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Impact of sex on respiratory response to wood smoke exposure

性别对木烟暴露呼吸反应的影响

基本信息

批准号：
10371435
负责人：
Meghan Elizabeth Rebuli
金额：
$ 16.12万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-07 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10371435
关键词：
Address Adverse effects Air Pollutants Air Pollution Area Bioenergetics Biological Response Modifiers Biology Biomass Breathing Cell Culture Techniques Cell physiology Cessation of life Chemicals Chronic Obstructive Pulmonary Disease Clinical Research Clinical Trials Communication Coughing Data Development Disease Educational workshop Electronic cigarette Epithelial Epithelial Cells Estrogens Exposure to Extramural Activities Female Funding Future Gene Expression Gene Proteins Genetic Genomics Goals Gonadal Steroid Hormones Grant Health Policy Heating Hormonal Hormone Receptor Host Defense Human Immune Immune response Impairment In Vitro Inflammation Inflammatory Response Inhalation Investigation K-Series Research Career Programs Knowledge Laboratories Link Lung Magnetic Resonance Imaging Measures Mediating Mentors Mentorship Modification Ozone Particulate Matter Physiological Physiology Play Predisposition Prevention Preventive measure Protein Analysis Public Health Pulmonary Function Test/Forced Expiratory Volume 1 Pulmonary Inflammation Randomized Regulation Reporting Research Research Personnel Respiratory Disease Respiratory Mucosa Respiratory physiology Role Sampling Severities Sex Bias Sex Differences Source Spirometry Sputum Structure of mucous membrane of nose Surface Techniques Testing Training Viral Wildfire Woman Work air filter airway immune response airway obstruction analysis pipeline asthma exacerbation base bronchial epithelium career career development cigarette smoke climate change cooking defense response design epidemiology study global health hormone regulation immune function immunoregulation in vivo inflammatory marker macrophage male men novel particle particle exposure pollutant premature programs pulmonary function respiratory respiratory health response sex skill acquisition skills tobacco products toxicant translational model wood smoke

项目摘要

PROJECT SUMMARY / ABSTRACT This career development proposal is focused on acquiring the necessary technical research and professional skills to establish an independent extramurally funded research program focused on investigating sex specific effects of air pollutants on respiratory health. This work builds on my current research, which focuses on the effects of air pollutants such as wood smoke, ozone, tobacco products, and e-cigarettes on the upper airway, specifically in the nasal mucosa. This TIEHR career development award will broaden my technical research skills and build needed expertise in lower airway assessment to effectively establish my independent career as an inhalation toxicologist. The research proposed in this grant is designed to test the central hypothesis that that genetic and hormonal sex mediate respiratory immune responses to wood smoke exposure. The aims of this grant include: 1) determining sex specific pulmonary physiology and immune effects of wood smoke exposure in vivo and 2) evaluating ex vivo interactive effects of wood smoke and sex hormone manipulation on primary lung epithelial and macrophage cell cultures. Data generated by the completion of this grant will fill a large gap in knowledge and understanding of sex specific respiratory responses to air pollutant exposure, specifically to wood smoke. It will also begin identifying mechanisms of genetic and hormonal regulation of immune response in the airway. More globally, this work will provide new targets of exploration for preventative or treatment measures against adverse responses to air pollutants. To complete my training, this grant unites multiple experts to synergistically support the goals of research and career training. The aims are designed to achieve training in: 1) clinical studies, 2) respiratory function assessment, 3) wood smoke chemical characterization, 4) lower airway sampling and sample analysis techniques, and 5) genomic analysis pipelines, in order to determine comprehensive effects of wood smoke exposure on the lower airway. This training will enhance my ability to systematically investigate sex-specific regulation of the immune system and responses to air pollutant exposure in human clinical studies. Training in each area will be provided by experts in their respective fields. Additionally, laboratory management, grantsmanship, scientific communication, mentorship, and career development skills will be attained through workshops, presentations, and other hands on training. Upon successful completion of the training portion of this grant, it is expected that I will be successful as an independent investigator and prepared to establish a R01 funded research program.

项目摘要/摘要