Building Resiliency Among Survivors of Cancers Diagnosed During Adolescence and Young Adulthood (AYAs): A Relaxation Response Resiliency Program for AYAs (3RP-AYA)

增强青春期和青年期 (AYAs) 癌症幸存者的复原力：AYA 放松反应复原力计划 (3RP-AYA)

• 批准号: 10213662
• 负责人: Giselle Katiria Perez-Lougee
• 金额: $ 16.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213662
• 关键词: Address; Adherence; Adolescence; Adolescent and Young Adult; Adult; Aftercare; Age; Award; Behavior Therapy; Behavioral; Behavioral Research; Behavioral Sciences; Biological; Biological Markers; Biometry; Cancer Etiology; Cancer Survivor; Cancer Survivorship; Characteristics; Childhood; Chronic; Chronic stress; Collection; Competence; Data; Development; Diagnosis; Distress; Doctor of Philosophy; Elements; Enrollment; Environment; Evidence based intervention; Evidence based program; Faculty; Feedback; Feeling; Female; Foundations; General Hospitals; Goals; Growth; Hair; Health; Health behavior; High-Risk Cancer; Hispanics; Hydrocortisone; Immune System Diseases; Intervention; Intervention Studies; Investigation; Knowledge; Late Effects; Lead; Life; Malignant Neoplasms; Massachusetts; Measures; Mental Health; Mentors; Mentorship; Methods; Mind-Body Method; Modeling; Morbidity - disease rate; Oncology; Outcome; Patient Self-Report; Patients; Phase; Physiological; Populations at Risk; Procedures; Process; Program Development; Psychiatric Social Work; Psychoneuroimmunology; Public Health; Qualitative Research; Quality of life; Randomized Controlled Trials; Relaxation; Research; Research Activity; Research Personnel; Resources; Risk; Role; Sampling; Stress; Stress and Coping; Survivors; Technology; Testing; Time; Training; Training Activity; Treatment outcome; Underserved Population; Videoconferencing; Vulnerable Populations; acceptability and feasibility; age group; base; body-mind; cancer diagnosis; career; childhood cancer survivor; design; efficacy testing; experience; feasibility testing; feasibility trial; follow-up; group intervention; immune function; improved; innovation; innovative technologies; instructor; intervention effect; medical schools; mortality; multi-component intervention; novel; perceived stress; physical conditioning; pilot trial; primary outcome; programs; psychologic; psychological outcomes; psychosocial; research data dissemination; resilience; response; satisfaction; secondary outcome; skills; stress management; stress reactivity; stressor; survivorship; theories; therapy development; virtual; virtual delivery; young adult

BACKGROUND: Survivors of cancers diagnosed during adolescence and young adulthood (AYA) represent a distinct group of survivors who are vulnerable to experiencing chronic stress and adverse health outcomes.1 Receiving a cancer diagnosis during a developmental period marked by peak socioemotional and physical changes has the potential to exacerbate typical adjustment problems and interfere with important age-specific milestones; despite their vulnerability, there are a lack of targeted programs to help AYAs manage these stressors. Using self-report and objective measures, this study proposes to develop and test the feasibility, acceptability and preliminary effects of an adapted, virtually delivered, evidence-based program, the Relaxation Response Resiliency Program (3RP),9 in promoting stress management and coping among survivors of AYA cancers. Specific Aims: Using a 2-phase, mixed methods approach,60 we propose to 1) adapt a mind-body resiliency group intervention for AYAs (3RP-AYA) that is aimed at reducing stress and promoting stress- management during the post-treatment transitional period; 2) conduct an open pilot (n=8) to test and refine the 3RP-AYA; 3a) examine, in a pilot randomized controlled trial (n=60), the feasibility, acceptability, and preliminary effects of a virtual, group-based, stress-management program for AYAs who are in the early stages of survivorship; and 3b) explore the feasibility and acceptability of collecting hair samples to examine intervention-related changes in stress as measured by cortisol. CANDIDATE: Dr. Perez is a Hispanic female childhood cancer survivor who is an instructor at the Massachusetts General Hospital/Harvard Medical School. This proposal will provide Dr. Perez with the requisite skills and mentored training she needs to fulfill her career goals of becoming an independent investigator with expertise in designing, testing, and disseminating innovative, integrative (i.e., combined behavioral and mind-body skills) interventions to improve physical and mental health outcomes among cancer survivors. MENTORING: To support her career goals, Dr. Perez has assembled a successful group of esteemed faculty with expertise in mixed methods and mind-body research (Elyse Park, PhD, MPH), behavioral intervention technology, behavioral science and research dissemination (Joseph Greer, PhD), cancer survivorship (Christopher Recklitis, PhD, MPH, Jeffrey Peppercorn, MD, MPH), stress and psychoneuroimmunology (PNI; John Denninger, MD, PhD), and biostatistics (Yuchiao Chang, PhD). TRAINING: Through the mentorship support, resource-rich environment, didactic training, and research activities afforded by this award, Dr. Perez will achieve the following training aims: 1) To develop expertise in designing and testing targeted integrative interventions for survivors of AYA cancer; 2) To acquire skills in the use of behavioral intervention technologies (BITs) as a platform to deliver and disseminate behavioral interventions for AYAs; and 3) To develop competence in PNI research within cancer survivorship.

