Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and Biology

数据科学、工程和生物学交叉领域的阿尔茨海默病博士前培训项目

• 批准号: 10628106
• 负责人: Chunyu Wang
• 金额: $ 24.08万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628106
• 关键词: Alzheimer' s Disease; Biology; Data Science; Engineering; Training Programs; pre-doctoral

Project Summary/Abstract The overarching goal of this Training Program for predoctoral students based at the at the Rensselaer Polytechnic Institute (RPI) is to provide cross-disciplinary training for future innovative leaders in translational ADRD research. Our training will emphasize the application of data science and engineering principles to ADRD biology and translational research through interdisciplinary research projects and coursework. The proposed Training Program will provide trainees with a keen understanding of the interdisciplinary and translational nature of ADRD research, which is firmly based on fundamental research in biological sciences, data science and engineering, leading to innovative new scientific disciplines and technologies, novel AD drug development, and translation of discoveries to the clinic. Training faculty are actively involved in research programs spanning: 1) data science as applied to ADRD, including medical imaging; 2) pharmacologic interventions for ADRD; and 3) structural biology of protein folding/tau. The Alzheimer’s Disease Research Center (ADRC) at Icahn School of Medicine at Mount Sinai (ISMMS) will be our clinical training partner through a subcontract and will provide ample access to educational and research opportunities to our trainees. Key aspects of the Training Program include: [1] a set of five courses to maximize didactic training among the key disciplines, including a new course entitled “Data Science and ADRD” and summer bootcamp “Data Science and ADRD: Hands-on Training and Research Challenge”. Development and launch of the new data science course and summer bootcamp have been funded by a supplement to the current NIA T32, with their inaugural runs planned for 2022; [2] a core course entitled “Perspectives in Alzheimer’s Disease Research” that is taken by all trainees and open to other RPI students; [3] a seminar series (Frontiers in Alzheimer’s Research) and related research symposia that builds on campus-wide programs at RPI and clinical and industry partners; [4] a student-run seminar program, in which trainees present their research to their peers and training faculty; [5] training in responsible conduct of research; [6] Co-advising and multidisciplinary PhD thesis committee with ADRD expertise; [7] translational and clinical internship at Icahn School of Medicine at Mount Sinai (ISMMS) and industrial partners; [8] poster presentation and participation at annual meetings of the Rensselaer Center for Biotechnology and Interdisciplinary Studies (CBIS) and Institute for Data Exploration and Applications (IDEA); [9] entrepreneurship and commercial translation training; and [10] an annual retreat in contemporary research in AD and related dementias at which trainees and members of the larger campus community interact with prominent researchers in the field.

项目总结/摘要 该培训计划的首要目标是为在伦斯勒大学的博士前学生提供培训， 理工学院（RPI）是为未来的创新领导者提供跨学科的培训， ADRD研究。我们的培训将强调数据科学和工程原理的应用， 通过跨学科研究项目和课程进行ADRD生物学和转化研究。的 拟议的培训计划将为学员提供对跨学科和跨领域的敏锐理解 ADRD研究的转化性质，牢固地建立在生物科学基础研究的基础上， 数据科学与工程，引领创新的新科学学科和技术，新型AD药物 开发，并将发现转化为临床。培训教师积极参与研究 项目涵盖：1）应用于ADRD的数据科学，包括医学成像; 2）药理学 ADRD的干预;和3）蛋白质折叠/tau的结构生物学。老年痴呆症的研究 西奈山伊坎医学院（ISMMS）的ADRC中心将成为我们的临床培训合作伙伴， 我们的培训计划将为学员提供充足的教育和研究机会。关键 培训计划的方面包括：[1]一套五门课程，以最大限度地提高教学培训的关键， 学科，包括一个名为“数据科学和ADRD”的新课程和夏令营“数据科学” 和ADRD：实践培训和研究挑战”。开发和推出新的数据科学 课程和夏季训练营已经由目前的NIA T32的补充资助，他们的就职典礼 计划于2022年运行; [2]一个名为“阿尔茨海默病研究的观点”的核心课程， 由所有学员和开放给其他RPI学生; [3]一个研讨会系列（前沿在阿尔茨海默氏症的研究）和 相关的研究座谈会，建立在校园范围内的计划在RPI和临床和行业合作伙伴; [4] 学生管理的研讨会项目，学员向同行和培训教师展示他们的研究; [5] 负责的研究行为的培训; [6]共同咨询和多学科博士论文委员会， ADRD专业知识; [7]西奈山伊坎医学院（ISMMS）的翻译和临床实习 和工业合作伙伴; [8]伦斯勒中心年会上的海报展示和参与 生物技术和跨学科研究（CBIS）和数据探索和应用研究所 [9]创业和商业翻译培训;[10]当代艺术的年度务虚会 在AD和相关痴呆症的研究，学员和更大的校园社区的成员互动 与该领域的杰出研究人员进行交流。