question that links practice/provider characteristics with adolescents/parent level factors, and together provide a comprehensive understanding of the social mechanisms of HPV vaccine uptake in Asian adolescents. Findings of this proposed study will provide subgroup-specific epidemiological data, guide the improvement of clinical practices, and inform the development of evidence-based strategies to reduce missed opportunities and improve adolescent vaccination in Asian American adolescents.

项目摘要 人乳头瘤病毒（HPV）是美国最常见的性传播感染形式， 美国约有7900万人感染HPV。免疫实践咨询委员会 （ACIP）建议在11-12岁之间开始接种疫苗，并且可以在9岁时开始接种。 然而，只有不到一半的13至17岁的女孩和不到三分之一的男孩完全接种了疫苗， HPV，远低于2030年健康人群80%的目标。HPV疫苗接种的重大障碍 已确定1）由于提供者和实践相关障碍而错过临床机会，2）低父母 3）由于社会文化和经济障碍，获得HPV疫苗接种服务的机会有限。 亚裔美国人受到HPV和HPV相关疾病的影响。尽管公众 健康努力，HPV疫苗接种率在亚裔美国青少年中是次优的。区域数据显示 中国人、菲律宾人、日本人、亚洲印度人、韩国人、 越南人的亚群。然而，亚洲人HPV疫苗多层次社会决定因素的文献 美国人有限。确定高危人群和HPV疫苗摄取的多层次机制是 这对减少亚裔美国青少年的差异和提高HPV疫苗接种率至关重要。 这项研究将是第一项使用全国代表性样本来检查综合性的研究。 青少年，父母，供应商和实践水平因素在六个亚裔美国人亚组的影响。的 拟议的研究将利用2010-2019年全国青少年免疫调查（NIS-）的现有数据。 青少年），美国疫苗接种数据的金标准。研究样本将包括6,019名13岁的男孩和女孩， 17名中国人（1，613）、菲律宾人（1，383）、日本人（834）、印度人（800）、韩国人（786）和越南人（603） 种族具体目标是， 目的1：研究青少年，父母，提供者和实践水平因素的综合影响， 他们与六名亚裔美国人青少年HPV疫苗接种开始和完成的关系 分组。 目的2：调查青少年推迟或拒绝接种HPV疫苗的原因 在六个亚裔美国人小组中。 每一个具体的目标解决了一个独特的研究问题，将实践/提供者的特点与 青少年/家长层面的因素，并共同提供了一个全面的了解社会 亚洲青少年的HPV疫苗摄取机制。 结果 的 这 提出 研究 将 提供 亚组特定的流行病学数据，指导临床实践的改进，并告知 制定循证战略，减少错失的机会，改善青少年疫苗接种 在亚裔美国青少年中。