Mechanisms of Trauma-Induced Coagulopathy

项目概要/摘要 我们的创伤研究中心培训计划的基本目标是激励下一个 一代外科实习生追求的职业生涯，包括基础科学和翻译 调查在外科科学家越来越少的时候，这项培训补助金对于维持 临床活跃的外科医生参与基础研究。虽然我们中心的主要重点是创伤诱导 凝血病和炎症，我们相信我们的计划中的机会的多样性， 凝血/炎症过程对其他学科的适用性，确保与任何外科手术相关 实习生。我们的次要目标是招募有能力的外科医生到学术创伤外科领域， 缺乏研究已成为一个国家的危机。创伤仍然是美国人死亡的主要原因， 46岁以下的人出血是这些可预防死亡的主要原因。 因此，需要在这一领域的基础和翻译的调查是必不可少的，仍然是我们的灵感。 我们的设计方案是一个为期两年的全职承诺进行基本调查 主要是在科罗拉多大学安舒茨医学院内成熟的外科研究实验室 校园，辅以我们的区域I级Ernest前瞻性临床研究产生的患者数据 丹佛健康中心的E摩尔休克创伤中心。实验工作将集中在破坏的机制 凝血-炎症稳态，包括蛋白质组学，代谢组学和 基因组学 这项基础研究的主要资金将是1 RM 1GM 13968“复苏策略， 实现血栓炎症稳态”由NIGMS资助，UM 1HL 120877 TACTIC由NHLBI资助， 和由国防部资助的DOD-W81 XWH- 12-2-0028“创伤急性凝血病”。 临床研究将主要由DOD W81 XWH-12-2-0028和W81 XWH-16-D-0024“链接”资助 创伤和急救服务临床研究网络的调查”（LITES）以及一些 机构和行业支持的试验。外科研究员将开始参加 计划后的第二年或第三年的普通外科住院医师（PGY 2或3）连续两年。 我们鼓励追求高级学位，例如MS，MPH和博士，并在研究生院进行培训。 医学教育。 与过去一样，我们每年要求为四个职位提供资金，并按顺序排列，以便第一和第二个职位 年度研究员被分配到我们的核心实验室。

Program Summary/Abstract The fundamental objective of our Trauma Research Center Training Program is to inspire the next generation of surgical trainees to pursue a career that includes basic science and translational investigation. At a time when surgical scientists are becoming rare, this training grant is critical to maintain the participation of clinically active surgeons in basic research. While our Center’s primary focus is Trauma-Induced Coagulopathy and Inflammation, we believe the diversity of opportunities within our Program, and general applicability of the coagulation/inflammation process to other disciplines, ensures relevance to any surgical trainee. Our secondary objective is to recruit capable surgeons to the field of academic trauma surgery in which lack of research has become a national crisis. Trauma remains the leading cause of death in the US for individuals younger than 46 years of age with bleeding the primary cause of these preventable deaths. Hence the need for basic and translational investigation in this area is essential and remains our inspiration. The design of our Program is a two-year full-time commitment to basic investigation conducted primarily in well-established surgical research laboratories within the University of Colorado Anschutz Medical Campus, supplemented by patient data generated from prospective clinical studies at our regional Level I Ernest E Moore Shock Trauma Center at Denver Health. Experimental work will focus on the mechanisms disrupting coagulation-inflammatory homeostasis, and includes investigation with proteomics, metabolomics, and genomics. The major funding for this basic research will be the 1RM1GM13968 “Resuscitation Strategies for Achieving Thrombo-inflammation Homeostasis” funded by NIGMS, UM1HL120877 TACTIC funded by NHLBI, and DOD-W81XWH – 12-2-0028 “Acute Coagulopathy of Trauma” funded by the Department of Defense. Clinical studies will be funded dominantly by the DOD W81XWH–12-2-0028 W81XWH-16-D-0024 “Linking Investigation in Trauma and Emergency Service Clinical Research Network” (LITES) as well as a number of institution and industry supported trials. The surgical research fellows will commence participation in the Program after the second or third year of general surgery residency (PGY 2 or 3) for two consecutive years. We encourage pursuit of advanced degrees, e.g. MS, MPH, and PhD, with training in the School of Graduate Medical Education. As in the past, we are requesting funding for four positions annually, sequenced so that first and second year fellows are assigned to our core laboratories.