Expanding the synthetic utility of natural product biosynthetic enzymes

扩大天然产物生物合成酶的合成用途

基本信息

  • 批准号:
    10217184
  • 负责人:
  • 金额:
    $ 37.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-08-01 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary Oxidative transformations are one of the most utilized classes of reactions, indispensible in the synthesis of pharmaceutical agents and small molecules used to study biological systems. While significant strides have been made in developing powerful methods for oxidative reactions, it remains challenging to carry out these transformations with high levels of chemo-, site- and stereoselectivity on complex molecules. In contrast to small molecule catalysts and reagents, enzymes from natural product biosynthetic pathways have evolved to carry out oxidation reactions with high levels of selectivity. The discovery of oxidative enzymatic reactions and development of the utility of these catalysts has the potential to enable to synthetic strategies and grant us access to new molecules with potent biological activity. This proposal describes several strategies for developing robust enzyme-mediated oxidation reactions and leveraging these tools for the streamlined synthesis of molecules with pharmaceutical potential. This work takes advantage of the powerful reactivity and selectivity that Nature has evolved within its synthetic routes to complex secondary metabolites. From this starting point provided by Nature, we (1) characterize the function of each enzyme and define the substrate flexibility of each enzyme, (2) use structure-guided protein engineering to alter the innate site- and stereoselectivity of a given catalysts, (3) develop chemomimetic biocatalytic reactions and (4) utilize strategies to expand the substrate scope of a given enzyme. Together, these approaches provide a suite of versatile catalysts that will be applied to the synthesis of biologically active target molecules. The biological properties of these molecules will be evaluated through direct collaborations with investigators at the University of Michigan Medical School as well as the Center for Chemical Genomics High Throughput Screening facility at the University of Michigan Life Sciences Institute. In summary, this proposal describes the development of chemo-, site- and stereoselective oxidative transformations mediated by biosynthetic enzymes. These methods will directly enable the synthesis of complex biologically active molecules relevant to human health.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Alison Narayan其他文献

Alison Narayan的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Alison Narayan', 18)}}的其他基金

High throughput chemoenzymatic synthesis of antimalarial compounds
抗疟化合物的高通量化学酶法合成
  • 批准号:
    10526962
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
Undergrad Supplement: Expanding the synthetic utility of natural product biosynthetic enzymes
本科生补充:扩大天然产物生物合成酶的合成效用
  • 批准号:
    10592791
  • 财政年份:
    2017
  • 资助金额:
    $ 37.27万
  • 项目类别:
Expanding the synthetic utility of enzymes
扩大酶的合成用途
  • 批准号:
    10406622
  • 财政年份:
    2017
  • 资助金额:
    $ 37.27万
  • 项目类别:
Expanding the synthetic utility of natural product biosynthetic enzymes
扩大天然产物生物合成酶的合成用途
  • 批准号:
    9382096
  • 财政年份:
    2017
  • 资助金额:
    $ 37.27万
  • 项目类别:
Expanding the synthetic utility of natural product biosynthetic enzymes-Equipment Supplement
扩大天然产物生物合成酶的合成用途-设备补充
  • 批准号:
    9895054
  • 财政年份:
    2017
  • 资助金额:
    $ 37.27万
  • 项目类别:
Expanding the synthetic utility of natural product biosynthetic enzymes - Diversity Supplement
扩大天然产物生物合成酶的合成用途 - Diversity Supplement
  • 批准号:
    10392550
  • 财政年份:
    2017
  • 资助金额:
    $ 37.27万
  • 项目类别:
Expanding the synthetic utility of enzymes
扩大酶的合成用途
  • 批准号:
    10656414
  • 财政年份:
    2017
  • 资助金额:
    $ 37.27万
  • 项目类别:

相似海外基金

The concept for the evolutionary studies of the human mind and behaviors that are consistent with modern biological sciences
与现代生物科学相一致的人类思维和行为进化研究的概念
  • 批准号:
    23K00262
  • 财政年份:
    2023
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Acquisition of a Glacios Cryo-TEM for the Biological Sciences Imaging Resource
采购 Glacios Cryo-TEM 用于生物科学成像资源
  • 批准号:
    10632855
  • 财政年份:
    2023
  • 资助金额:
    $ 37.27万
  • 项目类别:
Becoming a Scientist: A Study of Identity Balance and the Persistence of Hispanic Undergraduate Students in Engineering and Biological Sciences
成为一名科学家:身份平衡与西班牙裔工程和生物科学本科生的坚持研究
  • 批准号:
    2334638
  • 财政年份:
    2023
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Continuing Grant
RaMP: Research and Mentoring for Postbaccalaureates in Biological Sciences at the University of Puerto Rico (RaMP-UP)
RaMP:波多黎各大学生物科学学士后研究和指导 (RaMP-UP)
  • 批准号:
    2216584
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Standard Grant
Life and physical sciences interface: Topological underpinnings of data with application to biological sciences
生命与物理科学接口:数据的拓扑基础及其在生物科学中的应用
  • 批准号:
    BB/X004244/1
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Research Grant
High performance mass spectrometry: applications for the Cambridge biological sciences community
高性能质谱:剑桥生物科学界的应用
  • 批准号:
    BB/W019620/1
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Research Grant
Biological Sciences Program at The Gerontological Society of America's 2022 Annual Scientific Meeting
美国老年学会 2022 年科学年会生物科学项目
  • 批准号:
    10469163
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
MRI: Acquisition of a High-Resolution Mass Spectrometer for Research in Chemical Synthesis, Materials, and Biological Sciences
MRI:购买高分辨率质谱仪用于化学合成、材料和生物科学研究
  • 批准号:
    2215975
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Standard Grant
Partnering with Rural and Low-income Students for Academic Success in the Biological Sciences
与农村和低收入学生合作,在生物科学领域取得学业成功
  • 批准号:
    2221637
  • 财政年份:
    2022
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Standard Grant
Pelagic fish and shark survivability in recreational fisheries - Biological Sciences PhD Studentship (NERC GW4+ DTP funded)
休闲渔业中的远洋鱼类和鲨鱼生存能力 - 生物科学博士生奖学金(NERC GW4 DTP 资助)
  • 批准号:
    2556480
  • 财政年份:
    2021
  • 资助金额:
    $ 37.27万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了