The Alzheimer's Disease Clinical and Translational Research (ADCTR) Training Program

阿尔茨海默病临床和转化研究 (ADCTR) 培训计划

• 批准号: 10221565
• 负责人: Chunyu Wang
• 金额: $ 30.36万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221565
• 关键词: Alzheimer' s Disease; Clinical Research; Training Programs; Translational Research

This is a new proposal for the Alzheimer's Disease Clinical and Translational Research (ADCTR) Training Program at Rensselaer Polytechnic Institute (RPI) in collaboration with the Icahn School of Medicine at Mount Sinai (ISMMS). Our objectives are aimed at increased interaction among students from the three schools (Architecture, Engineering and Science) and four PhD granting departments (Biomedical Engineering, Biological Sciences, Chemical Engineering and Chemistry) as well as four Institute-wide centers (Center for Biotechnology and Interdisciplinary Studies (CBIS), Lighting Research Center (LRC), Institute of Data Exploration and Application (IDEA) and Severino Center for Technological Entrepreneurship) as well as the Department of Computer Science and the Lally School of Management at RPI. The Ronald M. Loeb Center for Alzheimer's Disease at Icahn School of Medicine at ISMMS and industry partners will provide short term training/research projects in AD and AD-related dementias. This Training Program will provide trainees with a keen understanding of the interdisciplinary, clinical and translational nature of research on Alzheimer's disease and related dementias, how it depends on fundamental underpinnings of both science and engineering, how it leads to innovative new scientific disciplines and technologies, how it can be applied to clinical settings, and how commercial products are developed. Faculty from these programs are actively involved in research programs spanning the following: 1) pharmacologic and non-pharmacologic interventions for Alzheimer's disease and neurodegenerative disease; 2) biomarkers and imaging; and 3) structural biology of protein folding/tau. Key aspects of the training program will include: [1] a set of four courses that will maximize didactic training among the key disciplines; [2] a core course entitled “Perspectives in Alzheimer's Disease Research” that will be taken by all trainees; [3] a seminar series and research symposia that will build on campus-wide programs at RPI and its clinical and industry partners; [4] a student-run seminar program, in which trainees present their research to their peers and training faculty; [5] training in responsible conduct of research; [6] joint supervision (at least 2 mentors spanning disciplines per trainee) and a multidisciplinary thesis committee membership for Ph.D. thesis work in architecture, science and engineering; [7] industrial and/or clinical externships; [8] poster presentation and participation in the annual meeting of the CBIS and LRC Industry Partners Program; [9] entrepreneurship and commercial translation training; and [10] an annual retreat in contemporary research in Alzheimer's Disease and related dementias at which trainees and others on campus interact with outside researchers in the field. An Executive Committee will ensure that trainees satisfy Program requirements and an Underrepresented Minority Recruitment (URM) Committee will actively engage in, identify and recruit a diverse student population into the program. In addition to the six trainee slots per year proposed herein, Rensselaer will support two Institute trainees per year.

这是对阿尔茨海默病临床和翻译研究(ADCTR)培训的新建议 伦斯勒理工学院(RPI)与蒙特伊坎医学院合作的项目 西奈半岛(ISMMS)。我们的目标是加强三所学校学生之间的互动。 (建筑、工程和科学)和四个博士授予系(生物医学工程， 生物科学、化学工程和化学)以及四个研究所范围的中心( 生物技术和跨学科研究(CBIS)，照明研究中心(LRC)，数据研究所 探索和应用(IDEA)和塞维里诺技术创业中心)以及 RPI计算机科学系和拉利管理学院。罗纳德·M·勒布中心 ISMMS伊坎医学院的阿尔茨海默氏症和行业合作伙伴将提供短期 AD和AD相关痴呆的培训/研究项目。本培训计划将为学员提供 对阿尔茨海默病研究的跨学科、临床和翻译性质有深刻的理解 以及相关的痴呆症，它如何依赖于科学和工程的基本基础，它如何 导致创新的新科学学科和技术，如何将其应用于临床环境，以及 商业产品是如何开发的。这些项目的教员积极参与研究。 涵盖以下方案：1)阿尔茨海默氏症的药理学和非药理学干预 疾病和神经退行性疾病；2)生物标志物和成像；以及3)结构生物学 蛋白质折叠/tau。培训计划的主要方面将包括：[1]一套四门课程，将 最大限度地在关键学科中进行教学培训；[2]一门名为“阿尔茨海默氏病的观点”的核心课程 疾病研究“，将由所有受训者参加；[3]一系列研讨会和研究专题讨论会，将建立 在RPI及其临床和行业合作伙伴的校园范围内的计划；[4]学生运营的研讨会计划， 哪些受训者向他们的同行和培训教师展示他们的研究成果；[5]负责任的行为培训 研究；[6]联合监督(每个学员至少有2名跨学科的导师)和一个多学科 建筑、科学和工程领域博士论文工作的论文委员会成员；[7]工业 和/或临床外展；[8]海报展示和参加CBIS年会和 LRC行业合作伙伴计划；[9]创业和商务翻译培训；以及[10]年度 受训者和其他人在阿尔茨海默病和相关痴呆方面的当代研究进展 在校园里，与该领域的外部研究人员互动。执行委员会将确保受训人员 满足计划要求和代表不足的少数民族招募(URM)委员会将积极 参与、识别和招募不同的学生群体加入该计划。除了六个实习生名额外 在此建议的每一年，伦斯勒将每年支持两名学院实习生。