Academic Career Leadership Award in Aging

摘要 线粒体功能障碍是正常衰老的重要原因，与衰老相关的疾病，如 神经退行性疾病、阿尔茨海默病、心脏病、癌症、糖尿病和肌肉 石棺减少症。年龄是阿尔茨海默病的最强危险因素，而阿尔茨海默氏症的流行 65岁以上人口中的疾病每5年增加一倍。这个K07学术生涯的目标 领导奖是在加州大学洛杉矶分校建立一个世界级的衰老和线粒体健康中心，以促进 研究合作，并教育和培训这一重要领域的下一代领导人。这个 拟建的中心将是加州大学洛杉矶分校的第一个此类中心，由郭明博士领导。郭博士是一位 老牌内科医生兼科学家。她是痴呆症和认知障碍的临床专家，她还 研究线粒体在衰老和神经退行性疾病中的作用，包括阿尔茨海默氏症和 帕金森氏病的研究领域。该中心的目标将在三个方面实现：1)发展 核心资源，以吸引跨学科研究人员从事与老龄化有关的研究，并加强 合作研究项目，包括阿尔茨海默病研究的主要努力；2)创建 在衰老和线粒体生物学方面的综合跨学科培训和指导计划；以及3) 作为地方和国家关于衰老线粒体生物学研究的资源。长期的 中心的目标将是为多名调查员推动的提案获得外部资金，以及 职业发展学院补助金和机构培训补助金，以支持博士后培训 学者和老年研究人员。因此，该中心将是加州大学洛杉矶分校的一项新倡议，并将成为 研究人员致力于线粒体生物学、衰老和疾病的卓越灯塔 老龄化，重点是阿尔茨海默氏症。

Abstract Mitochondrial dysfunction is an important causal factor in normal aging, and aging-related diseases such as neurodegenerative disorders, Alzheimer's disease, cardiac disease, cancer, diabetes and muscle sarcopenia. Age is the strongest risk factor of Alzheimer’s disease, and the prevalence of Alzheimer’s disease doubles every 5 years in populations over the age of 65. The goal of this K07 Academic Career Leadership Award is to develop a world-class Center in Aging and Mitochondrial Health at UCLA to foster research collaborations, and to educate and train the next generation of leaders in this important field. The proposed Center will be the first of its kind at UCLA and will be led by Dr. Ming Guo. Dr. Guo is an established physician-scientist. She is a clinical specialist on dementia and cognitive impairment, who also investigates roles for mitochondria in aging and neurodegenerative diseases including Alzheimer’s and Parkinson’s disease in research realm. The Center's goals will be addressed in three aims: 1) to develop core resources to attract interdisciplinary investigators to engage in aging-related research and to enhance collaborative research projects, including a major effort in Alzheimer’s disease research; 2) to create a comprehensive interdisciplinary training and mentorship program in aging and mitochondrial biology; and 3) to serve as a local and national resource for research on mitochondrial biology in aging. The long-term goals of the Center will be to obtain extramural funding for multi-investigator driven proposals, as well as career development faculty grants and an institutional training grant to sustain the training of postdoctoral scholars and geriatric research fellows. Thus the Center will be a new initiative for UCLA and will be a beacon of excellence for investigators pursuing research into mitochondrial biology, aging and diseases of aging, with an emphasis on Alzheimer’s disease.