LEveraging A viRtual eNvironment (LEARN) to Enhance Prevention of HIV-related Comorbidities in at-risk Minority MSM

利用虚拟环境(学习)加强艾滋病毒相关合并症的预防 在高危少数民族MSM中 项目摘要 应聘者是一名具有慢性病和信息学专业知识的助理教授，其 职业生涯的首要目标是利用卫生技术干预措施为实现健康作出贡献 通过行为改变和预防不同和服务不足的人群的合并症实现的公平 人类免疫缺陷病毒。为了支持这一目标并利用他们迄今的经验， 指导职业发展奖培训将集中在三个领域：1)心血管疾病预防 2)虚拟环境(VE)理论与设计；3)先进的研究设计方法 和创新的分析方法。培训将包括授课和体验式培训、研讨会 加强，并出席国家科学会议。候选人得到了杰出团队的支持 导师是各自领域的领导者，拥有成功的NIH资助的研究项目 心血管疾病和慢性病预防、以技术为基础的干预措施；以及 方法论设计。这项研究的长期目标是利用VE作为一种手段来增加对 在线社会支持和增加健康促进技能，可以转移到现实世界和结果 在预防艾滋病毒相关的心血管和代谢疾病方面。这样做的总体目标是 申请有两个方面：1)接受必要的培训和研究经验，成为一个独立的 使用卫生技术干预措施预防艾滋病毒相关慢性病的研究人员，以及2) 满足NIH/NHLBI对多元化早期职业科学劳动力的呼吁(例如，RFA-HL-19-025)。作为以下内容的一部分 在指导研究中，将进行探索性等待名单对照可行性临床试验。目标 1：探索生活在少数族裔MSM中对艾滋病毒相关共病(即重要性、关注度)的看法 艾滋病毒携带者。目标2：测试VE解决艾滋病毒预防问题的可行性、可接受性和初步效果 通过行为和心理社会结局与心血管疾病共病相关。目标2a：描述社会 使用从基于VE的干预中收集的过程数据来确定网络结构和行为。在目标1中，15 定性访谈将探索人们对艾滋病毒相关合并症的看法。目标2将在#年提出 迭代的多阶段方法。在第一阶段，我将在计划部署之前对VE进行Beta测试 临床可行性试验。在第二阶段，我将使用在虚拟环境中学习(LIVE©)平台进行 80名成年、少数民族、男男性行为者HIV携带者和HIV相关高危人群的等待名单对照可行性临床试验 合并症。虽然这种类型的技术已经有效地应用于糖尿病和其他慢性病， 如何利用VES促进预防疾病的知识和健康促进行为 男男性接触者中与HIV相关的合并症尚未被研究，这使得这一建议具有重要意义和创新性。它是 预计指导发展奖研究将是预防艾滋病领域的早期步骤 少数民族男男性接触者中与艾滋病毒相关的合并症，并为R01资助的临床试验提供了基础。

LEveraging A viRtual eNvironment (LEARN) to Enhance Prevention of HIV-related Comorbidities in at-risk Minority MSM Project Summary The candidate is an Assistant Professor with expertise in chronic illness and informatics whose overarching career goal is to use health technology interventions to contribute to the achievement of health equity through behavior change and comorbidity prevention in diverse and underserved populations living with Human Immunodeficiency Virus. In order to support this goal and leverage their experiences to date, the Mentored Career Development Award training will focus on three areas: 1) Cardiovascular disease prevention in ethnic/racial MSM, 2) Virtual environment (VE) theory and design, 3) advanced research design methods and innovative analytic approaches. Training will consist of didactic and experiential training, workshops intensives, and attendance at national scientific meetings. The candidate is supported by a distinguished team of mentors who are leaders in their respective fields with successful NIH-funded programs of research in cardiovascular disease and chronic illness prevention, technology-based interventions; and advanced methodological design. The long-term goal of this research is to utilize a VE as a means to increase access to online social supports and increase health promotion skills that can be transferred to the real world and result in the prevention of HIV-related cardiovascular and metabolic conditions. The overall objective of this application is twofold: 1) to receive the training and research experience necessary to become an independent researcher who uses health technology interventions for HIV-related chronic illness prevention, and 2) to address the NIH/NHLBI's call for a diverse early-career scientific workforce (e.g. RFA-HL-19- 025). As part of the mentored research, an exploratory sequential wait-list control feasibility clinical trial will be conducted. Aim 1: Explore perceptions about HIV-related comorbidities (i.e., importance, concern) among minority MSM living with HIV. Aim 2: Test the feasibility, acceptability and preliminary effects of a VE to address prevention of HIV- related CVD comorbidities through behavioral and psychosocial outcomes. Aim 2a: Characterize the social network structure and behaviors using process data collected from the VE-based intervention. In Aim 1, 15 qualitative interviews will explore perceptions of HIV-related comorbidity concerns. Aim 2 will be addressed in an iterative multiphase approach. In phase one I will beta test the VE prior to deployment in the proposed clinical feasibility trial. In phase two, I will use the Learning in Virtual Environments (LIVE©) platform to conduct a wait-list control feasibility clinical trial with 80 adult, minority, MSM living with HIV and at-risk for HIV-related comorbidities. While this type of technology has been applied effectively in diabetes and other chronic disease, the ways in which VEs can be used to facilitate knowledge and health promoting behaviors for prevention of HIV-related comorbidities in MSM has not been studied, making this proposal significant and innovative. It is expected that the Mentored Development Award study will represent an early step in the field for prevention of HIV-related comorbidities in ethnic minority MSM and provide the foundation for a R01-funded clinical trial.