背景：青春期和青春期被诊断为癌症的幸存者(AYA)是一种 易受慢性压力和不良健康后果影响的独特幸存者群体1 在社会情感和身体发育的高峰期接受癌症诊断 变化有可能加剧典型的调整问题，并干扰特定年龄的重要问题 里程碑；尽管它们很脆弱，但缺乏有针对性的计划来帮助AYA管理这些里程碑 压力源。采用自我报告和客观测量的方法，本研究建议开发和测试可行性， 调整后的、虚拟交付的循证计划的可接受性和初步效果 应对应变计划(3RP)，9促进阿亚幸存者的压力管理和应对 癌症。具体目标：使用两个阶段的混合方法，60我们建议1)调整身心 旨在减轻压力和促进压力的AYA弹性团体干预(3RP-AYA)- 在治疗后过渡期进行管理；2)进行开放试点(n=8)，以测试和完善 3RP-Aya；3a)在先导随机对照试验(n=60)中检查可行性、可接受性和 针对处于早期阶段的AYA的虚拟、以小组为基础的压力管理计划的初步效果 以及3b)探索采集头发样本进行检查的可行性和可接受性 皮质醇测量的与干预相关的压力变化。候选人：佩雷斯博士是西班牙裔女性 儿童癌症幸存者，马萨诸塞州综合医院/哈佛医学院的讲师。 这项提议将为佩雷斯博士提供她完成职业生涯所需的必要技能和指导培训 目标是成为一名独立的调查员，在设计、测试和传播创新、 综合干预(即结合行为和身心技能)以改善身心健康 癌症幸存者的结局。指导：为了支持她的职业目标，佩雷斯博士组织了一个 在混合方法和身心研究方面具有专业知识的受人尊敬的教员的成功团队(Elyse Park， 博士，公共卫生硕士)，行为干预技术，行为科学和研究传播(Joseph Greer， 博士)、癌症存活率(Christopher Recklitis博士、公共卫生硕士、杰弗里·佩珀科恩医学博士、公共卫生硕士)、压力和 心理神经免疫学(PNI；John Denninger，医学博士)和生物统计学(张玉桥，博士)。 培训：通过导师支持、资源丰富的环境、教学培训和研究 由该奖项提供的活动，佩雷斯博士将实现以下培训目标：1)发展专业知识 为癌症幸存者设计和测试有针对性的综合干预措施；2)在使用中获得技能 将行为干预技术(BITS)作为提供和传播行为干预的平台 Ayas；以及3)在癌症存活期内发展PNI研究能力。

项目成果

Development and feasibility of a virtual, synchronous mind-body resiliency intervention for fathers of children and youth with special healthcare needs.

为有特殊医疗保健需求的儿童和青少年的父亲开发虚拟同步身心弹性干预措施并探讨其可行性。

• DOI: 10.1016/j.bbii.2024.100052
• 发表时间: 2024
• 期刊: Brain behavior and immunity integrative
• 作者: Hall,DanielL;Fell,Lucy;Perez,GiselleK;Markwart,Michaela;Cammarata,Craig;Si,Yan;Cantillon,Audrey;Park,ElyseR;Kuhlthau,Karen
• 通讯作者: Kuhlthau,Karen

A virtual resiliency program for lymphoma survivors: helping survivors cope with post-treatment challenges.

• DOI: 10.1080/08870446.2020.1849699
• 发表时间: 2021-11
• 期刊: Psychology & health
• 影响因子: 3.3
• 作者: Perez GK;Walsh EA;Quain K;Abramson JS;Park ER
• 通讯作者: Park ER

Randomized Waitlist-Control Trial of a Web-Based Stress-Management and Resiliency Program for Adolescent and Young Adult Cancer Survivors: Protocol for the Bounce Back Study.

• DOI: 10.2196/34033
• 发表时间: 2022-01-26
• 期刊: JMIR research protocols
• 影响因子: 1.7
• 作者: Mizrach H;Goshe B;Park ER;Recklitis C;Greer JA;Chang Y;Frederick N;Abrams A;Tower MD;Walsh EA;Huang M;Kenney L;Homans A;Miller K;Denninger J;Usmani GN;Peppercorn J;Perez GK
• 通讯作者: Perez GK

Taboo Topics in Adolescent and Young Adult Oncology: Strategies for Managing Challenging but Important Conversations Central to Adolescent and Young Adult Cancer Survivorship.

• DOI: 10.1200/edbk_279787
• 发表时间: 2020-03-01
• 期刊: American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
• 作者: Perez, Giselle K;Salsman, John M;Rosenberg, Abby R
• 通讯作者: Rosenberg, Abby R