Integrating the Exposome into Longitudinal Multiomics Profiling

将暴露组整合到纵向多组学分析中

• 批准号: 10220979
• 负责人: Sophia Miryam Schüssler-Fiorenza Rose
• 金额: $ 20.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220979
• 关键词: Acute; Address; Adipose tissue; Adverse effects; Affect; Age; American; Antibiotics; Award; Biological; Biological Assay; Blood; Blood Glucose; Body Weight; Body Weight decreased; Centers for Population Health; Certification; Chemical Exposure; Clinical; Complex; Cultural Evolution; Data; Data Analyses; Development; Diabetes Mellitus; Discipline; Disease; Doctor of Philosophy; Environmental Exposure; Environmental Pollution; Epidemic; Equipment and supply inventories; Ethnic group; Evolution; Exercise; Exposure to; Fiber; Genes; Goals; Grant; Health; Health Sciences; Human; Immune System Diseases; Impairment; Insulin Resistance; Interdisciplinary Study; Intervention; Joints; Laboratories; Lead; Learning; Life Experience; Life course epidemiology; Link; Lipids; Longevity; Mathematical Biology; Measures; Medicine; Mentors; Metabolic; Methods; Modeling; Molecular; Multiomic Data; Nervous System Trauma; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Organic Chemicals; Outcome; Participant; Pathway interactions; Patients; Physical Medicine; Physical Rehabilitation; Physicians; Plasma; Polychlorinated Biphenyls; Precision Health; Property; Psychoneuroimmunology; Race; Racial Equity; Recombinant DNA; Research; Risk; Role; Sampling; Scientist; Shapes; Source; Spectrometry; Spinal cord injury; Stress; Surveys; System; Systems Biology; Time; Toxicant exposure; Urine; Vaccination; Variant; Weight Gain; Work; advanced analytics; analytical method; behavior measurement; blood glucose regulation; career; causal model; chemokine; cohort; cytokine; data repository; design; diabetes risk; diet and exercise; experience; exposed human population; gut microbiome; high risk; improved; innovation; ion mobility; learning algorithm; lipidome; metabolome; microbiome; multiple omics; network models; novel; novel strategies; obese person; organochlorine pesticide; personalized medicine; polybrominated diphenyl ether; population based; population health; precision medicine; programs; psychosocial; racial and ethnic; resilience; skills; social genomics; societal costs; tool; transcriptome; transcriptome sequencing

PROJECT SUMMARY/ABSTRACT This is an application for a K08 award for Sophia Miryam Schüssler-Fiorenza Rose, MD, PhD, a Physical Medicine and Rehabilitation physician with subspecialty certification in Spinal Cord Injury Medicine and a Population Health Scientist. Her long-term goal is to lead a multidisciplinary research team that can apply complex systems approaches and other novel analytic methods to address the effects of adverse exposures on neurorecovery and long term health in those affected by neurotrauma and related diseases. This K08 award will provide Dr. Rose the support necessary to accomplish the following educational goals. 1. Develop expertise assessing the environmental, psychosocial and internal exposome. 2. Develop expertise in assessing biological effects of exposures using longitudinal multiomics profiling. 3. Develop advanced skills in longitudinal multiomics data analysis, complex systems and causal modeling approaches. 4. Develop skills in leading multidisciplinary research teams. 5. Develop translational skills and design a study to validate some of the findings of the research in a clinical or population based sample that will serve as a launching point for her independent research career. To achieve these goals, Dr. Rose has assembled a mentoring team comprised of the following experts: Dr. Michael Snyder (primary mentor) is a leader in the field of personalized medicine who has established a unique cohort undergoing comprehensive, state-of-the-art, multiomics profiling with frequent longitudinal sampling. He provides access to this rich data repository as well as laboratory support for novel analyses. Dr. Mark Cullen is director of the Stanford Center for Population Health Sciences and leader of Stanford Precision Health for Ethnic and Racial Equity Center which focuses on using precision-medicine tools to improve the health of underserved ethnic and racial groups. Dr. Cullen brings considerable experience in integrating data on toxic exposures, psychosocial exposures and behavioral measures to understand how different aspects of the exposome act in combination to produce positive and negative outcomes. Dr. David Rehkopf is an expert in life course epidemiology and advanced longitudinal, nonlinear and spatial data analysis methods. Dr. Marc Feldman is an expert in complex systems and mathematical biology whose work in quantitative cultural evolution combines tools from multiple disciplines to understand the combined roles of culture and genes in shaping human evolution. Dr. George Slavich is an expert in stress assessment, social genomics and psychoneuroimmunology. The specific aims are as follows: Aim 1. Add a targeted assay for persistent organic chemicals (POCs) as a measure of POC exposure to the study and characterize relationship to the internal exposome, adversity and stress exposures. Aim 2. Evaluate the longitudinal trajectories of POCs and their covariation with clinical and omics measures. Aim 3. Integrate longitudinal multiomics data and multiple perturbation data to create a Complex Systems - Causal Network model to evaluate the joint effects of POCs and other exposures on impaired glucose regulation.

项目摘要/摘要 这是为SophiaMiryamSchüssler-Fiorenza Rose，医学博士，博士，物理医学和 脊髓损伤医学和人群健康科学家的康复医师。 她的长期目标是领导一个可以应用复杂系统方法和其他新颖的多学科研究团队 分析方法解决不良暴​​露对受影响的人的神经新闻和长期健康的影响 神经疾病和相关疾病。 该K08奖将为Rose博士提供实现以下教育目标所需的支持。 1。开发专业知识评估环境，社会心理和内部展示体。 2。发​​展评估方面的专业知识 使用纵向多次分析的暴露的生物学效应。 3。纵向发展高级技能 多组学数据分析，复杂系统和因果建模方法。 4。发展领导多学科的技能 研究团队。 5。发展翻译技能和设计研究，以验证临床研究的一些研究结果 或基于人群的样本，这将是她独立研究生涯的启动点。 为了实现这些目标，罗斯博士组建了一个心理团队，完成了以下专家：迈克尔·斯奈德博士 （主要导师）是个性化医学领域的领导者，他建立了一个独特的队列 综合，最先进的多组学分析，经常进行纵向采样。他提供了这种富人的机会 数据存储库以及实验室支持新分析。马克·库伦（Mark Cullen）博士是斯坦福大学中心主任 人口健康科学和斯坦福大学精密健康的领导者，专注于种族和种族平等中心 使用精密医师工具来改善服务不足的种族和种族群体的健康。库伦博士带来了很大的 在整合有关有毒暴露，社会心理暴露和行为措施的数据方面的经验，以了解如何 裸露行为的不同方面结合起来产生积极和负面结果。 David Rehkopf博士是 生命课程的专家流行病学以及高级纵向，非线性和空间数据分析方法。马克博士 费尔德曼（Feldman）是复杂系统和数学生物学的专家，其在定量文化进化组合中的工作 来自多个学科的工具，了解文化和基因在塑造人类进化中的综合作用。博士 乔治·斯拉维奇（George Slavich）是压力评估，社会基因组学和心理免疫学专家。 具体目的如下：目标1。添加持续有机化学（POC）的目标测定作为POC的量度 接触研究，并表征与内部暴露，广告和压力暴露的关系。目标2。评估 POC的纵向轨迹及其与临床和OMICS措施的协方差。目标3。整合纵向 多组学数据和多个扰动数据创建一个复杂的系统 - 因果网络模型，以评估关节 POC和其他暴露对葡萄糖调节受损的影响。