Pacific Northwest Center for Translational Environmental Health Research

西北太平洋转化环境健康研究中心

• 批准号: 10207636
• 负责人: EMILY HO
• 金额: $ 120.43万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10207636
• 关键词: Access to Information; Address; Air; Anatomy; Animal Experiments; Area; Behavioral; Big Data; Biological; Biological Assay; Biomedical Research; Categories; Cell Culture Techniques; Chemical Exposure; Chemicals; Commerce; Communities; Community Healthcare; Core Facility; Country; Data; Data Science; Devices; Diet; Disease; Drug Costs; Drug Targeting; Environmental Health; Event; Exhibits; Exposure to; Flame Retardants; Gene Expression; Goals; Hazardous Chemicals; Health; Health Personnel; Health Sciences; Home; Human; Human Biology; Individual; Industry; Institution; Interdisciplinary Study; International; Knowledge; Laboratories; Lead; Learning; Mammals; Manufacturer Name; Measurable; Methods; Modeling; Motor Activity; National Institute of Environmental Health Sciences; Nature; Noise; Nonprofit Organizations; Oregon; Organ; Organism; Outcome; Pacific Northwest; Pathway interactions; Persons; Pesticides; Pharmacologic Substance; Phenotype; Physiology; Poison; Population; Positioning Attribute; Predisposition; Public Health; Reproducibility; Research; Research Personnel; Research Project Grants; Robot; Running; Safety; Sampling; Scientist; Services; Signal Transduction; Soil; Specific qualifier value; Strategic Planning; Structure; Techniques; Technology; Toxic Environmental Substances; Toxic effect; Toxicology; Toxin; Translational Research; Translations; Universities; Water; Workplace; Zebrafish; adverse outcome; base; biological research; community engagement; cost; data to knowledge; decision research; drug development; drug discovery; evidence base; experience; experimental study; germ free condition; good laboratory practice; hazard; health literacy; human tissue; improved; insight; interest; member; microbiome; multidisciplinary; phthalates; remediation; response; skills; success; tool; transcriptomics; volatile organic compound; whole genome

OVERALL SUMMARY A dominant paradigm of environmental health science is the adverse outcome pathway. The adverse outcome pathway contains an external segment and an internal segment. The external segment is a toxic chemical that comes into contact with a person. That chemical may come from air, water, soil, or diet. The internal segment of the outcome pathway consists of a chain of events: the chemical interacts with a biological target, which triggers events that in turn lead to organ responses, organism responses, and population responses. This framework supports the most important environmental health science questions of our era: What chemical exposures cause disease? How do they cause disease? Why are some people more susceptible than others? How can we predict toxicity? How can we mitigate the impacts of hazardous chemicals? How can we reduce the use of toxic chemicals in commerce? To answer these questions, the OSU EHS CC has an established world-leading position in two of the world's most powerful technologies for investigating the adverse outcome pathway. To study the external segment, the Chemical Exposure (CXC) Facility Core has developed passive sampling wristbands that capture volatile and semi-volatile organic chemicals, as well as analytical techniques that can detect and quantify 1,500 compounds in a single run at low cost. To study the internal segment, the Zebrafish Biomedical Research (ZBR) Facility Core has built the world's largest specific-pathogen-free (i.e., low- experimental-noise) zebrafish environmental health sciences facility. Robots evaluate locomotor activity and look for physical and behavioral endpoints. Full-genome transcriptomics analyses reveal which gene expressions change before the phenotype changes. Together, the CXC and the ZBR give our investigators uniquely powerful experimental capabilities in EHS. Furthermore, these technologies are more than complementary; they are synergistic. We have applied wristband extracts as direct input to the zebrafish bioassay and identified the most toxic compounds in chemical mixtures via effects-directed analysis. Our Integrated Health Sciences Facilities and Community Engagement Cores will make these capabilities available to the extended EHS community via a new translational research model. We plan to co-produce knowledge with stakeholders in seven categories (residential communities, legislators, regulators, manufacturers, health care providers, pharmaceutical firms, and non-profit organizations). EHS CC members will conduct cross- sectoral multidisciplinary research with these stakeholders in order to generate actionable scientific evidence to guide stakeholder decisions that will improve environmental public health.

总体总结 环境健康科学的一个主导范式是不良结果途径。不利的后果 路径包含外部段和内部段。外部部分是一种有毒的化学物质 与一个人接触。这种化学物质可能来自空气、水、土壤或饮食。内部细分市场 结果途径由一系列事件组成：化学物质与生物靶标相互作用， 触发事件，进而导致器官反应、生物体反应和种群反应。这 框架支持我们时代最重要的环境健康科学问题：什么化学物质 暴露会导致疾病？它们是如何导致疾病的？为什么有些人比其他人更容易受到影响？多么 我们能预测毒性吗？我们如何减轻危险化学品的影响？我们如何才能减少使用 商业中的有毒化学物质？为了回答这些问题，俄亥俄州立大学EHS CC建立了世界领先的 拥有两项世界上最强大的研究不良后果途径的技术。至 研究外部部分，化学暴露(CXC)设施核心已开发出被动采样 捕捉挥发性和半挥发性有机化学品的腕带，以及可以 以低成本在一次运行中检测和量化1500种化合物。为了研究内部节段，斑马鱼 生物医学研究(ZBR)设施核心已经建立了世界上最大的无特定病原体(即，低 实验噪音)斑马鱼环境健康科学设施。机器人评估运动活动和 寻找物理和行为端点。全基因组转录组学分析揭示了 在表型改变之前，表达就会发生变化。CXC和ZBR一起给我们的调查人员 在EHS方面具有独特强大的实验能力。此外，这些技术不仅仅是 互补性；它们是协同的。我们已经将腕带提取物作为斑马鱼的直接输入 生物测定，并通过效应导向分析确定化学混合物中毒性最大的化合物。我们的 综合健康科学设施和社区参与核心将使这些能力可用 通过一种新的翻译研究模式扩展到EHS社区。我们计划联合制作知识 与七个类别的利益攸关方(住宅社区、立法者、监管机构、制造商、卫生 护理提供者、制药公司和非营利组织)。EHS CC成员将进行交叉 与这些利益攸关方进行部门多学科研究，以产生可操作的科学证据 引导利益相关者做出将改善环境公共健康的决策。