Microbiome Function in Atopic Dermatitis
微生物组在特应性皮炎中的功能
基本信息
- 批准号:10397579
- 负责人:
- 金额:$ 47.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:18 year old6 year oldAdultAgeAnti-Inflammatory AgentsAntibiotic ResistanceAntibioticsAntigen-Presenting CellsAtopic DermatitisBacteriaCellsCharacteristicsChildChildhoodChronicChronic DiseaseClinical ResearchCutaneousDefectDermalDermisDevelopmentDiseaseDoseElementsEnvironmentEpithelial CellsFrequenciesFunctional disorderGoalsGrowthHumanImmune TargetingImmune responseImmune systemImmunosuppressionImmunosuppressive AgentsImmunotherapyIncidenceInflammationInflammatoryInnovative TherapyInterruptionInterventionLeadLesionLymphocyteMeasuresMicrobeMissionMupirocinMyelogenousNatureOralPatientsPeptide HydrolasesPeptidesPhenotypePlayPopulationRecurrenceResearchSeveritiesShapesSkinStaphylococcus aureusStaphylococcus hominisSurfaceTestingTopical AntibioticTopical applicationToxinTriamcinoloneWorkantimicrobialbasebeneficial microorganismcohortdysbiosisfightingimprovedinnovationinsightkeratinocytemast cellmembermicrobialmicrobiomemicrobiome therapeuticsnovel therapeutic interventionpediatric patientsprototyperesponseside effectskin barrierskin disorderskin lesionskin microbiomesuccess
项目摘要
Summary/Abstract
Atopic dermatitis (AD) is a common inflammatory skin disease. Recent observations strongly suggest
that the abnormal microbiome present on the skin of subjects with AD is a major factor that influences the
severity and chronic nature of this disorder. In particular, Staphylococcus aureus promotes epidermal barrier
dysfunction and exacerbates the local and systemic immune response. In healthy subjects, beneficial
members of the skin microbiome act to limit the growth of Staphylococcus aureus but these beneficial bacterial
strains are missing on adults with AD. This project seeks to understand why adults with AD lack beneficial
bacterial strains by study of the survival of a prototype strain of Staphylococcus hominis on AD skin.
Interventions to improve its survival will be tested, and application in the pediatric AD population will be
evaluated. Overall, successful completion of the proposed aims of this ADRN Clinical Research Center will
advance understanding of AD and provide essential information to permit development of an innovative new
therapeutic approach based on targeted microbiome therapy.
摘要/摘要
特应性皮炎(AD)是一种常见的炎症性皮肤病。最近的观察强烈表明
存在于AD受试者皮肤上的异常微生物组是影响AD治疗的主要因素。
这种疾病的严重性和慢性性质。特别是,金黄色葡萄球菌促进表皮屏障
功能障碍并加剧局部和全身免疫应答。在健康受试者中,
皮肤微生物组的成员起到限制金黄色葡萄球菌生长的作用,但这些有益的细菌
在AD患者身上没有发现菌株。该项目旨在了解为什么成年AD患者缺乏有益的
通过研究人葡萄球菌的原型菌株在AD皮肤上的存活来确定细菌菌株。
将测试改善其生存率的干预措施,并将在儿童AD人群中应用
评估。总体而言,成功完成ADRN临床研究中心的拟定目标将
促进对AD的理解,并提供必要的信息,以允许开发创新的新
基于靶向微生物组疗法的治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard L Gallo其他文献
MEMBRANE POTENTIAL RESPONSES OF TYPE II CELLS DURING SURFACTANT SECRETION
表面活性物质分泌过程中Ⅱ型细胞的膜电位反应
- DOI:
10.1203/00006450-198404001-01787 - 发表时间:
1984-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Jacob N Finkelstein;Richard L Gallo;Robert H Notter;Donald L Shapiro - 通讯作者:
Donald L Shapiro
Microencapsulated Benzoyl Peroxide for Rosacea in Context: A Review of the Current Treatment Landscape
微囊过氧化苯甲酰治疗红斑痤疮的背景:当前治疗前景的回顾
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:11.5
- 作者:
Seemal R. Desai;Hilary E Baldwin;James Q Del Rosso;Richard L Gallo;Neal Bhatia;Julie C. Harper;J. York;L. Gold - 通讯作者:
L. Gold
Richard L Gallo的其他文献
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{{ truncateString('Richard L Gallo', 18)}}的其他基金
Acne: a disease of lipid metabolism, microbiome and the immune response
痤疮:一种脂质代谢、微生物组和免疫反应疾病
- 批准号:
10404436 - 财政年份:2022
- 资助金额:
$ 47.3万 - 项目类别:
Quorum sensing, diversity and skin inflammation
群体感应、多样性和皮肤炎症
- 批准号:
10411990 - 财政年份:2020
- 资助金额:
$ 47.3万 - 项目类别:
Quorum sensing, diversity and skin inflammation
群体感应、多样性和皮肤炎症
- 批准号:
10189516 - 财政年份:2020
- 资助金额:
$ 47.3万 - 项目类别:
Quorum sensing, diversity and skin inflammation
群体感应、多样性和皮肤炎症
- 批准号:
10421700 - 财政年份:2020
- 资助金额:
$ 47.3万 - 项目类别:
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