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Bioinformatics and Modeling Core

Bioinformatics and Modeling Core
生物信息学和建模核心
批准号：
10378122
负责人：
Srinivas Ravi V Iyengar
金额：
$23.79万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-03-01 至 2024-02-29
来源：
https://reporter.nih.gov/project-details/10378122
关键词：
AcuteAneurysmAngiotensin IIBioinformaticsBiologicalBlood PressureCaringCell AdhesionCell CommunicationCell physiologyCellsChemicalsComputer AnalysisComputer ModelsDataDifferential EquationDiseaseDissectionDrug TargetingECM receptorEndothelial CellsEndotheliumEnsureEnvironmentExtracellular MatrixFeedbackGene Expression ProfilingGenesGeneticGoalsIndividualIntegrinsKnowledgeMeasurementMechanicsModelingMolecularMouse ProteinMusMutationOutputPathway AnalysisPathway interactionsProteinsReactionRegulatory PathwaySeedsSignal TransductionSmooth Muscle MyocytesStandardizationStatistical Data InterpretationStudy modelsSystemTestingTherapeutic InterventionThoracic Aortic AneurysmTimeTissuesTransforming Growth Factor betaVariantVascular Smooth Musclebasedifferential expressiondynamic systemexperimental studygraph theoryinsightinterestmRNA sequencingmechanical forcemechanical signalmechanotransductionmodel buildingmodel developmentmouse modelnovelpressureprotein protein interactionreceptorresponseshear stressspatial relationshiptherapeutic targettranscriptomicsvirtual

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中文摘要
翻译
核心B的总体意义在于它将提供标准化和严谨的生物信息学 以及对胸主动脉中发生的所有分子变化的计算模型分析 动脉瘤。这样的分析将使每个项目都能开发出一种机械的 理解发生的分子变化以及这些变化如何促进 向解剖方向发展。我们期待这样的综合分析将帮助我们解开 多种化学信号和物理力量如何相互作用来控制细胞中的功能 在疾病发生和发展过程中血管壁的变化。
英文摘要
The overall significance of Core B is that it will provide standardized and rigorous bioinformatics and computational modeling analyses of all the molecular changes that occur in thoracic aortic aneurysms. Such analyses will allow each of the projects to develop a mechanistic understanding of the molecular changes that occur and how these changes contribute to the progression towards dissection. We anticipate such integrated analyses will help us deconvolute how multiple chemical signals as well as physical forces interact to control functions in the cells of the vessel wall during disease origin and progression.
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