Mechanisms of Trauma-Induced Coagulopathy

计划摘要/摘要 我们创伤研究中心培训计划的基本目标是激励下一个 一代外科实习生追求包括基础科学和转化的职业 调查。在外科科学家变得越来越稀少的时候，这项培训拨款对于维持外科科学家的地位至关重要 临床活跃的外科医生参与基础研究。虽然我们中心的主要关注点是创伤引起的 凝血病和炎症，我们相信我们的计划中机会的多样性，以及一般 凝血/炎症过程对其他学科的适用性，确保与任何外科手术的相关性 实习生。我们的次要目标是招募有能力的外科医生进入学术创伤外科领域，其中 缺乏研究已成为国家危机。创伤仍然是美国的首要死因 年龄小于 46 岁的个体，出血是这些可预防死亡的主要原因。 因此，在这一领域进行基础和转化研究的必要性至关重要，并且仍然是我们的灵感所在。 我们计划的设计是为期两年的全职承诺进行基础调查 主要在科罗拉多大学安舒茨医学院内完善的外科研究实验室进行 校园，补充了我们地区一级 Ernest 的前瞻性临床研究生成的患者数据 丹佛健康中心 E Moore 休克创伤中心。实验工作将集中于扰乱机制 凝血-炎症稳态，包括蛋白质组学、代谢组学和 基因组学。 这项基础研究的主要资助将是 1RM1GM13968“复苏策略” 实现血栓炎症稳态”由 NIGMS 资助，UM1HL120877 TACTIC 由 NHLBI 资助， DOD-W81XWH – 12-2-0028“创伤性急性凝血病”由国防部资助。 临床研究将主要由 DOD W81XWH–12-2-0028 W81XWH-16-D-0024“链接 创伤调查和紧急服务临床研究网络”（LITES）以及一些 机构和行业支持的试验。外科研究员将开始参与 连续两年普外科住院医师实习第二年或第三年（PGY 2 或 3）后的课程。 我们鼓励攻读高级学位，例如硕士、公共卫生硕士和博士，在研究生院接受培训 医学教育。 与过去一样，我们每年为四个职位请求资金，按顺序排列，以便第一和第二 年度研究员被分配到我们的核心实验室。

Program Summary/Abstract The fundamental objective of our Trauma Research Center Training Program is to inspire the next generation of surgical trainees to pursue a career that includes basic science and translational investigation. At a time when surgical scientists are becoming rare, this training grant is critical to maintain the participation of clinically active surgeons in basic research. While our Center’s primary focus is Trauma-Induced Coagulopathy and Inflammation, we believe the diversity of opportunities within our Program, and general applicability of the coagulation/inflammation process to other disciplines, ensures relevance to any surgical trainee. Our secondary objective is to recruit capable surgeons to the field of academic trauma surgery in which lack of research has become a national crisis. Trauma remains the leading cause of death in the US for individuals younger than 46 years of age with bleeding the primary cause of these preventable deaths. Hence the need for basic and translational investigation in this area is essential and remains our inspiration. The design of our Program is a two-year full-time commitment to basic investigation conducted primarily in well-established surgical research laboratories within the University of Colorado Anschutz Medical Campus, supplemented by patient data generated from prospective clinical studies at our regional Level I Ernest E Moore Shock Trauma Center at Denver Health. Experimental work will focus on the mechanisms disrupting coagulation-inflammatory homeostasis, and includes investigation with proteomics, metabolomics, and genomics. The major funding for this basic research will be the 1RM1GM13968 “Resuscitation Strategies for Achieving Thrombo-inflammation Homeostasis” funded by NIGMS, UM1HL120877 TACTIC funded by NHLBI, and DOD-W81XWH – 12-2-0028 “Acute Coagulopathy of Trauma” funded by the Department of Defense. Clinical studies will be funded dominantly by the DOD W81XWH–12-2-0028 W81XWH-16-D-0024 “Linking Investigation in Trauma and Emergency Service Clinical Research Network” (LITES) as well as a number of institution and industry supported trials. The surgical research fellows will commence participation in the Program after the second or third year of general surgery residency (PGY 2 or 3) for two consecutive years. We encourage pursuit of advanced degrees, e.g. MS, MPH, and PhD, with training in the School of Graduate Medical Education. As in the past, we are requesting funding for four positions annually, sequenced so that first and second year fellows are assigned to our core laboratories.