Evaluating the Feasibility of Combined Aerobic and Resistance Exercise Training and Impact on Energy Balance Regulation in Breast Cancer Survivors
评估有氧运动和抗阻运动相结合的可行性及其对乳腺癌幸存者能量平衡调节的影响
基本信息
- 批准号:10217034
- 负责人:
- 金额:$ 3.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-15 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdherenceAdoptionAdverse eventAerobicAerobic ExerciseAffectAgeAmericanAppetite RegulationAuthorshipAutomobile DrivingBehavioralBiometryBody CompositionBody WeightBreast Cancer TreatmentBreast Cancer survivorCancer PatientCancer SurvivorClinicalColoradoCommunicationControl GroupsDataDesire for foodDevelopmentDietary InterventionDietary intakeEarly DiagnosisEarly treatmentEducational InterventionEnergy IntakeEnergy MetabolismEnrollmentExerciseFatigueFatty acid glycerol estersFeedbackFinancial compensationFoodFoundationsFundingFutureGoalsGuidelinesHealthHumanHungerIndividualInterventionIntervention TrialKnowledgeLaboratoriesLeadLife StyleLightMalignant NeoplasmsMass in breastMentorsMetabolismNewly DiagnosedNutritionalNutritional statusObesityObservational StudyOncologyOutcomePainPeptide YYPhysical FunctionPhysical activityPhysiologicalPopulationPremenopausePublic HealthPublicationsQuality of lifeReactionRecommendationRegulationResearchResearch Project GrantsRestRiskSatiationStructureTrainingTraining ProgramsTranslatingUniversitiesWeightWomanacceptability and feasibilityactive methodbasecancer diagnosiscancer recurrencecancer therapycareercareer developmentcohortcomorbiditycravingdesigndietaryeffective interventionenergy balanceexercise interventionexercise programexercise trainingghrelinhedonicimprovedindexingmalignant breast neoplasmmode of exerciseobesity riskprogramsprospectiveresistance exerciseresponsesedentaryside effectskillsstrength trainingtherapy designtooltotal energy expendituretreatment effect
项目摘要
PROJECT SUMMARY/ABSTRACT
The applicant, Dr. Sarah Purcell, received graduate training in energy metabolism and body composition as it
pertains to nutritional status in individuals with newly-diagnosed cancer. Dr. Purcell's long-term goal is to
develop an independent research program that investigates energy balance as it relates to both nutrition and
exercise interventions in clinical populations, including cancer and obesity. Examining regulators of energy
balance such as appetite and physical activity will facilitate the development of more effective strategies to
mitigate fat mass gain, maintain physical function, improve quality of life and ultimately reduce the public health
burden of obesity. To help Dr. Purcell meet this goal, she has initiated postdoctoral research to investigate in
how components of energy balance such as appetite, energy intake, and non-exercise activity are affected by
structured exercise. Dr. Purcell and her mentoring team have developed a comprehensive training plan that
will build upon her expertise in nutritional oncology while expanding her knowledge of energy balance in the
context of exercise interventions, obesity, and oncology. Dr. Purcell’s primary training objectives include: 1)
Improve theoretical knowledge of energy intake regulation, exercise, metabolism, and biostatistics, 2) Develop
new research skills, 3) Lead a human intervention trial, 4) Enhance her professional development and network,
and 5) Improve communication skills, publication record, and grantsmanship. To achieve these goals, Dr.
Purcell’s proposed research project will 1) Examine the feasibility and acceptability of combining aerobic
exercise training with an ongoing resistance exercise training program compared to resistance training alone,
and 2) Elucidate potential alterations in appetite, energy intake, energy expenditure, and non-exercise physical
activity during twelve weeks of combined aerobic/resistance exercise compared to a sedentary control
condition among stage I-III breast cancer survivors. These activities will lead to several first-author publications
and provide preliminary data to support continued mentored career development funding (i.e. K01). Data
arising from this project will also inform the rationale and design of continued research aimed at understanding
whole-body mechanisms of energy balance regulation in response to exercise training. Dr. Purcell will also
have several opportunities for co-authorship within her sponsor’s and co-sponsor’s laboratories and other
collaborators at the University of Colorado. Collectively, these activities will provide an unprecedented
opportunity to develop Dr. Purcell’s research knowledge and skills, while providing a foundation for a
successful independent research career.
项目摘要/摘要
申请者莎拉·珀塞尔博士接受了能量代谢和身体成分方面的研究生培训。
与新诊断的癌症患者的营养状况有关。珀塞尔博士的长期目标是
制定独立的研究计划,研究能量平衡与营养和营养的关系
临床人群中的运动干预,包括癌症和肥胖症。审视能源监管机构
平衡食欲和体力活动将有助于制定更有效的策略,以
减轻脂肪增加,保持身体机能,提高生活质量,最终降低公众健康
肥胖的负担。为了帮助珀塞尔博士实现这一目标,她发起了博士后研究,以便在
能量平衡的组成部分,如食欲、能量摄入量和非运动活动是如何受到
有组织的锻炼。珀塞尔博士和她的指导团队制定了一项全面的培训计划,
将以她在营养肿瘤学方面的专业知识为基础,同时扩大她在
运动干预、肥胖和肿瘤学的背景。珀塞尔博士的主要培训目标包括:1)
提高能量摄入调节、运动、新陈代谢和生物统计学的理论知识,2)发展
新的研究技能,3)领导人类干预试验,4)加强她的专业发展和网络,
(5)提高沟通能力、出版记录和资质。为了实现这些目标,Dr。
珀塞尔提出的研究项目将1)检验结合有氧运动的可行性和接受性
与单独进行阻力训练相比,正在进行阻力训练的运动训练,
2)阐明食欲、能量摄入、能量消耗和非运动体力活动的潜在变化
有氧/耐力联合运动12周期间的活动量与静坐对照的比较
I-III期乳腺癌幸存者的状况。这些活动将导致几种第一作者出版物的出版
并提供初步数据以支持持续的辅导式职业发展资助(即K01)。数据
这一项目的产生也将提供继续研究的理论基础和设计,旨在了解
运动训练中能量平衡调节的全身机制。珀塞尔博士还将
在她的赞助商和联合赞助商的实验室和其他机构中有几次合著的机会
科罗拉多大学的合作者。总体而言,这些活动将提供前所未有的
有机会发展珀塞尔博士的研究知识和技能,同时为
成功的独立研究生涯。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sarah Anne Purcell其他文献
Sarah Anne Purcell的其他文献
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