Data Management and Statistical Core

数据管理与统计核心

• 批准号: 10378616
• 负责人: Sudeshna Das
• 金额: $ 34.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378616
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Archives; Basic Science; Biological Markers; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Communities; Community Outreach; Computer software; Consultations; Data; Data Analyses; Data Set; Databases; Development; Disease; Education; Electronic Health Record; Engineering; Ensure; Epidemiology; Future; Genotype; Goals; Heterogeneity; Image; Impaired cognition; Individual; Informatics; Infrastructure; Link; Marshal; Massachusetts; Measures; Memory; Methodology; Methods; Participant; Publications; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Informatics; Resources; Sampling; Sampling Biases; Science; Scientist; Secure; Selection Bias; Source; Source Code; Standardization; Statistical Methods; Statistical Models; Subjects Selections; System; Terminology; Time; Training; Translational Research; Underrepresented Minority; Videotape; Visualization software; Vocabulary; analytical method; biobank; bioinformatics resource; clinical database; cohort; data exchange; data integration; data management; data quality; design; education research; flexibility; improved; informatics tool; innovation; interoperability; investigator training; novel; open source; query tools; rare condition; research study; statistical learning; statistics; symposium; tool; translational scientist; web site

Massachusetts Alzheimer’s Disease Research Center: Data Core The Data Management and Statistics Core (Data Core) of the Massachusetts Alzheimer’s Disease Research Center (MADRC) provides state-of-the-art data management and statistical expertise for the MADRC and affiliated research studies, for collaborative efforts with other ADRCs, and for national AD/ADRD research initiatives. The Data Core is an essential component of the MADRC research enterprise as it facilitates scientific rigor, regulatory-compliance and strong connectedness across cores within our Center, and with NACC and others outside our Center. It serves to minimize the burdens of research by optimizing study efficiencies through subject selection, endpoint selection, facile and adaptive designs, as well as provides guidance on rigorous study design and analyses. The Data Core provides informatics expertise and assistance, including data-management, timely data transmission to NACC, and query and reporting support to all the MADRC Cores. We will contribute to MADRC’s goal of understanding heterogeneity through formal statistical modeling and use of latent variables, through statistical learning approaches that accommodate longitudinal and survival data under biased sampling and through analysis of omics data. We will contribute to MADRC’s goal of accelerating toward a cure by developing, importing and disseminating innovative statistical methods and informatics tools that will optimize resources. The Core aims to marshal resources (Aims 1,2) to support clinical, translational, and basic research in AD/ADRD by contributing statistical and informatics expertise to interdisciplinary teams. The Core aims to develop new strategies (Aims 3,4) to provide practical and efficient study designs and unbiased analytic methods, and to implement innovative informatics resources. The Core aims to build the future (Aims 5,6) by collaborating with the Research Education Component (REC) to train clinical and translational researchers in quantitative methods and to attract quantitative scientists to AD/ADRD research. The Data Core provides guidance on scientific rigor: it assists MADRC researchers with study design and ensures valid and accurate analyses of studies across all MADRC Cores. The Data Core also advises MADRC researchers on data quality, version control and tracking measures. It ensures all systems are secure and within the Partners IT Infrastructure. The Core promotes open and reproducible science by disseminating methodological innovations to the scientific community and through data and software sharing.

马萨诸塞州阿尔茨海默病研究中心：数据核心 马萨诸塞州阿尔茨海默病研究的数据管理和统计核心(数据核心) 中心(MADRC)为MADRC和 附属研究，与其他ADRC的协作努力，以及国家AD/ADRD研究 首创精神。数据核心是MADRC研究企业的基本组件，因为它有助于 科学严谨、合规性和强大的跨中心核心连接性，以及 NACC和我们中心以外的其他人。它通过优化学习来最大限度地减少研究的负担 通过主题选择、终端选择、便捷和适应性设计提高效率，以及提供 指导严格的研究设计和分析。数据核心提供信息学专业知识和 协助，包括数据管理、及时向国家反腐败委员会传输数据以及对以下方面的查询和报告支持 所有的MADRC核心。 我们将帮助MADRC通过正式的统计建模和 通过适应纵向数据和生存数据的统计学习方法，使用潜在变量 在有偏抽样下，通过对组学数据的分析。我们将为MADRC的目标做出贡献 通过开发、引进和传播创新的统计方法和 将优化资源的信息学工具。核心目标是调集资源(目标1、2)以支持 通过贡献统计和信息学专业知识，在AD/ADRD方面进行临床、翻译和基础研究 跨学科团队。核心目标是制定新的战略(目标3、4)，以提供实用和有效的 研究设计和不偏不倚的分析方法，并实施创新的信息学资源。《核心》 旨在通过与研究教育部门(REC)合作培训未来(目标5，6) 临床和翻译研究人员的量化方法，并吸引量化科学家到AD/ADRD 研究。 数据核心提供科学严谨性方面的指导：它帮助MADRC研究人员进行研究设计和 确保对所有MADRC核心的研究进行有效和准确的分析。Data Core还为MADRC提供建议 研究人员对数据质量、版本控制和跟踪措施的研究。它确保所有系统都是安全的， 在合作伙伴IT基础设施内。核心通过传播以下信息促进开放和可重复的科学 通过数据和软件共享，向科学界提供方法创新。