ADRD Prevention Messaging to Increase Smoking Cessation Attempts in Older Adult Smokers

ADRD 预防信息可增加老年吸烟者的戒烟尝试

• 批准号: 10586090
• 负责人: Adrienne L. Johnson
• 金额: $ 16.73万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586090
• 关键词: Abstinence; Acceleration; Accounting; Address; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Articulation; Belief; Cause of Death; Cessation of life; Cholesterol; Clinical; Clinical Trials; Communities; Counseling; Dementia; Development; Diabetes Mellitus; Disease; Distress; Doctor of Philosophy; Effectiveness; Elderly; Ensure; Etiology; Female; Fright; Future; Genetic Risk; Goals; Grant; Health; Health Professional; Health behavior change; Healthcare Systems; Heart Diseases; Hypertension; Impaired cognition; Incidence; Institute of Medicine (U.S.); Intervention; Life; Life Style Modification; Link; Literature; Marketing; Medical; Mentors; Methodology; Modeling; Motivation; Pathology; Patients; Personal Satisfaction; Persons; Pharmacotherapy; Population; Prevalence; Prevention; Psychologist; Public Health; Qualitative Methods; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Personnel; Resources; Risk; Risk Factors; Route; Severities; Smoker; Smoking; Smoking Cessation Intervention; Smoking treatment; Stroke; Subgroup; Survey Methodology; Surveys; Testing; Time; Tobacco Dependence; Training; Translations; Treatment Efficacy; Uncertainty; Underserved Population; Work; World Health Organization; age related; aging population; apprenticeship; brain health; career development; cigarette smoking; comorbidity; cost; cost estimate; dementia risk; design; disability; dissemination science; effective intervention; epidemiology study; evidence base; experience; feasibility trial; health belief; health care settings; healthy lifestyle; high risk; implementation framework; implementation science; improved; low socioeconomic status; modifiable risk; motivational intervention; novel; patient oriented; patient oriented research; prevent; primary care clinic; prospective; public health priorities; rapid growth; smoking cessation; success; symposium; therapy design; therapy development; treatment as usual; treatment comparison; young adult

PROJECT SUMMARY/ABSTRACT This career development proposal resubmission is designed to provide Adrienne Johnson, PhD, the training necessary to become an independent investigator in the fields of tobacco dependence, Alzheimer’s disease and related dementias (ADRD), and dissemination and implementation (D&I) science. Dr. Johnson is trained as a clinical psychologist and has substantial experience with patient-oriented research in comorbid medical and psychiatric populations and expertise in smoking cessation within these populations. An expert mentoring team will guide her in achieving four training objectives: (1) develop a comprehensive understanding of ADRD etiological factors, prevention literature, and treatment approaches; (2) develop expertise in D&I science and its application to intervention development and testing; (3) develop expertise in public health marketing and motivational messaging; and (4) obtain training in larger scale clinical trial methodology. This training, consisting of formal coursework, guided mentoring, an apprenticeship, and participation in national scientific conferences, will allow Dr. Johnson to develop and test an intervention designed to help motivate older smokers quitting smoking. Older adult smokers are at elevated risk for cognitive decline and ADRD development and, unless they can successfully quit smoking, their prevalence will continue to rise. Unfortunately, older smokers are half as likely to attempt to quit smoking and less likely to receive evidence-based smoking treatments (EBSTs) compared to younger adults. Lower cessation efforts in older smokers may be a function of both clinician inaction and dysfunctional beliefs/motivational deficits of older smokers. The proposed work will develop and test a readily translatable Stage 1 motivational intervention for smoking cessation in older adults consisting of: (1) a novel patient-informed motivational message promoting smoking cessation, and (2) clear access routes to EBSTs within a healthcare setting. The proposed research will use three interrelated aims, occurring consecutively and building off of findings from the previous aim, to achieve this objective. Aim 1 will identify the most promising message content in terms of smoking cessation motivation and efficacy of and access to EBSTs in a healthcare setting. Aim 2 will evaluate promising motivational intervention packages using survey methodology. Finally, Aim 3 will examine the feasibility and preliminary effectiveness of a novel comprehensive motivational intervention to increase motivation to quit, quit attempts, and use of EBSTs for older adult smokers in a real-world clinical setting. Dr. Johnson will apply a widely used model of health behavior change (Health Belief Model) to guide treatment development and use a well validated D&I science framework (RE-AIM) to ensure she is building for translation. Results will inform a future R01 application aimed at implementing and evaluating this intervention in a broader context and examining the relation between smoking cessation and brain health.

项目摘要/摘要 该职业发展建议重新提交旨在为培训提供Adrienne Johnson博士 成为烟草依赖，阿尔茨海默氏病和 相关痴呆症（ADRD）以及传播与实施（D＆I）科学。约翰逊博士被培训为 临床心理学家，并在以患者为导向的研究中具有丰富的经验 这些人群中的精神病学和戒烟方面的专业知识。专家心理团队 将指导她实现四个培训目标：（1）对ADRD建立全面的了解 病因学因素，预防文献和治疗方法； （2）发展D＆I科学及其ITS的专业知识 应用干预开发和测试； （3）发展公共卫生营销方面的专业知识和 激励性消息传递； （4）获得大规模临床试验方法的培训。这项培训，包括 正式的课程工作，指导性的心理，学徒制和参加民族科学会议， 将允许约翰逊博士开发和测试一种旨在帮助激励老年吸烟者安静的干预措施 吸烟。老年吸烟者的认知能力下降和ADRD发展的风险较高，除非他们 可以成功戒烟，他们的患病率将继续上升。不幸的是，年长的吸烟者是一半 可能试图戒烟，并且不太可能接受循证吸烟治疗（EBSTS） 与年轻人相比。较老的吸烟者的停止工作可能是两种临床无所作部的函数 和功能失调的信念/动机定义了老年吸烟者。拟议的工作将很容易开发和测试 可翻译的第1阶段的动机干预措施在老年人中戒烟，包括：（1）新小说 患者信息促进戒烟的动机信息，以及（2）通往EBSTS的清除访问路线 在医疗保健环境中。拟议的研究将使用三个相互关联的目标，不断发生 基于以前目标的发现，以实现这一目标。 AIM 1将确定最有前途的 在戒烟动机和效率方面的消息内容以及在医疗保健中获得EBSTS的信息 环境。 AIM 2将使用调查方法评估有希望的动机干预套件。最后，瞄准 3将研究新颖的全面动机干预措施的可行性和初步效果 在现实世界中，增加了戒烟，退出尝试和使用EBST的动力。 约翰逊博士将采用广泛使用的健康行为改变模型（健康信念模型）来指导治疗 开发和使用经过良好验证的D＆I科学框架（RE-AIM）来确保她正在构建翻译。 结果将为未来的R01应用程序提供旨在实施和评估此干预措施的应用程序 背景并检查戒烟与大脑健康之间的关系。