The Alzheimer's Disease Clinical and Translational Research (ADCTR) Training Program

这是针对阿尔茨海默病临床和转化研究 (ADCTR) 培训的新提案 伦斯勒理工学院 (RPI) 与蒙特伊坎医学院合作的项目 西奈半岛（ISMMS）。我们的目标是增加三所学校学生之间的互动 （建筑、工程和科学）和四个博士学位授予部门（生物医学工程、 生物科学、化学工程和化学）以及四个全研究所中心（中心 生物技术与跨学科研究（CBIS）、照明研究中心（LRC）、数据研究所 探索与应用（IDEA）和塞韦里诺技术创业中心）以及 RPI 计算机科学系和拉利管理学院。罗纳德·勒布中心 ISMMS 伊坎医学院的阿尔茨海默病和行业合作伙伴将提供短期治疗 AD 和 AD 相关痴呆症的培训/研究项目。该培训计划将为学员提供 对阿尔茨海默病研究的跨学科、临床和转化性质的敏锐理解 和相关的痴呆症，它如何依赖于科学和工程的基本基础，它如何 带来创新的新科学学科和技术，如何将其应用于临床环境，以及 商业产品是如何开发的。这些项目的教师积极参与研究 项目涵盖以下内容：1）针对阿尔茨海默病的药物和非药物干预 疾病和神经退行性疾病； 2）生物标志物和成像； 3）结构生物学 蛋白质折叠/tau。培训计划的关键方面将包括：[1] 一组四门课程，将 最大限度地加强关键学科的教学培训； [2] 题为“阿尔茨海默病的观点”的核心课程 所有学员都将参加的“疾病研究”课程； [3] 一系列研讨会和研究研讨会将建立 RPI 及其临床和行业合作伙伴的校园范围内的项目； [4] 学生举办的研讨会项目， 哪些学员向同行和培训教师展示他们的研究成果； [5] 负责任行为培训 研究； [6] 联合监督（每个学员至少有 2 名跨学科导师）和多学科 博士论文委员会成员建筑、科学和工程方面的论文工作； [7] 工业 和/或临床实习； [8] 海报展示及参加CBIS年会和 LRC行业合作伙伴计划； [9] 创业与商业翻译培训； [10] 每年 当代阿尔茨海默病和相关痴呆症研究的退却，受训者和其他人 在校园内与该领域的外部研究人员互动。执行委员会将确保学员 满足计划要求，代表性不足的少数族裔招聘 (URM) 委员会将积极 参与、识别和招募多元化的学生群体加入该计划。除了六个实习生名额之外 在此提议的每年，伦斯勒每年将支持两名学院实习生。

This is a new proposal for the Alzheimer's Disease Clinical and Translational Research (ADCTR) Training Program at Rensselaer Polytechnic Institute (RPI) in collaboration with the Icahn School of Medicine at Mount Sinai (ISMMS). Our objectives are aimed at increased interaction among students from the three schools (Architecture, Engineering and Science) and four PhD granting departments (Biomedical Engineering, Biological Sciences, Chemical Engineering and Chemistry) as well as four Institute-wide centers (Center for Biotechnology and Interdisciplinary Studies (CBIS), Lighting Research Center (LRC), Institute of Data Exploration and Application (IDEA) and Severino Center for Technological Entrepreneurship) as well as the Department of Computer Science and the Lally School of Management at RPI. The Ronald M. Loeb Center for Alzheimer's Disease at Icahn School of Medicine at ISMMS and industry partners will provide short term training/research projects in AD and AD-related dementias. This Training Program will provide trainees with a keen understanding of the interdisciplinary, clinical and translational nature of research on Alzheimer's disease and related dementias, how it depends on fundamental underpinnings of both science and engineering, how it leads to innovative new scientific disciplines and technologies, how it can be applied to clinical settings, and how commercial products are developed. Faculty from these programs are actively involved in research programs spanning the following: 1) pharmacologic and non-pharmacologic interventions for Alzheimer's disease and neurodegenerative disease; 2) biomarkers and imaging; and 3) structural biology of protein folding/tau. Key aspects of the training program will include: [1] a set of four courses that will maximize didactic training among the key disciplines; [2] a core course entitled “Perspectives in Alzheimer's Disease Research” that will be taken by all trainees; [3] a seminar series and research symposia that will build on campus-wide programs at RPI and its clinical and industry partners; [4] a student-run seminar program, in which trainees present their research to their peers and training faculty; [5] training in responsible conduct of research; [6] joint supervision (at least 2 mentors spanning disciplines per trainee) and a multidisciplinary thesis committee membership for Ph.D. thesis work in architecture, science and engineering; [7] industrial and/or clinical externships; [8] poster presentation and participation in the annual meeting of the CBIS and LRC Industry Partners Program; [9] entrepreneurship and commercial translation training; and [10] an annual retreat in contemporary research in Alzheimer's Disease and related dementias at which trainees and others on campus interact with outside researchers in the field. An Executive Committee will ensure that trainees satisfy Program requirements and an Underrepresented Minority Recruitment (URM) Committee will actively engage in, identify and recruit a diverse student population into the program. In addition to the six trainee slots per year proposed herein, Rensselaer will support two Institute trainees per year.