Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and Biology

数据科学、工程和生物学交叉领域的阿尔茨海默病博士前培训项目

• 批准号: 10628106
• 负责人: Chunyu Wang
• 金额: $ 24.08万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628106
• 关键词: Alzheimer' s Disease; Biology; Data Science; Engineering; Training Programs; pre-doctoral

Project Summary/Abstract The overarching goal of this Training Program for predoctoral students based at the at the Rensselaer Polytechnic Institute (RPI) is to provide cross-disciplinary training for future innovative leaders in translational ADRD research. Our training will emphasize the application of data science and engineering principles to ADRD biology and translational research through interdisciplinary research projects and coursework. The proposed Training Program will provide trainees with a keen understanding of the interdisciplinary and translational nature of ADRD research, which is firmly based on fundamental research in biological sciences, data science and engineering, leading to innovative new scientific disciplines and technologies, novel AD drug development, and translation of discoveries to the clinic. Training faculty are actively involved in research programs spanning: 1) data science as applied to ADRD, including medical imaging; 2) pharmacologic interventions for ADRD; and 3) structural biology of protein folding/tau. The Alzheimer’s Disease Research Center (ADRC) at Icahn School of Medicine at Mount Sinai (ISMMS) will be our clinical training partner through a subcontract and will provide ample access to educational and research opportunities to our trainees. Key aspects of the Training Program include: [1] a set of five courses to maximize didactic training among the key disciplines, including a new course entitled “Data Science and ADRD” and summer bootcamp “Data Science and ADRD: Hands-on Training and Research Challenge”. Development and launch of the new data science course and summer bootcamp have been funded by a supplement to the current NIA T32, with their inaugural runs planned for 2022; [2] a core course entitled “Perspectives in Alzheimer’s Disease Research” that is taken by all trainees and open to other RPI students; [3] a seminar series (Frontiers in Alzheimer’s Research) and related research symposia that builds on campus-wide programs at RPI and clinical and industry partners; [4] a student-run seminar program, in which trainees present their research to their peers and training faculty; [5] training in responsible conduct of research; [6] Co-advising and multidisciplinary PhD thesis committee with ADRD expertise; [7] translational and clinical internship at Icahn School of Medicine at Mount Sinai (ISMMS) and industrial partners; [8] poster presentation and participation at annual meetings of the Rensselaer Center for Biotechnology and Interdisciplinary Studies (CBIS) and Institute for Data Exploration and Applications (IDEA); [9] entrepreneurship and commercial translation training; and [10] an annual retreat in contemporary research in AD and related dementias at which trainees and members of the larger campus community interact with prominent researchers in the field.

项目摘要/摘要 伦斯勒大学博士前培训项目的总体目标是 理工学院(RPI)将为未来的翻译创新领导者提供跨学科培训 ADRD研究。我们的培训将强调将数据科学和工程原理应用于 ADRD通过跨学科研究项目和课程工作进行生物学和翻译研究。这个 拟议的培训计划将为学员提供对跨学科和 ADRD研究的翻译性，它牢固地以生物科学的基础研究为基础， 数据科学与工程，引领创新的科学学科和技术，AD新药 开发，并将发现转化为临床。培训教师积极参与研究工作 课程范围：1)应用于ADRD的数据科学，包括医学成像；2)药理学 对ADRD的干预；3)蛋白质折叠/tau的结构生物学。阿尔茨海默病的研究进展 西奈山伊坎医学院(ISMMS)的临床培训中心(ADRC)将通过 这是一份分包合同，将为我们的学员提供充足的教育和研究机会。钥匙 培训计划的方面包括：[1]一套五门课程，以最大限度地发挥教学培训的关键作用 学科，包括名为《数据科学与ADRD》的新课程和《数据科学》夏令营 和ADRD：实践培训和研究挑战“。新数据科学的发展和推出 课程和夏令营是由目前的NIA T32的一个补充提供资金的，这是他们的第一个 计划在2022年举办；[2]将开设一门名为《阿尔茨海默病研究展望》的核心课程 由所有受训人员提供，并向RPI的其他学生开放；[3]系列研讨会(阿尔茨海默氏症研究前沿)和 以RPI、临床和行业合作伙伴的校园计划为基础的相关研究座谈会；[4]a 学生开办的研讨会计划，受训者向他们的同龄人和培训教师展示他们的研究； 负责任地进行研究方面的培训；[6]联合咨询和多学科博士论文委员会 ADRD专业知识；[7]在西奈山伊坎医学院(ISMMS)的翻译和临床实习 和工业合作伙伴；[8]海报展示和参加伦斯勒中心年会 生物技术和跨学科研究(CBIS)和数据探索与应用研究所 (想法)；[9]创业和商务翻译培训；以及[10]当代企业年度务虚会 对受训者和更大校园社区成员互动的AD和相关痴呆的研究 与该领域的知名研究人员合作。