Traffic Exposure, Maternal Metabolome and Birth Outcomes Study (TEMMBO Study)
交通暴露、母亲代谢组和出生结果研究(TEMMBO 研究)
基本信息
- 批准号:10372213
- 负责人:
- 金额:$ 19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-16 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAdultAffectAfrican AmericanAgeAir PollutionAlgorithmsAllergic rhinitisAsthmaAtopic DermatitisBiologicalBiological FactorsBiological MarkersBirthChemicalsChildChild DevelopmentChild HealthChildhoodClinicalColorCommunitiesComplexDataDevelopmentDiseaseDoseDrug KineticsEnrollmentExperimental ModelsExposure toFirst Pregnancy TrimesterFood HypersensitivityFutureGestational AgeGoalsGrowthHealthIndividualInflammationInorganic ChemicalsInterventionKnowledgeLinkLongitudinal StudiesLow Birth Weight InfantMapsMaternal and Child HealthMeasurementMediatingMediationMetabolicMetabolic PathwayMethodsMinority GroupsModelingMolecularMothersNewborn InfantOrganic ChemicalsOutcomeOutcome StudyOxidative StressParticipantPathway interactionsPhenotypePregnancyPregnant WomenPremature BirthProcessPublishingResearchResearch PersonnelResolutionRiskSamplingShapesSourceStressTechnologyTestingThird Pregnancy TrimesterToxic Environmental SubstancesToxic effectUncertaintyWomanWorkadverse birth outcomesadverse pregnancy outcomebasecohortepigenomeexperiencefeature extractionfollow-uphealth disparityhigh throughput analysisimprovedimproved outcomein uteroindividual variationinnovationmetabolomemetabolomicsmicrobiomemultidisciplinaryneurodevelopmentnovelprenatalprenatal exposureresponsesocioeconomicsspatiotemporaltooltoxicanttraffic-related air pollution
项目摘要
PROJECT SUMMARY
Exposures to traffic-related air pollution (TRAP), a primary source of urban air pollution, during pregnancy have
been linked to adverse birth outcomes and the development of atopic diseases in childhood. Notably,
communities of color and the poor, especially African American (AA) women and children, disproportionately
experience both high TRAP exposures and adverse birth and child health outcomes. The mechanisms
underlying how maternal TRAP exposures may affect birth outcomes and shape child health disparities are still
largely unknown. This is due, in part, to the substantial challenges in accurately characterizing internal dose of
exposures and biological responses to TRAP. High-resolution metabolomics (HRM) -- a high-throughput analysis
method involving the identification and quantification of thousands of metabolic features associated with
exogenous exposure and endogenous processes -- has emerged as a powerful tool to improve exposure
assessment to complex environmental mixtures. In previous work among adults and adolescents, we used HRM
to detect metabolic perturbations following exposures to urban air pollution, where we identified and verified
several oxidative stress and inflammation-related pathways significantly associated with increased TRAP
exposures. These promising initial findings and prior published work on TRAP-mediated response related to birth
outcomes and child development have led us to hypothesize that elevated exposure to TRAPs during pregnancy
will result in perturbations in specific metabolic pathways, especially those linked to oxidative stress and
inflammation, which will increase risk for adverse birth outcomes including preterm birth and small-size-for-
gestational age. Our multidisciplinary team of investigators proposes to test this hypothesis in a cohort of 320
AA pregnant women with well-phenotyped birth outcomes and longitudinal high-resolution metabolic profiling. In
doing this, we will: 1) generate retrospective estimates of individual-level TRAP exposures using
spatiotemporally-resolved source dispersion models (Aim 1); 2) examine whether prenatal exposure to TRAP is
longitudinally associated with perturbations in maternal metabolome (Aim 2); and 3) explore whether maternal
metabolic pathways that associate with increased TRAP exposures also associate with adverse birth outcomes
(i.e. preterm birth and small-size-for-gestational age) under a mediation framework (Exploratory Aim 3). The
proposed Traffic Exposure, Maternal Metabolome and Birth Outcomes Study (TEMMBO Study) is highly
innovative in being the first longitudinal study to examine links among TRAP exposures, metabolic perturbations
and adverse birth outcomes in a socio-economically diverse, exceptionally phenotyped AA maternal-child cohort.
This linkage will include novel exposure assessment through external, traffic emission exposure modeling paired
with internal, high-resolution metabolomics data. Together, results will contribute towards identifying factors that
moderate associations between TRAP exposures and adverse birth outcomes, providing opportunities for
interventions to improve outcomes in exposed mothers and children.
项目总结
项目成果
期刊论文数量(0)
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Donghai Liang其他文献
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{{ truncateString('Donghai Liang', 18)}}的其他基金
Traffic Exposure, Maternal Metabolome and Birth Outcomes Study (TEMMBO Study)
交通暴露、母亲代谢组和出生结果研究(TEMMBO 研究)
- 批准号:
10217752 - 财政年份:2021
- 资助金额:
$ 19万 - 项目类别:
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