识别由于线粒体 DNA 缺陷引起的退化调节因子-猫眼课题宝

识别由于线粒体 DNA 缺陷引起的退化调节因子

批准号：

10205959

负责人：

MING GUO

金额：

$76.46万

依托单位：

UNIVERSITY OF CALIFORNIA LOS ANGELES

依托单位国家：

美国

项目类别：

财政年份：

2018

资助国家：

美国

项目状态：

已结题

起止时间：

2018-09-30 至 2023-05-31

来源：

https://reporter.nih.gov/project-details/10205959

关键词：

Adult Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease brain Alzheimer&apos s disease model Alzheimer&apos s disease pathology Amyloid beta-Protein Autophagocytosis Biological Biological Assay Brain Cells Cessation of life DNA Damage Deletion Mutation Disease Disease model Drosophila genus Drosophila melanogaster Drug Screening Drug Targeting Engineering Excision Eye FDA approved Financial compensation Free Radicals Functional disorder Gene Expression Gene Expression Profile Gene Expression Profiling Genes Genetic Transcription Genome Goals Human Intervention Knowledge Lead Mitochondria Mitochondrial DNA Mitotic Modeling Molecular Muscle Mutate Mutation Nerve Degeneration Nervous system structure Neurodegenerative Disorders Neuronal Dysfunction Neurons Organelles Oxidative Phosphorylation PINK1 gene Parkinson Disease Pathogenesis Pathology Pathway Analysis Pathway interactions Pharmaceutical Preparations Play Population Principal Investigator Production Public Health Quality Control RNA Interference Reporter Resources Risk Factors Role Screening Result Source System Systems Biology Tauopathies Testing Tissues Transgenic Model Transgenic Organisms age related age related neurodegeneration age-related muscle loss base cell type experimental study feeding frailty gain of function genome wide screen genome-wide heteroplasmy improved in vivo insight loss of function mitochondrial DNA mutation mitochondrial dysfunction mitochondrial genome muscle degeneration mutant overexpression parkin gene/protein programs public health relevance response sarcopenia tau Proteins tau expression tool

项目摘要

项目成果

MING GUO的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

Program Director/Principal Investigator (Last, First, Middle): Guo, Ming Project Summary/Abstract Neurodegenerative disorders affect 50% of the population over the age of 85. The strongest risk factor for most neurodegenerative disorders including Alzheimer’s disease is aging. Accumulation of mitochondrial DNA (mtDNA) mutations leads to cellular dysfunction, contributes to human aging and can be observed in age-related diseases such as Alzheimer’s disease, Parkinson’s disease and sarcopenia. Strategies that reduce the mtDNA deleterious mutation load and improve mtDNA quality control are likely to reduce the age-related pathologies of neurodegenerative diseases. We have generated unique transgenic tools in living Drosophila melanogaster post-mitotic tissues that contain engineered mixed mtDNA deletion mutations (deleterious heteroplasmy models). We aim to use these systems and system biology approaches to identify genes and compounds that lead to suppression or enhancement of the mitochondrial DNA quality control. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

期刊论文(0)

专著(0)

科研奖励(0)

会议论文