ADRD Prevention Messaging to Increase Smoking Cessation Attempts in Older Adult Smokers

ADRD 预防信息可增加老年吸烟者的戒烟尝试

• 批准号: 10398196
• 负责人: Adrienne L. Johnson
• 金额: $ 16.73万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398196
• 关键词: Abstinence; Accounting; Address; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Belief; Cause of Death; Cessation of life; Cholesterol; Clinic; Clinical; Clinical Trials; Communities; Counseling; Dementia; Development; Diabetes Mellitus; Disease; Distress; Doctor of Philosophy; Effectiveness; Elderly; Ensure; Etiology; Female; Fright; Future; Genetic Risk; Goals; Grant; Health; Health Professional; Health behavior change; Healthcare Systems; Heart Diseases; Hypertension; Impaired cognition; Incidence; Institute of Medicine (U.S.); Intervention; Life; Life Style Modification; Link; Literature; Marketing; Medical; Mentors; Methodology; Modeling; Motivation; Pathology; Patients; Personal Satisfaction; Persons; Pharmacotherapy; Population; Prevalence; Prevention; Primary Health Care; Psychologist; Public Health; Qualitative Methods; Reach Effectiveness Adoption Implementation and Maintenance; Research; Research Personnel; Resources; Risk; Risk Factors; Route; Severities; Smoker; Smoking; Smoking Cessation Intervention; Stroke; Subgroup; Survey Methodology; Surveys; Testing; Time; Tobacco Dependence; Training; Translations; Treatment Efficacy; Uncertainty; Underserved Population; Work; World Health Organization; age related; aging population; apprenticeship; brain health; career development; cigarette smoking; comorbidity; cost; cost estimate; dementia risk; design; disability; dissemination science; effective intervention; epidemiology study; evidence base; experience; feasibility trial; health belief; health care settings; healthy lifestyle; high risk; implementation framework; implementation science; improved; low socioeconomic status; modifiable risk; motivational intervention; novel; patient oriented; patient oriented research; prevent; prospective; public health priorities; rapid growth; smoking cessation; success; symposium; therapy design; therapy development; treatment as usual; treatment comparison; young adult

PROJECT SUMMARY/ABSTRACT This career development proposal resubmission is designed to provide Adrienne Johnson, PhD, the training necessary to become an independent investigator in the fields of tobacco dependence, Alzheimer’s disease and related dementias (ADRD), and dissemination and implementation (D&I) science. Dr. Johnson is trained as a clinical psychologist and has substantial experience with patient-oriented research in comorbid medical and psychiatric populations and expertise in smoking cessation within these populations. An expert mentoring team will guide her in achieving four training objectives: (1) develop a comprehensive understanding of ADRD etiological factors, prevention literature, and treatment approaches; (2) develop expertise in D&I science and its application to intervention development and testing; (3) develop expertise in public health marketing and motivational messaging; and (4) obtain training in larger scale clinical trial methodology. This training, consisting of formal coursework, guided mentoring, an apprenticeship, and participation in national scientific conferences, will allow Dr. Johnson to develop and test an intervention designed to help motivate older smokers quitting smoking. Older adult smokers are at elevated risk for cognitive decline and ADRD development and, unless they can successfully quit smoking, their prevalence will continue to rise. Unfortunately, older smokers are half as likely to attempt to quit smoking and less likely to receive evidence-based smoking treatments (EBSTs) compared to younger adults. Lower cessation efforts in older smokers may be a function of both clinician inaction and dysfunctional beliefs/motivational deficits of older smokers. The proposed work will develop and test a readily translatable Stage 1 motivational intervention for smoking cessation in older adults consisting of: (1) a novel patient-informed motivational message promoting smoking cessation, and (2) clear access routes to EBSTs within a healthcare setting. The proposed research will use three interrelated aims, occurring consecutively and building off of findings from the previous aim, to achieve this objective. Aim 1 will identify the most promising message content in terms of smoking cessation motivation and efficacy of and access to EBSTs in a healthcare setting. Aim 2 will evaluate promising motivational intervention packages using survey methodology. Finally, Aim 3 will examine the feasibility and preliminary effectiveness of a novel comprehensive motivational intervention to increase motivation to quit, quit attempts, and use of EBSTs for older adult smokers in a real-world clinical setting. Dr. Johnson will apply a widely used model of health behavior change (Health Belief Model) to guide treatment development and use a well validated D&I science framework (RE-AIM) to ensure she is building for translation. Results will inform a future R01 application aimed at implementing and evaluating this intervention in a broader context and examining the relation between smoking cessation and brain health.

项目概要/摘要 重新提交此职业发展提案旨在为 Adrienne Johnson 博士提供培训 有必要成为烟草依赖、阿尔茨海默氏病和 相关痴呆症（ADRD）以及传播和实施（D&I）科学。约翰逊博士接受过培训 临床心理学家，在共病医学和以患者为导向的研究方面拥有丰富的经验 精神病人群以及这些人群中戒烟的专业知识。专家辅导团队 将指导她实现四个培训目标：（1）全面了解 ADRD 病因、预防文献和治疗方法； (2) 发展 D&I 科学及其相关专业知识 应用于干预开发和测试； (3) 发展公共卫生营销方面的专业知识和 激励性信息； (4) 获得更大规模临床试验方法的培训。此次培训，包括 正式课程、指导性指导、学徒期以及参加国家科学会议， 将使约翰逊博士能够开发和测试旨在帮助激励老年吸烟者戒烟的干预措施 吸烟。老年吸烟者认知能力下降和 ADRD 发展的风险较高，除非他们 如果能够成功戒烟，其患病率将会持续上升。不幸的是，老年吸烟者的一半 可能尝试戒烟并且不太可能接受循证吸烟治疗 (EBST) 与年轻人相比。老年吸烟者戒烟努力较低可能是临床医生不作为的结果 以及老年吸烟者的功能失调的信念/动机缺陷。拟议的工作将开发和测试一个容易 针对老年人戒烟的可翻译第一阶段动机干预包括：(1) 一部小说 患者知情的激励信息促进戒烟，以及 (2) 获得 EBST 的明确途径 在医疗保健环境内。拟议的研究将使用三个相互关联的目标，连续发生和 以先前目标的发现为基础，实现这一目标。目标 1 将确定最有前途的 医疗保健中戒烟动机、EBST 功效和获取途径方面的消息内容 环境。目标 2 将使用调查方法评估有前景的激励干预方案。最后，瞄准 3将检验一种新颖的综合动机干预的可行性和初步有效性 在现实临床环境中提高老年吸烟者的戒烟动机、戒烟尝试和 EBST 的使用。 约翰逊博士将应用广泛使用的健康行为改变模型（健康信念模型）来指导治疗 开发并使用经过充分验证的 D&I 科学框架 (RE-AIM)，以确保她正在为翻译而构建。 结果将为未来的 R01 应用提供信息，该应用旨在在更广泛的范围内实施和评估该干预措施 背景并检查戒烟与大脑健康之间的关系。