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Bioinformatics and Modeling Core

Bioinformatics and Modeling Core
生物信息学和建模核心
批准号：
10378122
负责人：
Srinivas Ravi V Iyengar
金额：
$23.79万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
项目状态：
已结题
起止时间：
2018-03-01 至 2024-02-29
来源：
https://reporter.nih.gov/project-details/10378122
关键词：
AcuteAneurysmAngiotensin IIBioinformaticsBiologicalBlood PressureCaringCell AdhesionCell CommunicationCell physiologyCellsChemicalsComputer AnalysisComputer ModelsDataDifferential EquationDiseaseDissectionDrug TargetingECM receptorEndothelial CellsEndotheliumEnsureEnvironmentExtracellular MatrixFeedbackGene Expression ProfilingGenesGeneticGoalsIndividualIntegrinsKnowledgeMeasurementMechanicsModelingMolecularMouse ProteinMusMutationOutputPathway AnalysisPathway interactionsProteinsReactionRegulatory PathwaySeedsSignal TransductionSmooth Muscle MyocytesStandardizationStatistical Data InterpretationStudy modelsSystemTestingTherapeutic InterventionThoracic Aortic AneurysmTimeTissuesTransforming Growth Factor betaVariantVascular Smooth Musclebasedifferential expressiondynamic systemexperimental studygraph theoryinsightinterestmRNA sequencingmechanical forcemechanical signalmechanotransductionmodel buildingmodel developmentmouse modelnovelpressureprotein protein interactionreceptorresponseshear stressspatial relationshiptherapeutic targettranscriptomicsvirtual

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The overall significance of Core B is that it will provide standardized and rigorous bioinformatics and computational modeling analyses of all the molecular changes that occur in thoracic aortic aneurysms. Such analyses will allow each of the projects to develop a mechanistic understanding of the molecular changes that occur and how these changes contribute to the progression towards dissection. We anticipate such integrated analyses will help us deconvolute how multiple chemical signals as well as physical forces interact to control functions in the cells of the vessel wall during disease origin and progression.
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