Women's airborne exposure and kidney health in Guatemala

危地马拉妇女的空气接触和肾脏健康

• 批准号: 10213525
• 负责人: Jaime Butler-Dawson
• 金额: $ 15.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213525
• 关键词: Acute; Address; Affect; Agricultural Workers; Agriculture; Air Pollutants; Air Pollution; Airborne Particulate Matter; Aromatic Polycyclic Hydrocarbons; Biological Markers; Biomass; Biometry; Burn injury; Caliber; Central America; Chemicals; Chronic Kidney Failure; Collection; Committee Members; Communities; Complement; Complex; Cooking Practices; Creatinine; Data; Dehydration; Development; Development Plans; Diabetes Mellitus; Disease; El Salvador; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epidemic; Epidemiologist; Etiology; Exposure to; Female; Female Adolescents; Funding Mechanisms; Future; Goals; Guatemala; Harvest; Health; Heat Stress Disorders; Heavy Metals; Home; Hour; Household; Hydration status; Hypertension; Individual; Injury to Kidney; Investigation; Kidney; Kidney Diseases; Knowledge; Latin America; Leadership; Measurable; Mentored Research Scientist Development Award; Mentors; Mentorship; Metals; Monitor; Morbidity - disease rate; Nicaragua; Nicaraguan; Occupational Health; Occupations; Organic Chemicals; Participant; Particulate Matter; Pathogenesis; Pesticides; Plants; Play; Premature Mortality; Prevalence; Prevention strategy; Public Health; Recurrence; Renal function; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Rural; Rural Community; Saccharum; Sampling; Science; Silicones; Statistical Methods; Structure; Techniques; Time; Training; Urine; Vulnerable Populations; Whole Blood; Woman; Work; Working Women; agricultural community; air sampling; anthropogenesis; base; career; career development; cooking; experience; feasibility testing; fine particles; male; member; monitoring device; mortality; multilevel analysis; neglect; nephrotoxicity; novel; occupational health/safety; operation; pollutant; professor; shift work; skills; sugar

Project Summary/Abstract An epidemic of unexplained kidney disease in young agriculture workers appeared at least two decades ago in Central America. The epidemic of chronic kidney disease of unknown origin (CKDu) causes premature mortality and predominantly affects rural communities. CKDu is not caused by traditional risk factors such as diabetes or hypertension. The hypothesis for the proposed study is that exposure to high concentrations of airborne contaminants will be associated with kidney injury in females at-risk for CKDu in Guatemala. Nearly all research to date has focused on males, neglecting preliminary data showing that females working in agriculture and living in agricultural communities are also affected by CKDu. Additionally, studies to date have largely overlooked consideration of air pollutants as contributors to CKDu etiology. In this proposal, we will characterize in (Aim months repeat airborne exposure to particulate matter (PM) and metals over a 24-hour monitoring period 50 female sugarcane workers and in 50 female community members not involved in the sugarcane sector 1). The 24-hour monitoring period will occur at two time points for each participant approximately 3 apart. In addition,we will conduct a quantitative screen of 125 organic chemicals via a silicone wristband worn by the participants over a 7-day period (Aim 2). We will evaluate the relationships between individual exposures (PM, metals, and organic chemicals) and a kidney biomarker of effect (creatinine) (Aims 1 and 2). The overall goal of the study is to increase understanding of risk factors for CKDu in women in order to facilitate targeted future research and prevention strategies. The proposed research is novel, addresses a research knowledge gap in an understudied, vulnerable population, and will serve as an important avenue for Dr. Butler-Dawson's career development. Dr. Butler-Dawson's plan will address four career objectives through mentored research, formal courses, structured tutorials, and practical experiences: (1) to increase my skill-set in environmental epidemiology; (2) to develop skills in exposure science; (3) to gain experience in advanced biostatistical techniques for multi- level modeling and interpretation; and (4) to effectively communicate scientific concepts and further develop leadership skills. Her mentor, Dr. John Adgate, Professor and Chair in the Department of Environmental and Occupational Health, as well as her committee members, Drs. Lee Newman (occupational health and safety practitioner), Katherine James (environmental epidemiologist), Richard Johnson (nephrologist), and James Crooks (biostatistician) will provide her with strong mentorship throughout this project. The outlined K01 award will provide protected time and resources for a rigorous training and mentoring period and subsequent transition to a successful independent researcher in environmental epidemiology.

项目概要/摘要 至少二十年前，在年轻农业工人中出现了一种不明原因的肾病流行病。 中美洲。不明原因慢性肾脏病（CKDu）的流行导致早产 死亡率，主要影响农村社区。 CKDu 不是由传统风险因素引起，例如 糖尿病或高血压。拟议研究的假设是，暴露于高浓度的 空气中的污染物与危地马拉有 CKDu 风险的女性的肾损伤有关。 迄今为止，几乎所有研究都集中在男性身上，忽视了初步数据显示，女性在工作中工作 农业和农业社区的生活也受到 CKDu 的影响。此外，迄今为止的研究表明 在很大程度上忽视了空气污染物作为 CKDu 病因学贡献因素的考虑。在本提案中，我们将 表征 在 （目的 月 在 24 小时监测期内重复暴露于空气中的颗粒物 (PM) 和金属 50 名女性甘蔗工人和 50 名不参与甘蔗行业的女性社区成员 1）。 24 小时监控期将在每个参与者的两个时间点进行，大约 3 分开。此外，我们还将通过硅胶对125种有机化学物质进行定量筛查 参与者在 7 天内佩戴的腕带（目标 2）。我们将评估之间的关系 个人暴露（PM、金属和有机化学品）和影响的肾脏生物标志物（肌酐）（目标 1 和2）。该研究的总体目标是增进对女性 CKDu 危险因素的了解，以便 促进有针对性的未来研究和预防战略。拟议的研究是新颖的，解决了 研究未充分研究的弱势群体的知识差距，并将作为重要的 巴特勒-道森博士的职业发展之路。 巴特勒-道森博士的计划将通过指导研究、正式课程、 结构化教程和实践经验：（1）提高我在环境流行病学方面的技能； (2) 培养暴露科学技能； (3) 获得先进生物统计技术的经验 水平建模和解释； (4) 有效传播科学理念并进一步 培养领导技能。她的导师约翰·阿德盖特 (John Adgate) 博士，教授兼系主任 环境和职业健康，以及她的委员会成员，博士。李·纽曼（职业 健康与安全从业者）、凯瑟琳·詹姆斯（环境流行病学家）、理查德·约翰逊 （肾脏病学家）和詹姆斯·克鲁克斯（生物统计学家）将在整个过程中为她提供强有力的指导 项目。概述的 K01 奖项将为严格的培训和指导提供受保护的时间和资源 期间以及随后转变为环境流行病学领域成功的独立研究员。