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Listening effort under auditory masking conditions in persons with acquired aphasia

获得性失语症患者在听觉掩蔽条件下的听力努力

基本信息

批准号：
10208854
负责人：
Sarah Noelle Villard
金额：
$ 8.96万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-03 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10208854
关键词：
Acoustics Acquired Aphasia Address Affect Age Aphasia Area Auditory Brain Chronic Cognitive Communication Communication impairment Communities Community Participation Complex Comprehension Data Development Electroencephalography Environment Exhibits Expenditure Family Fatigue Goals Hearing Impairment Individual Investigation Language Language Disorders Lead Lesion Linguistics Location Magnetic Resonance Imaging Masks Measures Mentors Methodology Mission National Institute on Deafness and Other Communication Disorders Outcome Patient Self-Report Performance Persons Phase Population Psychoacoustics Pupil Quality of life Rehabilitation therapy Reporting Research Resources Restaurants Scientist Short-Term Memory Signal Transduction Source Speech Stress Stroke Structure Training Treatment outcome United States Work age related career chronic stroke clinically relevant experience hearing impairment indexing negative affect operation perceived stress skills social social engagement social implication sound speech processing speech recognition stroke-induced aphasia tool

项目摘要

Project Summary/Abstract Aphasia is a common consequence of stroke, affecting approximately 1 million individuals in the United States and often persisting as a chronic condition. A growing body of work suggests that persons with chronic aphasia (PWA) are poorer than age- and hearing-matched controls at understanding speech when background sounds, or auditory maskers, are present. However, little is currently known about how auditory masking affects listening effort in PWA. Listening effort—that is, the cognitive resources directed towards decoding an auditory signal—is a key construct in the study of receptive speech processing. The presence of auditory maskers can often result in substantial increases in listening effort, which in turn can have significant negative ramifications for listeners, such as increased stress and fatigue, as well as the availability of fewer remaining resources to direct towards concurrent cognitive-linguistic operations. Because auditory masking is ubiquitous in real-world social and community environments (e.g. restaurants, stores, family/social gatherings), gaining a better understanding of this topic is crucial in understanding everyday communication in PWA. This proposal therefore consists of a close investigation into listening effort in aphasia under auditory masking conditions. This investigation is part of a comprehensive training plan that will allow the candidate to gain proficiency in specific tools—including pupillometry, electroencephalography (EEG), and structural magnetic resonance imaging (MRI)—and apply them to address several research aims, under the advisement of a mentoring team of experienced scientists. During the mentored phase, the project will aim to examine whether listening effort is higher in PWA than in age- and hearing-matched controls, as well as to identify possible relationships between brain lesion location and listening effort in PWA. During this initial phase, the candidate will receive training in pupillometry and EEG as measures of listening effort, as well as in structural MRI to collect data on lesion location, in order to compare listening effort in PWA vs controls. During the independent phase, the project will aim to assess the effects of several specific types of auditory masker manipulations, including masker type and location, on listening effort in PWA and controls. Finally, the effect of increased listening effort on verbal working memory in PWA will be directly examined. Throughout the project, careful consideration will be given to differentiating between the effects of aphasia, age, and hearing loss on listening effort. Results will provide critical information about how auditory masking affects PWA, and may have implications for social engagement, community participation, and quality of life in this population. Completion of the project will also allow the candidate to launch an independent research career investigating clinically relevant questions in aphasia and related neurogenic cognitive-communication disorders.

项目总结/摘要失语症是中风的常见后果，在美国约有100万人受到影响。状态，并经常作为一种慢性疾病持续存在。越来越多的研究表明，失语症（PWA）在理解背景语言时比年龄和听力匹配的对照组差。存在声音或听觉掩蔽物。然而，目前对听觉掩蔽是如何影响PWA中的听力努力。听力努力-也就是说，认知资源直接解码一个听觉信号是接受性言语加工研究中的一个关键结构。听觉的存在掩蔽语通常会导致听力努力的大幅增加，这反过来又会产生显著的负面影响。听众的后果，如增加的压力和疲劳，以及可用的更少的剩余资源，以指导并发认知语言操作。因为听觉掩蔽无处不在在真实的社交和社区环境中（如餐馆、商店、家庭/社交聚会），更好地理解这一主题对于理解PWA中的日常交流至关重要。因此，这项建议包括一个密切的调查，在听觉条件下失语症的听力努力掩蔽条件。这项调查是全面培训计划的一部分，该计划将使候选人能够熟练掌握特定的工具，包括瞳孔测量，脑电图（EEG）和结构磁共振成像（MRI）-并应用它们来解决几个研究目标，根据该协议，由经验丰富的科学家组成的指导团队。在指导阶段，该项目将旨在审查 PWA中的听力努力是否高于年龄和听力匹配的对照组，以及识别 PWA中脑损伤位置与听力努力之间的可能关系。在这个初始阶段，候选人将接受瞳孔测量和脑电图作为听力努力的衡量标准的培训，以及结构 MRI收集病变位置数据，以比较PWA与对照组的听力努力。期间在独立阶段，该项目将旨在评估几种特定类型的听觉掩蔽物的影响操纵，包括掩蔽物类型和位置，对PWA和控制中的听力努力的影响。最后，影响在PWA中，将直接检查增加的听力努力对口头工作记忆的影响。在整个项目中，将仔细考虑区分失语症、年龄和听力损失对倾听的努力结果将提供关于听觉掩蔽如何影响PWA的关键信息，对这一人群的社会参与、社区参与和生活质量的影响。完成该项目还将允许候选人开始独立的研究生涯，失语症和相关神经源性认知交流障碍的相关问题。