MOLECULAR STRUCTURE-FUNCTION RELATIONSHIPS OF THE NORADRENALINE TRANSPORTER & DRUG ACTION

去甲肾上腺素转运蛋白的分子结构-功能关系

• 批准号: nhmrc : 102605
• 负责人: Dr Lesley Bryan-Lluka
• 金额: $ 12.6万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-structure-function-drug-action/81644
• 关键词: MOLECULAR; STRUCTURE; FUNCTION; RELATIONSHIPS; NORADRENALINE

The transmission of impulses by nerves is dependent on the release of chemicals, termed neurotransmitters, from the nerve. The neurotransmitter causes its effects and then its action is usually terminated by membrane proteins that transport the chemical back into the nerve. These proteins are termed 'transporters'. In the brain, psychostimulants such as cocaine and also drugs that are used in the therapy of conditions such as depression block the activity of the transporters for the neurotransmitters, noradrenaline, serotonin and dopamine. Recently, the structures of the transporter proteins have been determined using molecular biology techniques. The focus of this project is to determine the parts of the noradrenaline transporter protein structure that are important in determining its functions, utilising the knowledge that we now have about its molecular structure. This will lead to exciting advances in understanding the function of the noradrenaline transporter and these advances should ultimately lead to the development of more effective antidepressant drugs and of drugs to prevent the effects of psychostimulants such as cocaine.

神经脉冲的传递取决于神经释放的化学物质（称为神经递质）。神经递质产生作用，然后其作用通常被膜蛋白终止，膜蛋白将化学物质转运回神经。这些蛋白质被称为“转运蛋白”。在大脑中，可卡因等精神兴奋剂以及用于治疗抑郁症等疾病的药物会阻断神经递质、去甲肾上腺素、血清素和多巴胺转运蛋白的活性。最近，利用分子生物学技术确定了转运蛋白的结构。该项目的重点是利用我们现在对其分子结构的了解，确定去甲肾上腺素转运蛋白结构中对其功能至关重要的部分。这将在理解去甲肾上腺素转运蛋白的功能方面带来令人兴奋的进展，这些进展最终将导致更有效的抗抑郁药物和预防可卡因等精神兴奋剂影响的药物的开发。