San Antonio Claude D. Pepper Older Americans Independence Center

圣安东尼奥克劳德·D·佩珀美国老年人独立中心

• 批准号: 10221552
• 负责人: Sara Elyse Espinoza
• 金额: $ 135.31万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10221552
• 关键词: Aging; Alzheimer' s disease pathology; American; Awareness; Behavior Therapy; Biology of Aging; Biometry; Callithrix; Capsicum; Cell Aging; Chronic Disease; Clinical; Clinical Pharmacology; Clinical Research; Clinical Trials; Clinical Trials Design; Cognitive; Communities; Custom; Development; Diamond; Disease; Education; Elderly; Epigenetic Process; Exercise; Foundations; Funding; GDF8 gene; Gerontology; Geroscience; Goals; Grant; Human; Immune; Inflammation; Informatics; Infrastructure; Institutes; Institution; Intervention; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Longevity; Maintenance; Mediator of activation protein; Medication Management; Metabolic dysfunction; Metformin; Methylene blue; Mitochondria; Modeling; Monkeys; Oxytocin; Patients; Pharmacology; Phase; Pilot Projects; Play; Principal Investigator; Process; Research; Research Design; Research Personnel; Research Support; Resources; Scientist; Series; Services; Shock; Sirolimus; Site; Testing; Training; Translating; base; bench to bedside; clinical center; cohesion; data management; disability; drug development; dysbiosis; education research; exhaustion; first-in-human; frailty; gut microbiome; healthspan; healthy aging; human disease; improved; innovation; knowledge base; lifestyle intervention; mTOR Inhibitor; meetings; microbiome; mild cognitive impairment; multidisciplinary; nonhuman primate; nutrition; operation; oral microbiome; pre-clinical research; programs; recruit; sarcopenia; square foot; stem cells; stress reduction; symposium; trial design; web site

A core tenet of the geroscience concept is that multiple human diseases arise from aging itself. Thus, the central theme of the San Antonio (SA) Claude D. Pepper Older Americans Independence Center (OAIC) is translational geroscience – moving research on the basic biology of aging from the laboratory bench to the clinic, with the overarching goal of promoting healthy aging and developing desperately needed treatments, mainly pharmacological, for aging-related diseases. This goal is achieved through the following Aims: 1) Expand the knowledge base in translational geroscience by catalyzing transformative research; 2) Create a cadre of multidisciplinary early-stage investigators with customized expertise in translational geroscience; 3) Serve as a resource and partner to investigators from other OAICs and institutions; and 4) Provide intellectual leadership, disseminate knowledge, and stimulate discussion on translational geroscience-related themes. The SA OAIC achieves these Aims through a Leadership and Administrative Core (LAC) that directs operations and sponsors several enrichment and dissemination activities; a Pilot and Exploratory Studies Core (PESC) that provides merit-based support for rigorously designed studies; a Research Education Component (REC) that expands a greatly needed cadre of uniquely qualified scientists cross-trained in aging biology and translational geroscience; a Pre-Clinical Research Core (RC1) which supports research in marmoset monkeys; a Clinical Research and Pharmacology Core (RC2) that delivers comprehensive trial support for recruitment/retention, assessments, pharmacology, and data management; and a Trial Design and Integrative Informatics Core (RC3) that provides comprehensive study design, biostatistics and informatics services. During the ~4 years since its funding, the SA OAIC supported 46 PIs, performing transformative translational geroscience-focused research in essentially all pillars/hallmarks of aging. For example, RC1 is conducting the only known lifespan and healthspan study on mTOR inhibitors in nonhuman primates. RC2 and RC3 carried out the first trial on rapamycin to examine immune and cognitive effects in healthy older adults and performed the first-in-man studies on senolytics. The OAIC supported 10 Scholars who are making transformative discoveries (e.g. first demonstration of cellular senescence as a key mediator of Alzheimer's pathology) and receiving highly competitive career development awards from the NIA/AFAR (Beeson, Irene Diamond) and the VA. The SA OAIC is built on a unique foundation provided by UTHSCSA's exceptional and tightly integrated resources: a Nathan Shock Center, a site of the Interventions Testing Program (ITP), a GRECC, a T32 Training Grant on Geroscience, and a robust Barshop Institute that unites aging research at UTHSCSA. We are the only OAIC with all of these synergistic components available. In addition, the SA OAIC receives unparalleled institutional commitment (~$600,000/year), including a new ~$100M 109,000 sq. ft. building – specific for the Barshop Institute – that will house the OAIC, Shock Center, and the ITP in a centrally located facility.

老年科学概念的一个核心原则是，多种人类疾病是由衰老本身引起的。因此 中心主题的圣安东尼奥（SA）克劳德D.胡椒老年美国人独立中心（OAIC） 是转化老年科学-移动研究的基础生物学老化从实验室工作台， 诊所，其总体目标是促进健康老龄化和开发迫切需要的治疗， 主要是药理学的，用于与衰老有关的疾病。这一目标是通过以下目标实现的： 1)通过催化变革性研究扩大翻译老年科学的知识基础; 2）创建 一批多学科的早期研究人员，他们具有翻译老年科学方面的定制专业知识; 3） 作为其他OAIC和机构调查人员的资源和合作伙伴;以及4）提供知识 领导力、传播知识并激发对转化老年科学相关主题的讨论。 SA OAIC通过领导和管理核心（LAC）实现这些目标， 业务和赞助一些丰富和传播活动;试点和探索性研究核心 （PESC）为严格设计的研究提供基于绩效的支持;研究教育组件 (REC)这扩大了一个非常需要的独特的合格的科学家在老化生物学交叉训练的干部， 转化老年科学;临床前研究核心（RC 1），支持在绒猴研究; 临床研究和药理学核心（RC 2），为以下方面提供全面的试验支持： 招募/保留、评估、药理学和数据管理;以及试验设计和整合 信息学核心（RC 3），提供全面的研究设计，生物统计学和信息学服务。 自资助以来的约4年内，SA OAIC支持了46名PI，进行了变革性的翻译 以老年科学为重点的研究，基本上涉及衰老的所有支柱/标志。例如，RC 1正在执行 在非人灵长类动物中进行的关于mTOR抑制剂的唯一已知寿命和健康跨度研究。RC 2和RC 3执行 第一次对雷帕霉素进行试验，以检查健康老年人的免疫和认知效果， 第一次对人体进行的老年医学研究OAIC支持了10位正在进行变革性发现的学者 (e.g.第一次证明细胞衰老是阿尔茨海默病病理学的关键介质）， 从NIA/AFAR（比森，艾琳钻石）和VA竞争职业发展奖。 该SA OAIC是建立在UTHSCSA的特殊和紧密集成提供了一个独特的基础， 资源：内森休克中心，干预测试计划（ITP）的网站，GRECC，T32培训 授予老年科学，和一个强大的Barshop研究所，团结在UTHSCSA老化研究。我们是唯一的 OAIC与所有这些协同组件可用。此外，SA OAIC获得了无与伦比的 机构承诺（约600，000美元/年），包括新的约1亿美元109，000平方米英尺建筑物专用的 巴肖普研究所-这将容纳OAIC，休克中心，和ITP在一个中心位置的设施。