Evaluating the Feasibility of Combined Aerobic and Resistance Exercise Training and Impact on Energy Balance Regulation in Breast Cancer Survivors

项目总结/摘要 申请人，博士莎拉珀塞尔，接受了研究生培训，在能量代谢和身体成分，因为它 与新诊断的癌症患者的营养状况有关。珀塞尔博士的长期目标是 制定一个独立的研究计划，调查能量平衡，因为它涉及到营养和 运动干预临床人群，包括癌症和肥胖。检查能量调节器 平衡，如食欲和体力活动将有助于制定更有效的战略， 减轻脂肪量增加，保持身体功能，提高生活质量，并最终减少公众健康 肥胖的负担。为了帮助珀塞尔博士实现这一目标，她开始了博士后研究， 能量平衡的组成部分，如食欲，能量摄入和非运动活动如何受到影响 结构性练习。珀塞尔博士和她的指导团队制定了一个全面的培训计划， 将建立在她在营养肿瘤学的专业知识，同时扩大她的能量平衡的知识， 运动干预、肥胖和肿瘤学的背景下。珀塞尔博士的主要培训目标包括：1） 提高能量摄入调节，运动，新陈代谢和生物统计学的理论知识，2）发展 新的研究技能，3）领导人类干预试验，4）加强她的专业发展和网络， （5）提高沟通能力、发表记录和声誉。为了实现这些目标，博士。 珀塞尔提出的研究项目将1）检查结合有氧运动的可行性和可接受性 与单独的阻力训练相比， 和2）阐明食欲、能量摄入、能量消耗和非运动体力的潜在变化 在12周的有氧/抗阻运动期间，与久坐对照组相比， I-III期乳腺癌幸存者的情况。这些活动将导致若干第一作者出版物 并提供初步数据，以支持继续指导职业发展资金（即K 01）。数据 该项目产生的结果还将为旨在了解的持续研究的原理和设计提供信息 运动训练对能量平衡调节的全身机制。珀塞尔博士还将 在申办者和共同申办者的实验室和其他实验室中有几次共同作者的机会 科罗拉多大学的合作者。总的来说，这些活动将提供前所未有的 有机会发展珀塞尔博士的研究知识和技能，同时为 成功的独立研究生涯。

PROJECT SUMMARY/ABSTRACT The applicant, Dr. Sarah Purcell, received graduate training in energy metabolism and body composition as it pertains to nutritional status in individuals with newly-diagnosed cancer. Dr. Purcell's long-term goal is to develop an independent research program that investigates energy balance as it relates to both nutrition and exercise interventions in clinical populations, including cancer and obesity. Examining regulators of energy balance such as appetite and physical activity will facilitate the development of more effective strategies to mitigate fat mass gain, maintain physical function, improve quality of life and ultimately reduce the public health burden of obesity. To help Dr. Purcell meet this goal, she has initiated postdoctoral research to investigate in how components of energy balance such as appetite, energy intake, and non-exercise activity are affected by structured exercise. Dr. Purcell and her mentoring team have developed a comprehensive training plan that will build upon her expertise in nutritional oncology while expanding her knowledge of energy balance in the context of exercise interventions, obesity, and oncology. Dr. Purcell’s primary training objectives include: 1) Improve theoretical knowledge of energy intake regulation, exercise, metabolism, and biostatistics, 2) Develop new research skills, 3) Lead a human intervention trial, 4) Enhance her professional development and network, and 5) Improve communication skills, publication record, and grantsmanship. To achieve these goals, Dr. Purcell’s proposed research project will 1) Examine the feasibility and acceptability of combining aerobic exercise training with an ongoing resistance exercise training program compared to resistance training alone, and 2) Elucidate potential alterations in appetite, energy intake, energy expenditure, and non-exercise physical activity during twelve weeks of combined aerobic/resistance exercise compared to a sedentary control condition among stage I-III breast cancer survivors. These activities will lead to several first-author publications and provide preliminary data to support continued mentored career development funding (i.e. K01). Data arising from this project will also inform the rationale and design of continued research aimed at understanding whole-body mechanisms of energy balance regulation in response to exercise training. Dr. Purcell will also have several opportunities for co-authorship within her sponsor’s and co-sponsor’s laboratories and other collaborators at the University of Colorado. Collectively, these activities will provide an unprecedented opportunity to develop Dr. Purcell’s research knowledge and skills, while providing a foundation for a successful independent research career.