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Bioinformatics and Modeling Core

Bioinformatics and Modeling Core
生物信息学和建模核心
批准号：
10378122
负责人：
Srinivas Ravi V Iyengar
金额：
$23.79万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-03-01 至 2024-02-29
来源：
https://reporter.nih.gov/project-details/10378122
关键词：
AcuteAneurysmAngiotensin IIBioinformaticsBiologicalBlood PressureCaringCell AdhesionCell CommunicationCell physiologyCellsChemicalsComputer AnalysisComputer ModelsDataDifferential EquationDiseaseDissectionDrug TargetingECM receptorEndothelial CellsEndotheliumEnsureEnvironmentExtracellular MatrixFeedbackGene Expression ProfilingGenesGeneticGoalsIndividualIntegrinsKnowledgeMeasurementMechanicsModelingMolecularMouse ProteinMusMutationOutputPathway AnalysisPathway interactionsProteinsReactionRegulatory PathwaySeedsSignal TransductionSmooth Muscle MyocytesStandardizationStatistical Data InterpretationStudy modelsSystemTestingTherapeutic InterventionThoracic Aortic AneurysmTimeTissuesTransforming Growth Factor betaVariantVascular Smooth Musclebasedifferential expressiondynamic systemexperimental studygraph theoryinsightinterestmRNA sequencingmechanical forcemechanical signalmechanotransductionmodel buildingmodel developmentmouse modelnovelpressureprotein protein interactionreceptorresponseshear stressspatial relationshiptherapeutic targettranscriptomicsvirtual

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中文摘要
翻译
核心B的总体意义在于它将提供标准化和严格的生物信息学 和计算建模分析发生在胸主动脉的所有分子变化， 动脉瘤这样的分析将使每个项目都能制定一个机制， 了解发生的分子变化以及这些变化如何有助于 向解剖方向发展。我们预计这种综合分析将有助于我们解卷积 多种化学信号和物理力如何相互作用以控制细胞功能 在疾病的起源和发展过程中的血管壁。
英文摘要
The overall significance of Core B is that it will provide standardized and rigorous bioinformatics and computational modeling analyses of all the molecular changes that occur in thoracic aortic aneurysms. Such analyses will allow each of the projects to develop a mechanistic understanding of the molecular changes that occur and how these changes contribute to the progression towards dissection. We anticipate such integrated analyses will help us deconvolute how multiple chemical signals as well as physical forces interact to control functions in the cells of the vessel wall during disease origin and progression.
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