权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Prototype development and validation of soft robotic sensor arrays for mapping cardiac arrhythmia

用于绘制心律失常的软机器人传感器阵列的原型开发和验证

基本信息

批准号：
10378724
负责人：
Simon Dunham
金额：
$ 30.69万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10378724
关键词：
3D Print Ablation Acute Address American Anatomy Animal Model Animals Area Arrhythmia Atrial Fibrillation Blood flow Cardiac Catheters Collection Complex Development Device Designs Devices Disease Doctor of Philosophy Electrocardiogram Electrodes Electrophysiology (science)Ensure Goals Heart Atrium Hour In Vitro International Left atrial structure Maps Measurement Methods Mind Modeling Names Nature New Device Approvals Operative Surgical Procedures Pathway interactions Patients Performance Pharmacologic Substance Phase Play Polyurethanes Positioning Attribute Procedures Process Protocols documentation Pulsatile Flow Resolution Robotics Safety Series Signal Transduction Societies Source Speed Standardization Stretching Stroke prevention System Techniques Technology Testing Tissues Translations Validation base cardiac device cardiac implant design design verification electronic sensor experience experimental study flexibility in vivo iterative design mechanical properties minimally invasive nitinol novel pressure prevent process optimization prototype sensor side effect spatiotemporal success three-dimensional modeling tool usability verification and validation working group

项目摘要

ABSTRACT Roughly 20,000 patients per year are treated with ablation to treat atrial fibrillation (AF) because their condition cannot be managed by pharmaceuticals alone. While ablation protocols exist that can treat the disease in many cases, these procedures can be lengthy (2-4 hours) and are only somewhat effective (~60-70% success). This speed of the procedure is limited by electrophysiology tools, which still require serial mapping of the atrium based on articulating an electrode (or electrode array) around the patient anatomy. Furthermore, because AF is an unstable arrhythmia, it is difficult to construct full spatiotemporally resolved electrocardiograms from this type of serial mapping. The small subset of devices that provide simultaneous mapping of the entire chamber have serious limitations and often leave large portions of the chamber unmapped. Here, we propose the use of a flexible and conformal soft robotic sensor array that allows for rapid, efficient and high resolution mapping of the left atrium for treatment of AF. Our lab has already established prototype devices based in vitro assessments in patient specific 3D print models. In this proposal, we will develop an optimized prototype, and associated catheter, based on a series of in vivo surgical and finally, percutaneous large animal studies. Once optimized, during the R33 phase, we will perform a series of device validation protocols based on ISO and ASTM standards. Finally, during the R33 phase of the proposal we will validate the system in vivo using large animal models.

摘要