Evaluating the Feasibility of Combined Aerobic and Resistance Exercise Training and Impact on Energy Balance Regulation in Breast Cancer Survivors

项目概要/摘要 申请人 Sarah Purcell 博士接受了能量代谢和身体成分方面的研究生培训，因为 与新诊断癌症患者的营养状况有关。 Purcell 博士的长期目标是 制定一个独立的研究计划，调查与营养和营养相关的能量平衡 对临床人群的运动干预，包括癌症和肥胖症。检查能源监管机构 食欲和体力活动等平衡将有助于制定更有效的策略 减轻脂肪量增加，维持身体机能，提高生活质量，最终降低公众健康 肥胖的负担。为了帮助 Purcell 博士实现这一目标，她启动了博士后研究，以调查 能量平衡的组成部分，如食欲、能量摄入和非运动活动如何受到影响 结构化练习。 Purcell 博士和她的指导团队制定了一项全面的培训计划， 将利用她在营养肿瘤学方面的专业知识，同时扩展她在能量平衡方面的知识 运动干预、肥胖和肿瘤学的背景。 Purcell 博士的主要培训目标包括：1) 提高能量摄入调节、运动、新陈代谢和生物统计学的理论知识，2) 发展 新的研究技能，3）领导一项人类干预试验，4）增强她的专业发展和网络， 5) 提高沟通技巧、出版记录和资助能力。为了实现这些目标，博士。 Purcell 提出的研究项目将 1）检验结合有氧运动的可行性和可接受性 与单独的阻力训练相比，持续进行阻力训练计划的运动训练， 2) 阐明食欲、能量摄入、能量消耗和非运动体力的潜在变化 与久坐对照相比，十二周有氧/抗阻联合运动期间的活动量 I-III 期乳腺癌幸存者的状况。这些活动将导致发表几篇第一作者出版物 并提供初步数据以支持持续指导的职业发展资金（即 K01）。数据 该项目的成果还将为旨在理解的持续研究的基本原理和设计提供信息 响应运动训练的能量平衡调节的全身机制。珀塞尔博士还将 在其申办者和共同申办者的实验室以及其他机构内有多次共同作者的机会 科罗拉多大学的合作者。总的来说，这些活动将提供前所未有的 发展 Purcell 博士的研究知识和技能的机会，同时为 成功的独立研究生涯。

PROJECT SUMMARY/ABSTRACT The applicant, Dr. Sarah Purcell, received graduate training in energy metabolism and body composition as it pertains to nutritional status in individuals with newly-diagnosed cancer. Dr. Purcell's long-term goal is to develop an independent research program that investigates energy balance as it relates to both nutrition and exercise interventions in clinical populations, including cancer and obesity. Examining regulators of energy balance such as appetite and physical activity will facilitate the development of more effective strategies to mitigate fat mass gain, maintain physical function, improve quality of life and ultimately reduce the public health burden of obesity. To help Dr. Purcell meet this goal, she has initiated postdoctoral research to investigate in how components of energy balance such as appetite, energy intake, and non-exercise activity are affected by structured exercise. Dr. Purcell and her mentoring team have developed a comprehensive training plan that will build upon her expertise in nutritional oncology while expanding her knowledge of energy balance in the context of exercise interventions, obesity, and oncology. Dr. Purcell’s primary training objectives include: 1) Improve theoretical knowledge of energy intake regulation, exercise, metabolism, and biostatistics, 2) Develop new research skills, 3) Lead a human intervention trial, 4) Enhance her professional development and network, and 5) Improve communication skills, publication record, and grantsmanship. To achieve these goals, Dr. Purcell’s proposed research project will 1) Examine the feasibility and acceptability of combining aerobic exercise training with an ongoing resistance exercise training program compared to resistance training alone, and 2) Elucidate potential alterations in appetite, energy intake, energy expenditure, and non-exercise physical activity during twelve weeks of combined aerobic/resistance exercise compared to a sedentary control condition among stage I-III breast cancer survivors. These activities will lead to several first-author publications and provide preliminary data to support continued mentored career development funding (i.e. K01). Data arising from this project will also inform the rationale and design of continued research aimed at understanding whole-body mechanisms of energy balance regulation in response to exercise training. Dr. Purcell will also have several opportunities for co-authorship within her sponsor’s and co-sponsor’s laboratories and other collaborators at the University of Colorado. Collectively, these activities will provide an unprecedented opportunity to develop Dr. Purcell’s research knowledge and skills, while providing a foundation for a successful independent research career.