Metformin for Preventing Frailty in High-risk Older Adults.

二甲双胍用于预防高危老年人的虚弱。

• 批准号: 10182059
• 负责人: Sara Elyse Espinoza
• 金额: $ 9.88万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10182059
• 关键词: Adult; Affect; Aging; Award; Beta Cell; Biological Markers; Cell physiology; Cessation of life; Characteristics; Clinical; Clinical Investigator; Clinical Trials; Cohort Studies; Data; Deterioration; Development; Diabetes Mellitus; Elderly; Endocrinologist; Enrollment; Etiology; Fatty acid glycerol esters; Foundations; Future; Gait speed; Glucose Intolerance; Goals; Hand Strength; Health; Hyperglycemia; Incidence; Individual; Inflammation; Inflammatory; Insulin Resistance; Intervention; Lead; Light; Link; Lipids; Longitudinal cohort; Metabolic dysfunction; Metformin; Non-Insulin-Dependent Diabetes Mellitus; Nursing Homes; Obesity; Parents; Patients; Physical activity; Play; Population; Prediabetes syndrome; Prevention; Research; Risk; Risk Factors; Role; Sampling; Syndrome; Testing; Thinness; Time; Triglycerides; United States Department of Veterans Affairs; Veterans; Work; adipokines; age related; blood glucose regulation; career development; clinical database; cytokine; diabetes risk; disability; frailty; high risk; impaired glucose tolerance; improved; insulin sensitivity; middle age; parent grant; pragmatic trial; prevent; prospective; sarcopenia

The purpose of this Research Supplement to Promote Diversity in Health-Related Research is to understand the factors that lead to onset of diabetes and frailty and to determine the temporal relationship between frailty and diabetes incidence in older adults. This research will also support the career development of Tiffany Cortes, MD, an endocrinologist and clinical investigator working with the PI of the parent trial (Espinoza). For this study, we will take advantage of the ongoing clinical trial where we are examining older, non-frail prediabetic patients over two years to test whether increased insulin sensitivity with metformin alters frailty onset. We will also conduct a larger cohort study in order to examine the incidence of diabetes and frailty in older adults using Veterans Administration (VA) clinical/administrative data. Briefly, our specific aims are: (1) Identify factors that increase the risk of conversion from prediabetes to diabetes, and predictors of diabetes and frailty in our prospective clinical trial. (2) Examine factors related to the onset of diabetes and frailty in an older veteran population. By accomplishing these aims, this study will shed light on risk factors for frailty and diabetes onset in older adults and the temporal relationship of these. This data will also provide the foundation for a future larger pragmatic study focused on prevention of frailty in older adults.

本研究增刊旨在促进健康相关研究的多样性，其目的是了解 导致糖尿病和虚弱发作的因素，并确定虚弱和虚弱之间的时间关系 老年人糖尿病发病率。这项研究还将支持医学博士 Tiffany Cortes 的职业发展， 与母试验 (Espinoza) 的 PI 合作的内分泌学家和临床研究者。对于这项研究，我们 将利用正在进行的临床试验，我们正在检查老年、非虚弱的糖尿病前期患者 两年来测试二甲双胍增加的胰岛素敏感性是否会改变虚弱的发生。我们还将举办一次 更大规模的队列研究，旨在利用退伍军人检查老年人糖尿病和虚弱的发病率 管理 (VA) 临床/管理数据。 简而言之，我们的具体目标是： (1) 确定增加从糖尿病前期转变为糖尿病的风险的因素以及糖尿病的预测因素 以及我们前瞻性临床试验中的脆弱性。 (2) 检查与老年退伍军人群体中糖尿病发病和虚弱相关的因素。 通过实现这些目标，这项研究将揭示老年人虚弱和糖尿病发病的危险因素 以及它们之间的时间关系。这些数据也将为未来更大规模的务实合作奠定基础。 研究重点是预防老年人的虚弱。